Article
Environmental Sciences
Zukun Wang, Xinyue Dong, Mingtong He, Junjie Liu
Summary: This study evaluated the health risks induced by chemical components and the oxidative potential of PM in the Tianjinzhan metro station, and suggested a PM control strategy based on health effect analysis. The study found that PM on the platform had notable adverse health effects, and suggested an in-depth toxicology analysis for high concentrations of Ba and Mn in PM. Additionally, a revision of the PM2.5 control limit for China metro stations was recommended to control oxidative potential on the platform.
ATMOSPHERIC ENVIRONMENT
(2024)
Article
Environmental Sciences
Yaxian Tian, Yuxuan Li, Sujing Sun, Yanrong Dong, Zhaoju Tian, Linsheng Zhan, Xiaohui Wang
Summary: With the acceleration of industrialisation and urbanisation, air pollution has become a serious global concern, particularly in terms of urban particulate matter (UPM) and its impact on human health. This study investigated the effects of UPM on erythrocyte quality, showing that UPM can have haemolytic properties and influence the oxygen-carrying function and metabolism of erythrocytes. UPM can also adhere to or be internalised by erythrocytes, altering their morphology and leading to increased phosphatidylserine exposure and subsequent clearance in vivo.
Article
Environmental Sciences
Carolina Molina, Carlos A. Manzano, Manuel A. G. Leiva, Richard A. Toro
Summary: Oxidative potential (OP) is a parameter that can indicate the ability of particulate matter (PM) to generate reactive oxygen species (ROS). This study evaluated the OP of PM10, PM2.5, and PM1.0 samples in two cities of Chile. The results showed differences in OP between cities, PM size fractions, and seasons, and a strong correlation between OP and certain metals and meteorological variables. Based on these findings, it is suggested that OP be used as a complementary measure to PM mass concentration in air quality management.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
B. Konczak, M. Cempa, L. Pierzchala, M. Deska
Summary: The rapid development of urbanized areas and transportation infrastructure has led to deteriorating air quality, with dust pollution posing a threat to human health. The analysis of elemental composition of PM stored on leaf surfaces, including high concentrations of heavy metals, highlights the importance of trees in phytoremediation of air pollution.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Wenye Li, Wenqiang Zhang, Baoqing Shan, Baoping Sun, Xiaoping Guo, Zhenhan Li
Summary: This study examines the spatial distribution, potential ecological risks, and sources of heavy metals associated with suspended particulate matter (SPM) in the Beiyun River in northern China. The results reveal a high potential ecological risk in the study area, with cadmium representing the highest pollution risk among the measured heavy metals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ta-Chih Hsiao, Li-Ti Chou, Shih-Yu Pan, Li-Hao Young, Kai-Hsien Chi, Albert Y. Chen
Summary: The study found significant diurnal variations in oxidative potential (OP), with higher OPm during the day and higher OPv at night, showing strong correlations with PM1.0 and BC. Traffic emissions were identified as the main contributor to OP throughout the day, with organic matter and metals associated with non-exhaust traffic emissions playing a substantial role. Diurnal changes in PAH concentrations suggest that photochemical reactions may enhance OP, emphasizing the significance of atmospheric aging on PM toxicity.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Nirmal Kumar Gali, Svetlana Stevanovic, Reece Alexander Brown, Zoran Ristovski, Zhi Ning
Summary: This study investigated the role of atmospheric SVOCs in gas-particle partitioning through thermal desorption and online measurement of reactive oxygen species. The results showed a decrease in mass concentrations of PM2.5 and p-PAHs at high temperatures, while BC concentrations also decreased. Measurements of ROS followed a similar trend to PM concentrations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Sumit K. Dey, Kavya Sugur, Venkataramana G. Venkatareddy, Pradhi Rajeev, Tarun Gupta, Rajesh K. Thimmulappa
Summary: This study demonstrates that exposure to PM induces lipid peroxidation, and proposes a novel approach to assess the oxidative potential of PM and predict biological toxicity. Oxidized-phospholipids are identified as significant biomarkers for PM lipid peroxidation index (PMOP), which can be used to evaluate the potential harm of PM exposure.
Article
Environmental Sciences
Pietro Morozzi, Luca Bolelli, Erika Brattich, Elida Nora Ferri, Stefano Girotti, Stefano Sangiorgi, J. A. G. Orza, Francisco Pinero-Garcia, Laura Tositti
Summary: A new chemiluminescent method based on luminol light emission induced by free radicals in airborne particulate matter is proposed in this study for rapid characterization of samples from different sources. A cell-free, luminescent assay combined with chemometric analysis was used to quickly sort particulate samples with different light emission profiles. The effectiveness of the method was demonstrated through analysis of certified reference materials and particulate matter samples, highlighting the distinct behavior among different samples and supporting the suitability of the approach.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Despina Paraskevopoulou, Aikaterini Bougiatioti, Pavlos Zarmpas, Maria Tsagkaraki, Athanasios Nenes, Nikolaos Mihalopoulos
Summary: This study evaluates the impact of air pollution emissions during the COVID-19 lockdown period on aerosol oxidative potential (OP) and finds that the reduction in traffic is not sufficient to cause significant changes in aerosol OP, suggesting that other sources are the main contributors to OP in Athens, Greece.
Article
Engineering, Environmental
Ziyin Tang, Jeremy A. Sarnat, Rodney J. Weber, Armistead G. Russell, Xiaoyue Zhang, Zhenjiang Li, Tianwei Yu, Dean P. Jones, Donghai Liang
Summary: The study found that particulate oxidative potential may be a key parameter for particulate matter toxicity. By examining the biological changes and underlying molecular mechanisms associated with particulate oxidative potential, the study identified leukotriene metabolism and galactose metabolism in plasma, and vitamin E metabolism and leukotriene metabolism in saliva as top pathways associated with FPMOP. The study also observed different patterns of perturbed pathways for water-soluble and -insoluble FPMOP, and identified five metabolites directly associated with FPMOP. These findings suggest that FPMOP may be a more sensitive and health-relevant measure for understanding the causes related to PM2.5 exposures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Wei Hu, Yanhua Wang, Ting Wang, Qianpeng Ji, Qiang Jia, Tao Meng, Sai Ma, Zhihu Zhang, Yanbo Li, Rui Chen, Yufei Dai, Yang Luan, Zhiwei Sun, Shuguang Leng, Huawei Duan, Yuxin Zheng
Summary: The study found that PM2.5 and total PAHs concentrations were significantly correlated with increased levels of urinary 8OHdG, 8-iso-PGF2α, and MDA. Essential metals showed exposure-response increase in 8-OHdG levels. Certain metals were significantly correlated with urinary 8-iso-PGF2α and MDA. Each one-unit increase in urinary total OH-PAHs resulted in increases in 8-OHdG, 8-iso-PGF2α, and MDA. Additionally, all 12 urinary metals showed significant and positive correlations with oxidative stress biomarkers in all subjects.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Wei Wang, Guodong Cao, Jing Zhang, Zhifeng Chen, Chuan Dong, Jianmin Chen, Zongwei Cai
Summary: This study reveals significant oxidative potential induced by emerging PPD-quinones in urban PM2.5, contributing to our understanding of the toxicity of both PM2.5 and PPD-quinones, and aiding in the assessment of their environmental risk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Ritwika Roy, Rohi Jan, Renuka Bhor, Kalpana Pai, P. Gursumeeran Satsangi
Summary: The present study emphasizes the importance of examining the toxicological profile of size-segregated particulate matter (PM) bound metals and their impact on health risks. The results indicate the association of metal elements in PM with inflammatory responses and cell death, as well as the contribution of different PM sizes to respiratory deposition in different regions.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Environmental Sciences
Keegan Lopez, Alexandra Camacho, Quiteria Jacquez, Mary Kay Amistadi, Sebastian Medina, Katherine Zychowski
Summary: This study assessed the mechanisms and systemic health impacts of inhaled particulate matter (PM) in a rodent model. The results showed that CCL-2 was upregulated in lung tissue and downregulated in the brain following PM exposure. Additionally, exposure to mine-PM resulted in cerebrovascular barrier integrity deficits and increased GFAP staining, dependent on exosome inhibition. The open-field test revealed a higher stress and anxiety response in the mine-PM exposure group, which was mitigated with GW4869 intervention. Exosome lipidomics revealed substantial alterations in lipid profiles. Overall, this study suggests that lung-derived, circulating exosomes play a role in driving systemic, proinflammatory effects of inhaled PM.
Article
Nanoscience & Nanotechnology
Danail Hristozov, Lisa Pizzol, Gianpietro Basei, Alex Zabeo, Aiga Mackevica, Steffen Foss Hansen, Ilse Gosens, Flemming R. Cassee, Wim de Jong, Antti Joonas Koivisto, Nicole Neubauer, Araceli Sanchez Jimenez, Elena Semenzin, Vrishali Subramanian, Wouter Fransman, Keld Alstrup Jensen, Wendel Wohlleben, Vicki Stone, Antonio Marcomini
Editorial Material
Toxicology
Ulla Vogel, Flemming R. Cassee
PARTICLE AND FIBRE TOXICOLOGY
(2018)
Article
Environmental Sciences
Rui-Wen He, Farimah Shirmohammadi, MiriamE. Gerlofs-Nijland, Constantinos Sioutas, Flemming R. Cassee
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Nanoscience & Nanotechnology
Wim H. De Jong, Eveline De Rijk, Alessandro Bonetto, Wendel Wohlleben, Vicki Stone, Andrea Brunelli, Elena Badetti, Antonio Marcomini, Ilse Gosens, Flemming R. Cassee
Article
Toxicology
Estefania Bernal-Melendez, Marie-Christine Lacroix, Pascaline Bouillaud, Jacques Callebert, Benoit Olivier, Marie-Annick Persuy, Didier Durieux, Delphine Rousseau-Ralliard, Josiane Aioun, Flemming Cassee, Anne Couturier-Tarrade, Sarah Valentino, Pascale Chavatte-Palmer, Henri Schroeder, Christine Baly
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Review
Toxicology
Michael Riediker, Daniele Zink, Wolfgang Kreyling, Gunter Oberdorster, Alison Elder, Uschi Graham, Iseult Lynch, Albert Duschl, Gaku Ichihara, Sahoko Ichihara, Takahiro Kobayashi, Naomi Hisanaga, Masakazu Umezawa, Tsun-Jen Cheng, Richard Handy, Mary Gulumian, Sally Tinkle, Flemming Cassee
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Review
Medicine, Legal
Peter M. J. Bos, Ilse Gosens, Liesbeth Geraets, Christiaan Delmaar, Flemming R. Cassee
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Allergy
Dingyu Liu, James G. Wagner, Jack R. Harkema, Miriam E. Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Rob J. Vandebriel, Flemming R. Cassee
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Article
Toxicology
Dingyu Liu, James G. Wagner, Rob Mariman, Jack R. Harkema, Miriam E. Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Flemming R. Cassee, Rob J. Vandebriel
INHALATION TOXICOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Maria Joao Bessa, Fatima Brandao, Paul Fokkens, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, Joao Paulo Teixeira, Sonia Fraga
Summary: The study highlighted the potential hazard associated with exposure to incidental nanoparticles in industrial settings. Results indicated that process-generated nanoparticles and fine particles possess higher toxicity potential compared to engineered nanoparticles in terms of mass per area unit. However, the presence of a mucociliary apparatus as a defense mechanism significantly attenuated the observed toxic effects.
Article
Chemistry, Analytical
Ariana Lammers, Anne H. Neerincx, Susanne J. H. Vijverberg, Cristina Longo, Nicole A. H. Janssen, A. John F. Boere, Paul Brinkman, Flemming R. Cassee, Anke H. Maitland van der Zee
Summary: This study explored the effects of short-term exposure to air pollution on the exhaled breath profiles of healthy adults, finding that high levels of air pollution may influence breath composition, although the impact may be minimal for regular daily exposures.
Article
Chemistry, Multidisciplinary
Maria Joao Bessa, Fatima Brandao, Paul H. B. Fokkens, Daan L. A. C. Leseman, A. John F. Boere, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, Joao Paulo Teixeira, Sonia Fraga
Summary: Diverse industries have incorporated engineered nanoparticles (ENP) into their production processes, increasing the risk of worker inhalation exposure. In vitro models, particularly using air-liquid interface (ALI) cell cultures, are valuable for studying ENP toxicity. When comparing submerged and ALI conditions for ENP exposure, it was found that ALI cultures were more sensitive to the cytotoxic effects of ENP on human alveolar epithelial-like cells.
Article
Toxicology
Yvonne C. M. Staal, Yixuan Li, Lora-Sophie Gerber, Paul Fokkens, Hans Cremers, Flemming R. Cassee, Reinskje Talhout, Remco H. S. Westerink, Harm J. Heusinkveld
Summary: The direct effects of inhaled harmful constituents primarily affect the airways, but these compounds can also be rapidly absorbed and cause systemic effects. This study combines in vitro systems to evaluate the neurological effects of inhaled compounds. The results demonstrate that exposure to e-cigarette vapor induces the production of cytokines in lung cells and the translocation of compounds across the cell culture. Furthermore, exposure-related changes in neuronal electrical activity were observed when the cell culture medium was transferred to neuronal cells. This approach can realistically assess the neurotoxic effects of inhaled compounds and contribute to future risk assessment strategies based on mechanisms.
INHALATION TOXICOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Nienke Ruijter, Lya G. Soeteman-Hernandez, Marie Carriere, Matthew Boyles, Polly McLean, Julia Catalan, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sanchez Jimenez, Ana Candalija, Isabel Rodriguez-Llopis, Socorro Vazquez-Campos, Flemming R. Cassee, Hedwig Braakhuis
Summary: The Safe-by-Design (SbD) concept aims to enhance the development of safer materials/products by reducing hazards and exposures through timely interventions. This review evaluates commonly used in vitro assays for their suitability in SbD hazard testing of nanomaterials (NMs). It also discusses the effects of various factors on predictivity and the compatibility of assays with advanced materials and NMs released during the lifecycle.
Article
Toxicology
Ali Reza Nosratabadi, Mats Gustafsson, Karin Loven, Stefan A. Ljunggren, Ulf Olofsson, Saeed Abbasi, Goran Blomqvist, Helen Karlsson, Anders G. Ljungman, Flemming R. Cassee, Miriam E. Gerlofs-Nijland, Anders Gudmundsson
Summary: This study investigated the effects of road and brake wear particles on pulmonary function and biomarkers in isolated perfused rat lungs. The results showed that particles from road quartzite and brake materials had significant effects on tidal volume and cytokine levels. The choice of rock material in road pavements has the potential to affect the toxicity of road wear particles.
INHALATION TOXICOLOGY
(2023)
