Can the comet assay be used reliably to detect nanoparticle-induced genotoxicity?

High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology

(2014) Christa Watson et al.   ACS Nano

In vitrotoxicological assessment of iron oxide, aluminium oxide and copper nanoparticles in prokaryotic and eukaryotic cell types

(2014) Rakhshinda Sadiq et al.   DRUG AND CHEMICAL TOXICOLOGY

Cellular interactions and biological responses to titanium dioxide nanoparticles in HepG2 and BEAS-2B cells: Role of cell culture media

(2014) Raju Y. Prasad et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles

(2014) Sebastiano Di Bucchianico et al.   International Journal of Nanomedicine

Effect of Treatment Media on the Agglomeration of Titanium Dioxide Nanoparticles: Impact on Genotoxicity, Cellular Interaction, and Cell Cycle

(2013) Raju Y. Prasad et al.   ACS Nano

Genotoxic and carcinogenic potential of engineered nanoparticles: an update

(2013) Ashutosh Kumar et al.   ARCHIVES OF TOXICOLOGY

Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification

(2013) Stefan Pfuhler et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential

(2013) Eşref Demir et al.   JOURNAL OF HAZARDOUS MATERIALS

High-throughput comet assay using 96 minigels

(2013) Kristine B. Gutzkow et al.   MUTAGENESIS

Multiple cytotoxic and genotoxic effects induced in vitro by differently shaped copper oxide nanomaterials

(2013) Sebastiano Di Bucchianico et al.   MUTAGENESIS

An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells

(2013) C. Ersson et al.   MUTAGENESIS

Iron oxide nanoparticle toxicity testing using high-throughput analysis and high-content imaging

(2013) Georgina Harris et al.   Nanotoxicology

Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classicin vitrotests

(2013) Rina Guadagnini et al.   Nanotoxicology

Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

(2013) Zuzana Magdolenova et al.   Nanotoxicology

Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison Between Nanoparticles and their Corresponding Metal Ions

(2013) Pontus Cronholm et al.   Small

Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity

(2013) Sijing Xiong et al.   TOXICOLOGY

Cell membrane damage and protein interaction induced by copper containing nanoparticles—Importance of the metal release process

(2013) Hanna L. Karlsson et al.   TOXICOLOGY

Dose-dependent genotoxicity of copper oxide nanoparticles stimulated by reactive oxygen species in human lung epithelial cells

(2013) Mohammad Javed Akhtar et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Oxidative DNA damage corresponds to the long term survival of human cells treated with silver nanoparticles

(2013) Marcin Kruszewski et al.   TOXICOLOGY LETTERS

Interference of engineered nanoparticles with in vitro toxicity assays

(2012) Alexandra Kroll et al.   ARCHIVES OF TOXICOLOGY

Distinctive Toxicity of TiO2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells

(2012) Kirsten Gerloff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity

(2012) Zuzana Magdolenova et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Cyto-/Genotoxic Effect of CdSe/ZnS Quantum Dots in Human Lung Adenocarcinoma Cells for Potential Photodynamic UV Therapy Applications

(2012) Young Joo Choi et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Can Standard Genotoxicity Tests be Applied to Nanoparticles?

(2012) Zuzana Magdolenova et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Inter-laboratory variation in DNA damage using a standard comet assay protocol

(2012) Lykke Forchhammer et al.   MUTAGENESIS

DNA damage induced by micro- and nanoparticles--interaction with FPG influences the detection of DNA oxidation in the comet assay

(2012) J. Kain et al.   MUTAGENESIS

Genotoxicity testing of PLGA–PEO nanoparticles in TK6 cells by the comet assay and the cytokinesis-block micronucleus assay

(2012) Alena Kazimirova et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots

(2012) Mélanie Aye et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Experimental evidence of false-positive Comet test results due to TiO2particle – assay interactions

(2012) Katarina Rajapakse et al.   Nanotoxicology

Genotoxic effects of copper oxide nanoparticles in Neuro 2A cell cultures

(2012) François Perreault et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro

(2012) Hanna K. Lindberg et al.   TOXICOLOGY

Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells

(2012) Penny Nymark et al.   TOXICOLOGY

Epigenetic effects of nano-sized materials

(2012) Andrea Stoccoro et al.   TOXICOLOGY

A comparative performance test of standard, medium- and high-throughput comet assays

(2012) Amaya Azqueta et al.   TOXICOLOGY IN VITRO

Molecular Responses of Human Lung Epithelial Cells to the Toxicity of Copper Oxide Nanoparticles Inferred from Whole Genome Expression Analysis

(2011) Nobutaka Hanagata et al.   ACS Nano

Cytotoxicity and Genotoxicity of Size-Fractionated Iron Oxide (Magnetite) in A549 Human Lung Epithelial Cells: Role of ROS, JNK, and NF-κB

(2011) Mathias Könczöl et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Study of serum interaction with a cationic nanoparticle: Implications for in vitro endocytosis, cytotoxicity and genotoxicity

(2011) Maysaloun Merhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The influence of scoring method on variability in results obtained with the comet assay

(2011) A. Azqueta et al.   MUTAGENESIS

Effects of single and multi walled carbon nanotubes on macrophages: Cyto and genotoxicity and electron microscopy

(2011) Maria Laura Di Giorgio et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells

(2011) Ha Ryong Kim et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells

(2011) Mary-Line Jugan et al.   Nanotoxicology

TiO2nanoparticles induce oxidative DNA damage and apoptosis in human liver cells

(2011) Ritesh K Shukla et al.   Nanotoxicology

Validation of an LDH assay for assessing nanoparticle toxicity

(2011) Xianglu Han et al.   TOXICOLOGY

The comet assay in nanotoxicology research

(2010) Hanna L. Karlsson   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells

(2010) Maqusood Ahamed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative studies on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer in Jurkat T-cells

(2010) Young Joo Choi et al.   DRUG AND CHEMICAL TOXICOLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells

(2010) Ilham F Osman et al.   Nanomedicine

Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models

(2010) Laetitia Gonzalez et al.   Nanotoxicology

ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells

(2010) Ritesh K. Shukla et al.   TOXICOLOGY IN VITRO

Twelve-gel slide format optimised for comet assay and fluorescent in situ hybridisation

(2010) Sergey Shaposhnikov et al.   TOXICOLOGY LETTERS

Development ofin vitrosystems for nanotoxicology: methodological considerations

(2009) Vicki Stone et al.   CRITICAL REVIEWS IN TOXICOLOGY

Genotoxic effects of nanosized and fine TiO2

(2009) GCM Falck et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Comparison of organic and inorganic germanium compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer

(2009) Ming-Hsing Lin et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Confounding experimental considerations in nanogenotoxicology

(2009) S.H. Doak et al.   MUTAGENESIS

Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts

(2009) J. Ponti et al.   MUTAGENESIS

DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

(2009) PV Asharani et al.   Nanomedicine

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

(2008) P. V. AshaRani et al.   ACS Nano

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

(2008) Hanna L. Karlsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

(2008) Su Jin Kang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro

(2008) R. Colognato et al.   MUTAGENESIS

Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro

(2008) Hanna K. Lindberg et al.   TOXICOLOGY LETTERS