Article
Biochemistry & Molecular Biology
Robin A. F. Verwilligen, Lindsay Mulder, Pedro M. Araujo, Miguel Carneiro, Jeroen Bussmann, Menno Hoekstra, Miranda Van Eck
Summary: Scavenger receptor class B1 (SCARB1) is a multi-ligand scavenger receptor that is primarily expressed in liver and steroidogenic organs. This study created two stable scarb1 knockout zebrafish lines and found that SCARB1 deficiency in zebrafish leads to disruption of carotenoid-based pigmentation, reduced fertility, and decreased larvae survival rate. It also affects the uptake of HDL in the liver, but this is attributed to reduced perfusion.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Immunology
Dan Hao, Ling Guo, Qian Wang, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li
Summary: This study utilized a new relative adrenal insufficiency (RAI) pediatric mouse model to evaluate the pathogenesis of RAI and the effect of glucocorticoid (GC) therapy. The results showed that RAI mice had a significantly higher mortality rate in sepsis and were effectively rescued by GC therapy. RNA sequencing analysis revealed persistent inflammatory responses in RAI mice caused by transcriptional dysregulation of AP-1 and NF-κB and cytokine-induced secondary inflammatory response. Therefore, this research supports a precision medicine approach to guide GC therapy for pediatric patients based on RAI status.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi
Summary: CD36 plays an important role in podocyte injury in lupus nephritis by activating NLRP3 inflammasome and inhibiting autophagy, and enhancing autophagy can decrease NLRP3 inflammasome and alleviate podocyte injury.
CELL DEATH & DISEASE
(2022)
Review
Peripheral Vascular Disease
Liming Yu, Yao Dai, Chieko Mineo
Summary: SR-BI plays a key role in reverse cholesterol transport as the high-affinity receptor for HDL in the liver, but recent studies have also revealed its novel functions in regulating transcellular transport of LDL and HDL in endothelial cells, which may have both anti-atherogenic and pro-atherogenic effects.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Ophthalmology
Haixiang Huang, Zhuang Li, Jun Huang, Yanyan Xie, Zhiqiang Xiao, Yunwei Hu, Guanyu Chen, Minzhen Wang, Zuoyi Li, Qian Chen, Wenjie Zhu, Wenru Su, Yan Luo, Xiaoqing Chen, Dan Liang
Summary: In this study, researchers investigated the role of apolipoprotein A1 (APOA1) in experimental autoimmune uveitis (EAU), a representative animal model of human uveitis. They found that APOA1 administration ameliorated EAU by regulating the expansion and infiltration of pathogenic T cells, as well as the production of inflammatory cytokines. The results suggest that APOA1 could be a therapeutic alternative for autoimmune uveitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Virology
Victoria L. Arandhara, Charles Patrick McClure, Alexander W. Tarr, Sally Chappell, Kevin Morgan, Thomas F. Baumert, William L. Irving, Jonathan K. Ball
Summary: Analysis of host genetic polymorphisms can provide valuable insights into the pathogenesis and treatment response of viral diseases. A study found that a specific genetic polymorphism (rs5888) within the SR-BI gene locus is associated with advanced liver fibrosis in chronic HCV infection. The presence of the variant allele T of rs5888 is linked to reduced expression of SR-BI and increased risk for severe disease in HCV-infected individuals.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Chia-Hua Wu, Ling Guo, Dan Hao, Qian Wang, Xiang Ye, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li
Summary: This study used SF1CreSR-BIfl/fl mice as a model of relative adrenal insufficiency (RAI) to reveal the risk of death associated with RAI in sepsis and demonstrate that RAI is an endotype of sepsis characterized by persistent hyperinflammatory response. Furthermore, they found that GC treatment is beneficial for mice with RAI but harmful for mice without RAI. Therefore, this study supports a precision medicine approach in sepsis therapy, selectively applying GC treatment for patients with RAI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Tyler R. McCaw, Nidhi Goel, Dewey J. Brooke, Ashwini A. Katre, Angelina I. Londono, Haller J. Smith, Troy D. Randall, Rebecca C. Arend
Summary: The study found that treatment with the class 1 HDAC inhibitor entinostat can enhance the expression of pathways and genes associated with CD8 T cell cytotoxic function, while downregulating myeloid derived suppressor cell chemoattractants. The suppressive capacity of regulatory T cells within tumors and associated ascites was significantly reduced, reversing the CD8-Treg ratio.
Review
Medicine, General & Internal
Greet Van den Berghe, Arno Teblick, Lies Langouche, Jan Gunst
Summary: The traditional model of increased systemic glucocorticoid availability in response to sepsis and hyperinflammation-induced critical illness has been challenged in recent research, revealing a more complex and time-dependent set of responses. Cortisol production driven by ACTH is only temporarily increased, followed by orchestrated peripheral adaptations to maintain increased cortisol availability for target tissues without the need for continued production, along with changes at target tissues to guide cortisol action according to tissue-specific needs.
Review
Biochemistry & Molecular Biology
Ioannis Ilias, Alice G. Vassiliou, Chrysi Keskinidou, Charikleia S. Vrettou, Stylianos Orfanos, Anastasia Kotanidou, Ioanna Dimopoulou
Summary: Sepsis leads to dysregulated cortisol secretion, resulting in abnormal cortisol levels in the blood. Initial stages of the condition show elevated cortisol levels due to increased secretion from the adrenal glands, but as the disease progresses, cortisol levels may decline due to impaired adrenal function. The dysregulation of cortisol secretion in sepsis impairs the body's ability to mount an appropriate inflammatory response, contributing to the pathophysiology of the disease.
Article
Pharmacology & Pharmacy
Mitali Pandey, Grace Cuddihy, Jacob A. Gordon, Michael E. Cox, Kishor M. Wasan
Summary: Studies have linked elevated SR-B1 expression to the development and progression of castration-resistant prostate cancer (CRPC), with potential implications for patient survival. Modulation of cholesterol synthesis or uptake through targeting SR-B1 may impede prostate cancer proliferation, providing a potential therapeutic target for treatment.
Review
Biochemistry & Molecular Biology
Roberto Buonaiuto, Giuseppe Neola, Sabrina Chiara Cecere, Aldo Caltavituro, Amedeo Cefaliello, Erica Pietroluongo, Pietro De Placido, Mario Giuliano, Grazia Arpino, Carmine De Angelis
Summary: Ovarian cancer is the leading cause of death from gynecological malignancies worldwide. The glucocorticoid receptor (GR) plays a critical role in ovarian cancer and may impact treatment response. Low levels of glucocorticoids can suppress ovarian cancer growth and metastasis, while high GR expression is associated with poor prognosis and outcomes. GR activation also impairs the effectiveness of chemotherapy. This review summarizes the function and role of GR in ovarian cancer and explores its potential as a prognostic and predictive biomarker. It also discusses the interplay between GR and BRCA expression and reviews new therapeutic strategies to enhance chemotherapy sensitivity.
Article
Biochemistry & Molecular Biology
Elmira Vagapova, Maxim Kozlov, Timofey Lebedev, Karina Ivanenko, Olga Leonova, Vladimir Popenko, Pavel Spirin, Sergey Kochetkov, Vladimir Prassolov
Summary: The resistance of leukemia and neuroblastoma cells to anticancer therapy remains a challenge, but targeting HDAC with hydrazostat has shown potential in reactivating RTK expression and enhancing the efficacy of RTK inhibitors. This study reveals a promising strategy to overcome drug resistance in these diseases.
Article
Fisheries
Yinan Jiang, Yuting Wang, Yingying Zhang, Hui Yang
Summary: A novel scavenger receptor B (PcSRB) was identified in the Chinese mitten crab, which plays an important role in immune defense, particularly in the recognition and binding of pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paul-Emmanuel Vanderriele, Qing Wang, Anne-Marie Merillat, Frederique Ino, Gilles Aeschlimann, Xavier Ehret, David Ancin Del Olmo, Veronica Ponce de Leon, Ute I. Scholl, Denise V. Winter, Alex Odermatt, Edith Hummler, Sophia N. Verouti
Summary: Research on GR haploinsufficient Sprague Dawley rats revealed that they developed salt-sensitive hypertension on a high salt diet due to disruptions in sEH and fatty acid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Konstantinos Axarlis, Maria G. Daskalaki, Sofia Michailidou, Nikolais Androulaki, Antiopi Tsoureki, Evangelia Mouchtaropoulou, Ourania Kolliniati, Ioanna Lapi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Anagnostis Argiriou, Zouhir El Marsni, Christos Tsatsanis
Summary: Fish-derived supplements showed improvements in glucose intolerance, obesity, and type 2 diabetes, with supplements containing fish collagen having particularly beneficial properties. Additionally, collagen-containing supplements modulated the gut microbiome in high-fat induced obesity in mice.
Review
Immunology
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
Summary: Macrophages, as central mediators of innate immune responses, adapt to different environments and nutritional resources by utilizing energy at both normoxic and hypoxic conditions and modulating signaling pathways to shape different activation phenotypes. Systemic changes in diseases can also affect macrophage metabolism, resulting in altered activation phenotypes in adipose tissue or in the periphery.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Chemistry, Medicinal
Ioanna Lapi, Ourania Kolliniati, Tone Aspevik, Eleftherios E. Deiktakis, Konstantinos Axarlis, Maria G. Daskalaki, Eirini Dermitzaki, Maria Tzardi, Sotirios C. Kampranis, Zouhir El Marsni, Katerina C. Kousoulaki, Christos Tsatsanis, Maria Venihaki
Summary: Dietary supplementation with marine collagen-enriched supplements promoted tissue repair in a model of cutaneous wound healing, accelerating the healing process. The collagen-containing supplements increased the expression of chemokines for immune cell recruitment and elevated expression of the angiogenic factor VEGF-A, leading to enhanced collagen deposition in the damaged tissues.
Article
Chemistry, Medicinal
Maria G. Daskalaki, Konstantinos Axarlis, Tone Aspevik, Michail Orfanakis, Ourania Kolliniati, Ioanna Lapi, Maria Tzardi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Christos Tsatsanis
Summary: Inflammatory bowel disease is characterized by extensive intestinal inflammation, with therapies targeting the inflammatory cascade. Nutrition plays a crucial role in the development and suppression of inflammatory bowel disease, with fish protein hydrolysates showing potential anti-inflammatory properties in a DSS-induced colitis model, providing a novel source of health-promoting dietary supplements.
Article
Immunology
Ioanna Pantazi, Ahmed A. Al-Qahtani, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The major cause of death in SARS-CoV-2 infected patients is deregulation of the innate immune system and development of cytokine storm. SARS-CoV-2 S protein can induce pro-inflammatory cytokine production in macrophages, potentially exacerbating inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Summary: AKT-phosphorylated IWS1 promotes the alternative splicing of U2AF2, leading to regulation of mRNA nuclear export, including those encoding Type I interferons. This pathway affects sensitivity to multiple cytolytic virus infections, and may serve as a potential therapeutic target in cancer treatment.
COMMUNICATIONS BIOLOGY
(2021)
Retraction
Biology
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Eleftherios E. Deiktakis, Eleftheria Ieronymaki, Peter Zaren, Agnes Hagsund, Elin Wirestrand, Johan Malm, Christos Tsatsanis, Ilpo T. Huhtaniemi, Aleksander Giwercman, Yvonne Lundberg Giwercman
Summary: This study explores the direct effects of adding FSH on prostate size and gene expression after androgen ablation with a GnRH antagonist. The results indicate that supplementing FSH can partially restore prostate weight and increase the expression of specific genes in mice. However, in humans, FSH has no effect on PSA production.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Zacharias Christoforakis, Eirini Dermitzaki, Eleni Paflioti, Marianna Katrinaki, Michail Deiktakis, Theodoros H. Tosounidis, Konstantine Ballalis, Christos Tsatsanis, Maria Venihaki, George Kontakis
Summary: This study found that knee osteoarthritis patients with metabolic syndrome had higher concentrations of interleukin 6, and demonstrated the critical role of infrapatellar fat pad in knee joint homeostasis and progression of KOA.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Retraction
Multidisciplinary Sciences
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ahmed A. Al-Qahtani, Ioanna Pantazi, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The study found that the S protein of SARS-CoV-2 suppresses inflammatory responses in alveolar epithelial type II cells at early stages of infection by activating the PI3K/AKT pathway. Additionally, when combined with TLR2 signals, the S protein enhances PAI-1 expression, potentially affecting the local coagulation cascade.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Ioanna Pantazi, Iosif Papafragkos, Ourania Kolliniati, Ioanna Lapi, Christos Tsatsanis, Eleni Vergadi
Summary: This study found that inhibition of Akt kinase can enhance the response of non-phagocytic alveolar epithelial cells against Group B Streptococcus (GBS), promoting autophagy and GBS clearance. This finding provides a promising measure to strengthen epithelial barriers and prevent GBS invasion.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Microbiology
Elisavet Stavropoulou, Eleftheria Ieronymaki, Evangelia Dimitroulia, Theodoros C. Constantinidis, Georgia Vrioni, Christos Tsatsanis, Athanasios Tsakris
Summary: The study found that certain Greek honey samples possess anti-inflammatory and antibacterial properties, as they can suppress the production of inflammatory mediators and reduce the translocation of bacteria in tissues. These properties are comparable to or even more potent than manuka honey.
Article
Endocrinology & Metabolism
Christos Tsatsanis, Angel Elenkov, Irene Leijonhufvud, Katerina Vaporidi, Asa Tivesten, Aleksander Giwercman
Summary: Sex hormones and sex chromosomes have different impacts on cytokines involved in sex-dependent inflammatory response. The concentration of BAFF and LPS-stimulated TNF secretion depends on sex hormone levels, while basal TNF is regulated by both sex hormone-dependent and -independent factors.
ENDOCRINE CONNECTIONS
(2023)