Review
Biochemistry & Molecular Biology
Federica Del Chierico, Novella Rapini, Annalisa Deodati, Maria Cristina Matteoli, Stefano Cianfarani, Lorenza Putignani
Summary: This review summarizes the associations between gut microbiota and Type 1 Diabetes (T1D), suggesting that dysbiosis in the gut microbiota may influence the onset and progression of T1D, and microbiota-based therapies show promise in slowing down disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jianpeng Li, Siqiang Jia, Chao Yuan, Bin Yu, Zheng Zhang, Meng Zhao, Pengfei Liu, Xia Li, Bo Cui
Summary: The study focused on the protective mechanism of Jerusalem artichoke inulin against abnormal hepatic lipid metabolism and gut microbiota dysfunction in diabetic mice. It was found that consuming Jerusalem artichoke inulin significantly improved the biochemical and physiological parameters related to type 2 diabetes mellitus. Additionally, supplementation with Jerusalem artichoke inulin also improved abnormal hepatic lipid metabolism and enriched certain beneficial bacteria in the gut microbiota.
Review
Biochemistry & Molecular Biology
Lixiang Zhai, Jiayan Wu, Yan Y. Lam, Hiu Yee Kwan, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: Type 2 diabetes is a metabolic disorder characterized by insulin resistance and impaired insulin secretion leading to high blood sugar levels. Disturbances in gut microbiota play a significant role in the development of insulin resistance in T2D. Research on gut microbial metabolites and probiotics-based therapeutic strategies show promise in alleviating insulin resistance in T2D by modulating gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Debarun Patra, Dipanjan Banerjee, Palla Ramprasad, Soumyajit Roy, Durba Pal, Suman Dasgupta
Summary: Microbial imbalance is closely associated with the progression of obesity-induced metabolic disorders, and modulation of microbiota in the gut and adipose tissue could serve as one of the contemporary approaches to manage type 2 diabetes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Gastroenterology & Hepatology
Lea Henneke, Kristina Schlicht, Nadia A. Andreani, Tim Hollstein, Tobias Demetrowitsch, Carina Knappe, Katharina Hartmann, Julia Jensen-Kroll, Nathalie Rohmann, Daniela Pohlschneider, Corinna Geisler, Dominik M. Schulte, Ute Settgast, Kathrin Tuerk, Johannes Zimmermann, Christoph Kaleta, John F. Baines, Jane Shearer, Shrushti Shah, Grace Shen-Tu, Karin Schwarz, Andre Franke, Stefan Schreiber, Matthias Laudes
Summary: Recent research has found that Parasutterella plays an important role in the development of type 2 diabetes and obesity. This study analyzed a European cohort and validated the results in a Canadian cohort. The findings showed that Parasutterella was positively associated with BMI and type 2 diabetes, and its abundance was related to the intake of carbohydrates. Furthermore, the study found a reduction in L-cysteine and activation of the fatty acid biosynthesis pathway, suggesting potential mechanisms for the development of type 2 diabetes and obesity.
Article
Biochemistry & Molecular Biology
Young-Sil Lee, Daeyoung Lee, Gun-Seok Park, Seung-Hyun Ko, Juyi Park, You-Kyung Lee, Jihee Kang
Summary: The study suggests that Lactobacillus plantarum HAC01 can alleviate hyperglycemia and type 2 diabetes by regulating glucose metabolism in the liver, protecting insulin-secreting cells, and restoring gut microbiota and short-chain fatty acids.
Article
Biochemistry & Molecular Biology
Pengcheng Tu, Qiong Tang, Meng Wang, Wen Chen, Xiang Ye, Xiaodong Zheng
Summary: Dysbiosis of the gut microbiota is associated with metabolic diseases, and dietary modulation of the microbiota is a potential approach. Polyphenols extracted from fruits can protect against metabolic disorders, and this effect is related to the gut microbiota. The study found that administration of cyanidin-3-O-glucoside (C3G) reduced weight gain and fasting blood glucose levels, and significantly modulated the composition and functional pathways of the gut microbiota.
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Che-Sheng Pai, Cheng-Yuan Wang, Wei-Wen Hung, Wei-Chun Hung, Hui-Ju Tsai, Chen-Chia Chang, Shang-Jyh Hwang, Chia-Yen Dai, Wen-Yu Ho, Yi-Chun Tsai
Summary: This study revealed that in Asian T2D patients, the decreased abundance of fecal A. muciniphila exacerbated the severity of insulin resistance, especially in those with lean mass. The negative correlation between A. muciniphila and insulin resistance was found in T2D patients with high lean tissue, and this relationship was independent of obesity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Food Science & Technology
Meili Bao, Kexin Hou, Chao Xin, Deyong Zeng, Cuilin Cheng, Haitian Zhao, Zhenyu Wang, Lu Wang
Summary: Portulaca oleracea L. extracts (PE) improve diabetes-related biochemical abnormalities by modulating gut microbiota composition and branched-chain amino acids (BCAAs) metabolism, as well as protecting intestinal mucosal epithelium.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Endocrinology & Metabolism
Emma K. Rautenberg, Yassin Hamzaoui, Dawn K. Coletta
Summary: Type 2 diabetes (T2D) and obesity present major challenges in public health. Understanding the molecular mechanisms contributing to these metabolic disorders, particularly insulin resistance, is crucial. Impaired mitochondria structure and function are common features in insulin-resistant individuals with T2D or obesity, potentially due to epigenetic regulation of mitochondrial and nuclear-encoded genes. Investigating mitochondrial abnormalities is important for gaining insights into the pathogenesis of diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Danqi Wang, Jun-Xia Wang, Chunri Yan, Yize Liu, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Zheng-Yun Jin, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, Lin-Hu Quan
Summary: The study revealed that Gastrodia elata Blume extract (GEBE) can ameliorate type 2 diabetes by increasing GLUT4 expression in white adipose tissue, remodeling gut microbiota, and modifying serum bile acid concentrations.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Camila E. Orsso, Ye Peng, Edward C. Deehan, Qiming Tan, Catherine J. Field, Karen L. Madsen, Jens Walter, Carla M. Prado, Hein M. Tun, Andrea M. Haqq
Summary: This study found that children with obesity who had insulin resistance exhibited lower microbial alpha-diversity measures and an association with abundance of genes related to metabolic pathways. This indicates a potential link between gut microbiome composition, metabolic functions, and insulin resistance in pediatric obesity.
Article
Food Science & Technology
Wanxiu Cao, Fang Liu, Robert W. Li, Yaoxian Chin, Yuming Wang, Changhu Xue, Qingjuan Tang
Summary: It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. This study used a diet-induced obesity (DIO) mouse model to investigate the effects of DHA-rich fish oil (DHA-FO) on metabolic disorders and colonic microbiome. The results showed that DHA-FO reduced fat deposition, regulated lipid profiles, and alleviated insulin resistance by preventing the permeation of lipopolysaccharide and promoting peptide YY (PYY) secretion. DHA-FO also reversed microbial dysbiosis and altered gut microbial function, which were associated with PYY expression. Overall, DHA-FO enhanced insulin action on glucose metabolism by modulating gut microbiome and facilitating colonic PYY expression in DIO mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Nutrition & Dietetics
Weiwen Zhou, Kai K. Lie, Elvis Chikwati, Katerina Kousoulaki, Ingrid Lein, Oystein Saele, Ashild Krogdahl, Trond M. Kortner
Summary: A 5-week feeding trial was conducted on the cleaner fish Ballan wrasse to study the effects of different feed ingredients on gut health and digestive function. It was found that feeding the fish with prebiotics and soya saponins caused inflammation in the intestines, but did not affect fish growth.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Fisheries
Mette Sorensen, Katerina Kousoulaki, Renate Hammero, Marialena Kokkali, Dorinde Kleinegris, Francisco J. Marti-Quijal, Francisco J. Barba, Anjana Mahesh Palihawadana, Einar Skarstad Egeland, Chris Andre Johnsen, Odd Helge Romarheim, Saraswathy Bisa, Viswanath Kiron
Summary: The cell walls of microalgae have different chemical compositions and architectures. Bead milling was found to effectively disrupt the cell walls and improve the extraction of bioactive compounds from Phaeodactylum tricornutum and Tetraselmis chui. The mechanical treatment also affected the digestibility of nutrients and the content of fatty acids and pigments in Atlantic salmon.
Article
Fisheries
Johanna S. Kottmann, Gerd M. Berge, Katerina Kousoulaki, Tone-Kari Knutsdatter ostbye, Elisabeth Ytteborg, Bjarne Gjerde, Ingrid Lein
Summary: This study assessed the effect of increased dietary EPA levels and initial CF on the performance and welfare of ballan wrasse. The results showed that dietary composition influenced the FA profile of the fish, but not their growth and welfare. Low water temperatures had profound effects on the performance and welfare of ballan wrasse, and high CF appeared to help fish cope better with low temperatures.
JOURNAL OF FISH BIOLOGY
(2023)
Article
Chemistry, Medicinal
Maria G. Daskalaki, Konstantinos Axarlis, Antiopi Tsoureki, Sofia Michailidou, Christina Efraimoglou, Ioanna Lapi, Ourania Kolliniati, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Anagnostis Argiriou, Christos Tsatsanis
Summary: Obesity and type 2 diabetes can be partially controlled with protein-containing nutritional supplements derived from fish sidestreams. This study examined the effects of dietary supplementation with different protein hydrolysates from fish on obesity, diabetes, and the gut microbiome in a mouse model. The results showed that specific protein hydrolysates had beneficial effects, such as suppressing glucose intolerance and promoting changes in the gut microbiome composition.
Article
Chemistry, Medicinal
Beatriz de la Fuente, Tone Aspevik, Francisco J. Barba, Katerina Kousoulaki, Houda Berrada
Summary: The bioaccessibility of minerals in protein hydrolysates from salmon and mackerel was evaluated. The highest bioaccessibility was found for iron in salmon and mackerel head hydrolysates. The antioxidant capacity of the hydrolysates increased after in vitro digestion.
Article
Food Science & Technology
Niki Mougiou, Antiopi Tsoureki, Spyros Didos, Ioanna Bouzouka, Sofia Michailidou, Anagnostis Argiriou
Summary: The analysis of table olives microbiome using next-generation sequencing has provided valuable information about the microbial community composition of this popular fermented food. This study used 16S and 18S rRNA sequencing to evaluate the microbial communities of table olives from five Greek popular cultivars, fermented by Greek or Spanish style. The results showed that different curing and fermentation methods had an impact on the microbial composition and biochemical properties of the olives.
Article
Horticulture
Kleopatra-Eleni Nikolaou, Theocharis Chatzistathis, Serafeim Theocharis, Anagnostis Argiriou, Stefanos Koundouras
Summary: The aim of this study was to analyze the effect of excess boron on grapevines. The results showed that boron excess significantly reduced nutrient concentrations, chlorophyll content, and CO2 assimilation rate, while increasing leaf phenolic content. Rootstocks also played a role in boron toxicity, with 1103P delaying leaf boron accumulation compared to 101-14 Mgt.
Article
Agronomy
Niki Mougiou, Spyros Didos, Ioanna Bouzouka, Athina Theodorakopoulou, Michael Kornaros, Ioannis Mylonas, Anagnostis Argiriou
Summary: Research has shown that ancient grains, particularly emmer and einkorn, have higher levels of antioxidants and phytochemicals compared to modern varieties of wheat. This study compared grains from old Greek landraces of various wheat species to investigate their unique genetic profile and nutritional properties. The results revealed that emmer and einkorn had the highest levels of polyphenols, flavonoids, and mono-unsaturated fatty acids, as well as greater antioxidant activity. The study highlights the importance of sustainable agricultural practices to preserve the high nutritional value of ancient wheat varieties.
Article
Engineering, Marine
Maria Kyritsi, Antiopi Tsoureki, Konstantinos Koukaras, Nikolaos Kamidis, Grigorios Krey, Sofia Michailidou, Anagnostis Argiriou
Summary: This study assessed the seasonal dynamics of marine bacterial communities in three marine aquaculture farms in western Greece and compared them to a control site. Results showed that Proteobacteria, Bacteroidota, Cyanobacteria, and Verrucomicrobiota were the dominant phyla in the bacterial communities. Alpha diversity was significantly lower in the aquaculture farms compared to the control site, and seasonality was the major factor driving bacterial community fluctuations.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Ioanna Gkitsaki, Alexandros Papachristoforou, Sofia Michailidou, Nikolaos Karamvalis, Ioannis Iliadis, Dimitra Graikini, Christina Sakarikou, Evangelos Tsoukis, Anagnostis Argyriou, Efstathios Giaouris
Summary: The present study investigated the microbial hazards associated with accidental contact with honeybees, wasps, and hornets. Stinging simulation experiments were conducted using live insects collected from Lemnos Island in Greece. The results showed that honeybees did not carry pathogenic bacteria, but wasps and hornets were found to have important indicators of hygiene, suggesting possible contact with fecal material. The differences in microbial communities between honeybees and wasps/hornets, as well as the presence of multidrug-resistant opportunistic pathogens in the latter, raise concerns.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ekaterini Koura, Adamantia Pistikoudi, Margaritis Tsifintaris, George Tsiolas, Evangelia Mouchtaropoulou, Christos Noutsos, Triantafyllos Karantakis, Athanasios Kouras, Athanasios Karanikolas, Anagnostis Argiriou, Irini Nianiou-Obeidat, Photini V. Mylona, Alexios N. Polidoros
Summary: This study explored the impact of seed maturity stages and phosphorus fertilization levels on gene expression in lentils and found that the seed maturity stage significantly influenced phenylpropanoid genes, while phosphorus fertilizer had a targeted effect on specific genes and gene clusters. These findings provide valuable information for enhancing lentil product quality through breeding programs.
APPLIED SCIENCES-BASEL
(2023)
