Bringing androgens up a NOTCH in breast cancer

Cross-regulation between FOXA1 and ErbB2 Signaling in Estrogen Receptor-Negative Breast Cancer

(2015) Ali Naderi et al.   NEOPLASIA

Androgen Receptor Expression Shows Distinctive Significance in ER Positive and Negative Breast Cancers

(2014) Julia Y. S. Tsang et al.   ANNALS OF SURGICAL ONCOLOGY

Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data

(2014) Svasti Haricharan et al.   BREAST CANCER RESEARCH AND TREATMENT

Basal Cell Signaling by p63 Controls Luminal Progenitor Function and Lactation via NRG1

(2014) Nicole Forster et al.   DEVELOPMENTAL CELL

Hyperandrogenemia Predicts Metabolic Phenotype in Polycystic Ovary Syndrome: The Utility of Serum Androstenedione

(2014) Michael W. O'Reilly et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Taxonomy of breast cancer based on normal cell phenotype predicts outcome

(2014) Sandro Santagata et al.   JOURNAL OF CLINICAL INVESTIGATION

Revising the role of the androgen receptor in breast cancer

(2014) F M Fioretti et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

In situ identification of bipotent stem cells in the mammary gland

(2014) Anne C. Rios et al.   NATURE

Androgen Receptor Status Is a Prognostic Marker in Non-Basal Triple Negative Breast Cancers and Determines Novel Therapeutic Options

(2014) Pierluigi Gasparini et al.   PLoS One

Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression

(2014) A. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of the Androgen Receptor, pAkt, and pPTEN in Breast Cancer and Their Potential in Prognostication

(2014) Aisha Sultana et al.   Translational Oncology

Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes

(2013) Anna Barbosa-Desongles et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice

(2013) Xiaobing B. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Expression of androgen receptor and its phosphorylated forms in breast cancer progression

(2013) Qinghu Ren et al.   CANCER

Breast cancer stem cells and epithelial mesenchymal plasticity – Implications for chemoresistance

(2013) Cletus A. Pinto et al.   CANCER LETTERS

Cyclin D1-Dependent Induction of Luminal Inflammatory Breast Tumors by Activated Notch3

(2013) H. Ling et al.   CANCER RESEARCH

Phase II Trial of Bicalutamide in Patients with Androgen Receptor-Positive, Estrogen Receptor-Negative Metastatic Breast Cancer

(2013) A. Gucalp et al.   CLINICAL CANCER RESEARCH

Androgens Up-regulate Transcription of the Notch Inhibitor Numb in C2C12 Myoblasts via Wnt/β-Catenin Signaling to T Cell Factor Elements in the Numb Promoter

(2013) Xin-Hua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch3 marks clonogenic mammary luminal progenitor cells in vivo

(2013) Daniel Lafkas et al.   JOURNAL OF CELL BIOLOGY

Testosterone and Progesterone, But Not Estradiol, Stimulate Muscle Protein Synthesis in Postmenopausal Women

(2013) Gordon I. Smith et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Research Resource: Progesterone Receptor Targetome Underlying Mammary Gland Branching Morphogenesis

(2013) Ashlee R. Lain et al.   MOLECULAR ENDOCRINOLOGY

Progesterone Receptor and Stat5 Signaling Cross Talk Through RANKL in Mammary Epithelial Cells

(2013) Alison E. Obr et al.   MOLECULAR ENDOCRINOLOGY

Involvement of androgens in ovarian health and disease

(2013) M. Lebbe et al.   MOLECULAR HUMAN REPRODUCTION

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages

(2013) Sanja Šale et al.   NATURE CELL BIOLOGY

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

(2013) Weiyi Toy et al.   NATURE GENETICS

The search for ESR1 mutations in breast cancer

(2013) Steffi Oesterreich et al.   NATURE GENETICS

Delayed Puberty and Estrogen Resistance in a Woman with Estrogen Receptor α Variant

(2013) Samuel D. Quaynor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment

(2013) Corinne A. Boulanger et al.   PLoS One

A Prognosis Classifier for Breast Cancer Based on Conserved Gene Regulation between Mammary Gland Development and Tumorigenesis: A Multiscale Statistical Model

(2013) Yingpu Tian et al.   PLoS One

Reduced Androgen Receptor Expression Accelerates the Onset of ERBB2 Induced Breast Tumors in Female Mice

(2013) Myles C. Hodgson et al.   PLoS One

Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation

(2013) Gregorio Chazenbalk et al.   STEROIDS

DAX-1, as an androgen-target gene, inhibits aromatase expression: a novel mechanism blocking estrogen-dependent breast cancer cell proliferation

(2013) M Lanzino et al.   Cell Death & Disease

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells

(2013) J Yun et al.   Oncogenesis

The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

(2013) Nagarajan Kannan et al.   Stem Cell Reports

Wnt-Notch signalling: An integrated mechanism regulating transitions between cell states

(2012) Silvia Muñoz-Descalzo et al.   BIOESSAYS

A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol

(2012) Anna L Hawkes et al.   BMC CANCER

Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity

(2012) Joseph M. Valdez et al.   Cell Stem Cell

Nandrolone, an Anabolic Steroid, Stabilizes Numb Protein Through Inhibition of mdm2 in C2C12 Myoblasts

(2012) X.-H. Liu et al.   JOURNAL OF ANDROLOGY

Androgens Inhibit the Stimulatory Action of 17β-Estradiol on Normal Human Breast Tissue in Explant Cultures

(2012) Natalija Eigėlienė et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Androgen receptor in triple negative breast cancer

(2012) K.M. McNamara et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

(2012) T. E. Hickey et al.   MOLECULAR ENDOCRINOLOGY

Multipotent and unipotent progenitors contribute to prostate postnatal development

(2012) Marielle Ousset et al.   NATURE CELL BIOLOGY

Notch-1 signaling promotes the cyclinD1-dependent generation of mammary tumor-initiating cells that can revert to bi-potential progenitors from which they arise

(2012) H Ling et al.   ONCOGENE

Androgen Receptor Drives Cellular Senescence

(2012) Yelena Mirochnik et al.   PLoS One

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of Wntch signalling and the resolution of transition states in development

(2012) Silvia Muñoz Descalzo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch receptor–ligand binding and activation: Insights from molecular studies

(2012) Chandramouli R. Chillakuri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Elf5 Regulates Mammary Gland Stem/Progenitor Cell Fate by Influencing Notch Signaling

(2012) Rumela Chakrabarti et al.   STEM CELLS

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors

(2012) Ulla Simanainen et al.   Hormones & Cancer

The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells

(2011) Fu-Ning Hsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers

(2011) S. Park et al.   ANNALS OF ONCOLOGY

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

(2011) K Pandya et al.   BRITISH JOURNAL OF CANCER

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

(2011) Min Ni et al.   CANCER CELL

Androgen Receptor Expression and Breast Cancer Survival in Postmenopausal Women

(2011) R. Hu et al.   CLINICAL CANCER RESEARCH

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1

(2011) Jessica L L Robinson et al.   EMBO JOURNAL

Differential Effects of Exogenous Androgen and an Androgen Receptor Antagonist in the Peri- and Postpubertal Murine Mammary Gland

(2011) A. A. Peters et al.   ENDOCRINOLOGY

Repression of Androgen Receptor Activity by HEYL, a Third Member of the Hairy/Enhancer-of-split-related Family of Notch Effectors

(2011) Derek N. Lavery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation

(2011) Zi Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation

(2011) Sanjeev K. Baniwal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of androgens and the androgen receptor in cycling endometrium

(2011) Brianna Cloke et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interplay between progesterone and prolactin in mammary development and implications for breast cancer

(2011) Heather J. Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Distinct stem cells contribute to mammary gland development and maintenance

(2011) Alexandra Van Keymeulen et al.   NATURE

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

(2011) J. M. Haughian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parity-Induced Decrease in Systemic Growth Hormone Alters Mammary Gland Signaling: A Potential Role in Pregnancy Protection from Breast Cancer

(2010) R. K. Dearth et al.   Cancer Prevention Research

Phase II trial of exemestane in combination with fulvestrant in postmenopausal women with hormone responsive advanced breast cancer: no evidence of a pharmacokinetic interaction between exemestane and fulvestrant.

(2010) E Mrozek et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Breast Cancer Stem Cells: Something Out of Notching?

(2010) H. Harrison et al.   CANCER RESEARCH

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

(2010) Ö Yalcin-Ozuysal et al.   CELL DEATH AND DIFFERENTIATION

Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma

(2010) Teresa S Kraus et al.   Diagnostic Pathology

Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression

(2010) Atish Mukherjee et al.   FASEB JOURNAL

Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models

(2010) K. A. Walters et al.   HUMAN REPRODUCTION UPDATE

Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

(2010) H. Al-Hussaini et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element

(2010) M. Lanzino et al.   NUCLEIC ACIDS RESEARCH

Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

(2010) H Ling et al.   ONCOGENE

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity

(2010) Luwei Tao et al.   STEM CELLS

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

(2009) Brenda Cohen et al.   BREAST CANCER RESEARCH AND TREATMENT

Subfertile Female Androgen Receptor Knockout Mice Exhibit Defects in Neuroendocrine Signaling, Intraovarian Function, and Uterine Development But Not Uterine Function

(2009) K. A. Walters et al.   ENDOCRINOLOGY

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways

(2009) Ekaterina L. Kovacheva et al.   ENDOCRINOLOGY

Immunocytochemical Localization of Sex Steroid Hormone Receptors in Normal Human Mammary Gland

(2009) Sijie Li et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Hormone-Responsive Model of Primary Human Breast Epithelium

(2009) J. Dinny Graham et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Testosterone and Depression

(2009) Fahd Aziz Zarrouf et al.   Journal of Psychiatric Practice

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone

(2009) Charles E. Wood et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

A prospective study of the association between endogenous hormones and depressive symptoms in postmenopausal women

(2009) Joanne Ryan et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Notch-1 activates estrogen receptor-α-dependent transcription via IKKα in breast cancer cells

(2009) L Hao et al.   ONCOGENE

The Wnt Receptor, Lrp5, Is Expressed by Mouse Mammary Stem Cells and Is Required to Maintain the Basal Lineage

(2009) Nisha M. Badders et al.   PLoS One

Expression of Androgen Receptor in Mammary Glands in Ovariectomized Cynomolgus Monkeys

(2009) H. Kawaguchi et al.   VETERINARY PATHOLOGY

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

(2008) Howard Kendrick et al.   BMC GENOMICS

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Transcriptome Analysis of the Normal Human Mammary Cell Commitment and Differentiation Process

(2008) Afshin Raouf et al.   Cell Stem Cell

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

ErbB2 Induces Notch1 Activity and Function in Breast Cancer Cells

(2008) Jaime Lindsay et al.   CTS-Clinical and Translational Science

Hormones and Mammary Cell Fate—What Will I Become When I Grow Up?

(2008) Heather L. LaMarca et al.   ENDOCRINOLOGY

Androgen receptor as a target for the treatment of hormone receptor-negative breast cancer: an unchartered territory

(2008) Zeina Nahleh   Future Oncology

A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells

(2008) Anna Grazia Recchia et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers

(2008) Yoshinari Ogawa et al.   International Journal of Clinical Oncology

NUMB controls p53 tumour suppressor activity

(2008) Ivan N. Colaluca et al.   NATURE

The mammary microenvironment alters the differentiation repertoire of neural stem cells

(2008) B. W. Booth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence That an Early Pregnancy Causes a Persistent Decrease in the Number of Functional Mammary Epithelial Stem Cells-Implications for Pregnancy-Induced Protection Against Breast Cancer

(2008) Stefan K. Siwko et al.   STEM CELLS