Review
Oncology
Naoko Honma, Yoko Matsuda, Tetuo Mikami
Summary: TNBC lacks an effective treatment target and is usually associated with a poor clinical outcome due to hormone unresponsiveness. Besides ER-alpha, other sex steroid receptors like AR, ER-beta, and GPER are frequently expressed in TNBC, highlighting the importance of understanding their biological and clinical significance in TNBC. A comprehensive viewpoint on the role of sex steroid hormones in TNBC is crucial for correctly understanding the association between the carcinogenic mechanism or pathobiology of TNBC and sex steroid hormones.
Review
Oncology
Serena Capici, Luca Carlofrancesco Ammoni, Nicole Meli, Viola Cogliati, Francesca Fulvia Pepe, Francesca Piazza, Marina Elena Cazzaniga
Summary: This review focuses on new molecular biomarkers and emerging therapeutic approaches in triple-negative breast cancer (TNBC), providing a general overview of ongoing clinical trials, future perspectives, and differences in approval by American and European regulatory authorities. TNBC is a complex and heterogeneous type of tumor characterized by poor prognosis, aggressive behavior, and lack of effective therapeutic strategies. The identification of new biomarkers and molecular signatures is leading to the development of new therapeutic strategies for TNBC, including immunotherapy, targeted therapy, and antibody-drug conjugates.
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Lijun Yin, Shuo Qi, Zhiqiang Zhu
Summary: An increasing number of studies have shown the crucial roles of androgens and androgen receptors (AR) in regulating glucose and lipid metabolism. Impaired glucose and lipid metabolism and obesity-related diseases have been observed in hypogonadal men and male rodents with androgen deficiency. Exogenous androgens supplementation effectively improves these disorders, but the precise mechanism by which androgens regulate glucose and lipid metabolism remains unclear. Mitochondria, as the powerhouses of cells, play a key role in glucose and lipid metabolism. Existing evidence from pre-clinical and clinical studies suggests that the regulation of glucose and lipid metabolism by androgens/AR is strongly associated with the impact on mitochondrial content and function, but comprehensive reports on the regulatory effect and underlying molecular mechanism are limited. This paper provides a review of the effect of androgens/AR on mitochondrial content, morphology, quality control system, and function, with emphasis on the molecular mechanisms. Additionally, the gender-specific effects of androgens on mitochondria are discussed. This paper lays a theoretical foundation for understanding the influence and mechanism of androgens on glucose and lipid metabolism and highlights the mitochondria-based explanation for the gender-specific effects of androgens on glucose and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiuxiu Li, Michael Berk, Christopher Goins, Mohammad Alyamani, Yoon-Mi Chung, Chenyao Wang, Monaben Patel, Nityam Rathi, Ziqi Zhu, Belinda Willard, Shaun Stauffer, Eric Klein, Nima Sharifi
Summary: Prostate cancer depends on androgens and the androgen receptor (AR). Resistance to medical castration leads to castration-resistant prostate cancer (CRPC) driven by the reactivation of the androgen-AR axis. 3 beta HSD1 plays a critical role in stimulating CRPC and is also essential for breast cancer in postmenopausal women. The phosphorylation of tyrosine 344 (Y344) is required for 3 beta HSD1 activity and the synthesis of androgens and estrogens.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Datu Agasi Mohd Kamal, Siti Fatimah Ibrahim, Azizah Ugusman, Mohd Helmy Mokhtar
Summary: This study found aberrant expression of sex steroid receptors in polycystic ovary syndrome and demonstrated that Kelulut honey treatment can normalize the expression of these receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sergey Vtorushin, Anastasia Dulesova, Nadezhda Krakhmal
Summary: Triple-negative breast cancer is a heterogeneous group of malignant tumors with four specific subtypes. The basal-like subtype is the most common, accounting for 80% of all cases. Despite the lower proportions of mesenchymal and LAR variants, they exhibit aggressive biological behavior.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Oncology
Yuichiro Kanno, Nao Saito, Ryota Saito, Tomohiro Kosuge, Ryota Shizu, Tomofumi Yatsu, Takuomi Hosaka, Kiyomitsu Nemoto, Keisuke Kato, Kouichi Yoshinari
Summary: This study investigated the selective mechanism of selective androgen receptor modulators (SARMs) using the synthetic steroid YK11. The results suggested that gene selective regulation by SARMs is achieved through differential DNA-binding and/or cofactor recruitment by ligands. These findings provide novel insights into the mechanism of action of SARMs.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Savitha Rajarajan, V. P. Snijesh, C. E. Anupama, Madhumathy G. Nair, Apoorva Mavatkar, Chandrakala M. Naidu, Sharada Patil, Vidya P. Nimbalkar, Annie Alexander, Maalavika Pillai, Mohit Kumar Jolly, Radhakrishnan Sabarinathan, Rakesh S. Ramesh, Srinath Bs, Jyothi S. Prabhu
Summary: The role of androgen receptor (AR) in breast cancer (BC) is controversial, and it may differ in hormone receptor positive BC and triple negative BC (TNBC). This study examined the utility of an AR regulated gene score in BC subtypes and found that high gene score was associated with better clinical parameters and survival in BC, as well as with epithelial to mesenchymal transition (EMT) markers in TNBC.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Florian Le Billan, Gloria Umogbai, Carolyn L. Cummins
Summary: Steroid hormones not only regulate gene transcription but also modulate the alternative splicing of pre-mRNA, acting through binding to nuclear receptors. The effect of steroid hormones on alternative splicing is time-, gene-, and tissue-specific. Mechanisms by which steroid hormones regulate alternative splicing include the recruitment of dual-function proteins, transcriptional regulation of splicing factor levels, alternative splicing of splicing factors or transcription factors, and regulation of elongation rate.
Article
Oncology
Lei Zhang, JinFeng Wu, QiuMei Wu, XiangJuan Zhang, ShuaiCai Lin, WanLi Ran, Li Zhu, ChengYan Tang, Xing Wang
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms behind male propensity in HCC incidence, prognosis, and treatment responses are complex and inconclusive. This review integrates current knowledge on how hormones regulate HCC development in a sexually dimorphic manner. Understanding the role of sex hormones in HCC may lead to personalized therapeutic strategies in high-risk populations.
Article
Cell Biology
Charlene Thiebaut, Virginie Vlaeminck-Guillem, Olivier Tredan, Coralie Poulard, Muriel Le Romancer
Summary: Steroid receptors play a crucial role in regulating cellular responses to steroids through both genomic and non-genomic signaling pathways. Research on non-genomic signaling in breast and prostate cancers has shown its clinical importance and potential for developing therapeutic strategies. Understanding the non-genomic pathways of ER, PR, AR, and GR may offer new perspectives for cancer treatment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Li Rebekah Feng, Jennifer J. Barb, Hannah Allen, Jeniece Regan, Leorey Saligan
Summary: This study found that patients with non-metastatic prostate cancer receiving neoadjuvant ADT reported more severe fatigue, possibly due to alterations in steroid hormone biosynthesis pathways related to sleep-related impairment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Mohd A. Beg, Md A. Beg, Ummer R. Zargar, Ishfaq A. Sheikh, Osama S. Bajouh, Adel M. Abuzenadah, Mohd Rehan
Summary: Organotin compounds (OTCs) are widely used as polyvinyl chloride stabilizers and marine antifouling biocides. They have metabolic and endocrine disrupting effects in organisms and may interfere with natural steroid/receptor binding and perturb steroid signaling.
Review
Oncology
Wojciech Kowalczyk, Grzegorz Waliszczak, Robert Jach, Joanna Dulinska-Litewka
Summary: Our knowledge of steroid receptor function in breast cancer is vast and constantly evolving. The family of steroid receptors plays a crucial role in the pathogenesis of the disease, regulating gene expression and interacting with other proteins. Understanding their complex nature is essential for the development of effective hormone therapies targeting breast cancer.
Article
Oncology
Keely M. McNamara, Fouzia Guestini, Torill Sauer, Joel Touma, Ida Rashida Bukholm, Jonas C. Lindstrom, Hironobu Sasano, Jurgen Geisler
BRITISH JOURNAL OF CANCER
(2018)
Article
Oncology
Kyoko Kikuchi, Keely May McNamara, Yasuhiro Miki, Erina Iwabuchi, Ayako Kanai, Minoru Miyashita, Takanori Ishida, Hironobu Sasano
Article
Oncology
Fouzia Guestini, Katsuhiko Ono, Minoru Miyashita, Takanori Ishida, Noriaki Ohuchi, Saki Nakagawa, Hisashi Hirakawa, Kentaro Tamaki, Yasuyo Ohi, Yoshiaki Rai, Yasuaki Sagara, Hironobu Sasano, Keely May McNamara
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Review
Cell Biology
Keely May McNamara, Hironobu Sasano
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Michael Ulm, Arvind V. Ramesh, Keely M. McNamara, Suriyan Ponnusamy, Hironobu Sasano, Ramesh Narayanan
ENDOCRINE CONNECTIONS
(2019)
Article
Pathology
Yasuhiro Nakamura, Kazue Ise, Keely May McNamara, Abdullah Azmahani, Shun Sato, Fumiyoshi Fujishima, Kensuke Joh, Hiroyoshi Suzuki, Koji Mitsuzuka, Yoichi Arai, Hiroyuki Takahashi, Hironobu Sasano
Article
Oncology
Ayako Kanai, Keely May McNamara, Erina Iwabuchi, Yasuhiro Miki, Yoshiaki Onodera, Fouzia Guestini, Freeha Khalid, Yasuaki Sagara, Yasuyo Ohi, Yoshiaki Rai, Rin Yamaguchi, Maki Tanaka, Minoru Miyashita, Takanori Ishida, Hironobu Sasano
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Article
Oncology
Yu Pan, Xiuli Wang, Yanzhi Zhang, Juanjuan Qiao, Hironobu Sasano, Keely McNamara, Baoshan Zhao, Dongmei Zhang, Yuhua Fan, Lili Liu, Xueling Jia, Ming Liu, Sihang Song, Lin Wang
Meeting Abstract
Oncology
Naoko Takigami, Kentaro Tamaki, Yoshihiko Kamada, Kano Uehara, Seiko Tsuchiya, Shigeharu Terukina, Takanori Ishida, Minoru Miyashita, Keely May McNamara, Hironobu Sasano, Nobumitsu Tamaki
Meeting Abstract
Oncology
Naoko Takigami, Shimpei Kuniyoshi, Yasuhiko Miki, Kentaro Tamaki, Yoshihiko Kamada, Kano Uehara, Seiko Tsuchiya, Shigeharu Terukina, Takanori Ishida, Minoru Miyashita, Ayako Kanai, Keely May McNamara, Nobumitsu Tamaki, Hironobu Sasano
Article
Multidisciplinary Sciences
Suriyan Ponnusamy, Sarah Asemota, Lee S. Schwartzberg, Fouzia Guestini, Keely M. McNamara, Mariaelena Pierobon, Alba Font-Tello, Xintao Qiu, Yingtian Xie, Prakash K. Rao, Thirumagal Thiyagarajan, Brandy Grimes, Daniel L. Johnson, Martin D. Fleming, Frances E. Pritchard, Michael P. Berry, Roy Oswaks, Richard E. Fine, Myles Brown, Hironobu Sasano, Emanuel F. Petricoin, Henry W. Long, Ramesh Narayanan
Meeting Abstract
Oncology
Kentaro Tamaki, Mustuyo Takaesu, Sayaka Nagamine, Shigeharu Terukina, Yoshihiko Kamada, Kano Uehara, Naoko Takigami, Miwa Arakaki, Kazuko Yamashiro, Minoru Miyashita, Takanori Ishida, Keely May McNamara, Nobumitsu Tamaki, Hironobu Sasano
Meeting Abstract
Oncology
Hiroyuki Ueno, Shinkichi Kosaka, Takanori Isida, Minoru Miyashita, Ayako Kanai, Ju-Yoen Moon, Man Ho Choi, Keely McNamara, Hironobu Sasano
Meeting Abstract
Oncology
Rina Kumata, Keely M. McNamara, Ayako Kanai, Yoshiaki Onodera, Kyoko Kikuchi, Minoru Miyashita, Yasuaki Sagara, Yoshiaki Rai, Yasuyo Ohi, Rin Yamaguchi, Takanori Ishida, Noriaki Ofuchi, Hironobu Sasano
Meeting Abstract
Oncology
Kyoko Kikuchi, Keely M. McNamara, Yasuhiro Miki, Erina Iwabuchi, Minoru Mitashita, Takanori Ishida, Noriaki Ohuchi, Hironobu Sasano
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)