Enzymatic features of the glucose metabolism in tumor cells

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia induces differential translation of enolase/MBP-1

(2010) Kara C Sedoris et al.   BMC CANCER

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

(2010) H. Liu et al.   CANCER RESEARCH

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma

(2010) Céline Pinheiro et al.   HISTOPATHOLOGY

Energy Restriction as an Antitumor Target of Thiazolidinediones

(2010) Shuo Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

(2010) Jean-Pierre Bayley et al.   LANCET ONCOLOGY

Glycogen synthase kinase 3 beta: can it be a target for oral cancer

(2010) Rajakishore Mishra   Molecular Cancer

Point: Hypotheses first

(2010) Robert Weinberg   NATURE

Modeling Core Metabolism in Cancer Cells: Surveying the Topology Underlying the Warburg Effect

(2010) Osbaldo Resendis-Antonio et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo

(2010) Qing Zhu et al.   PROSTATE

Clinical mutants of human glucose 6-phosphate dehydrogenase: Impairment of NADP+ binding affects both folding and stability

(2009) Xiao-Tao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Glycogen synthase kinase 3: more than a namesake

(2009) Geetha Vani Rayasam et al.   BRITISH JOURNAL OF PHARMACOLOGY

A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative Stress

(2009) Danyi Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

Detection of autoantibodies against cyclophilin A and triosephosphate isomerase in sera from breast cancer patients by proteomic analysis

(2009) Michiko Sato Tamesa et al.   ELECTROPHORESIS

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws - a promising method for speeding up the kinetic modelling of complex metabolic networks

(2009) Sascha Bulik et al.   FEBS Journal

Kinetics of transport and phosphorylation of glucose in cancer cells

(2009) Sara Rodríguez-Enríquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Glyceraldehyde-3-phosphate, a glycolytic intermediate, plays a key role in controlling cell fate via inhibition of caspase activity

(2009) Mi Jang et al.   MOLECULES AND CELLS

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p

(2009) J. F. Moxley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

(2008) Satish Patel et al.   CANCER CELL

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

The Warburg Effect in Leukemia-Stroma Cocultures Is Mediated by Mitochondrial Uncoupling Associated with Uncoupling Protein 2 Activation

(2008) I. Samudio et al.   CANCER RESEARCH

Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver

(2008) Wilma M. Frederiks et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of triosephosphate isomerase as an anti-drug resistance agent in human gastric cancer cells using functional proteomic analysis

(2008) Xin Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review

(2008) Mahdi Aghili et al.   JOURNAL OF NEURO-ONCOLOGY

Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies

(2008) Raja Venkatasubramanian et al.   JOURNAL OF THEORETICAL BIOLOGY

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Silencing of the Candidate Tumor Suppressor Gene Solute Carrier Family 5 Member 8 (SLC5A8) in Human Pancreatic Cancer

(2008) Jong Y. Park et al.   PANCREAS

Proteomic Analysis of Pancreatic Ductal Adenocarcinoma Compared with Normal Adjacent Pancreatic Tissue and Pancreatic Benign Cystadenoma

(2008) Yazhou Cui et al.   PANCREATOLOGY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

(2008) Céline Pinheiro et al.   VIRCHOWS ARCHIV

Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck

(2008) Patricia V. Basta et al.   Cancer Detection and Prevention

Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells

(2007) Hwa Jung Choi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY