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Title
Selective killing of p53-deficient cancer cells by SP600125
Authors
Keywords
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Journal
EMBO Molecular Medicine
Volume 4, Issue 6, Pages 500-514
Publisher
EMBO
Online
2012-03-23
DOI
10.1002/emmm.201200228
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Note: Only part of the references are listed.- The Causes and Consequences of Polyploidy in Normal Development and Cancer
- (2011) Teresa Davoli et al. Annual Review of Cell and Developmental Biology
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- (2011) Ilio Vitale et al. CELL CYCLE
- Pharmacological Activation of p53 in Cancer Cells
- (2011) Mohammad Athar et al. CURRENT PHARMACEUTICAL DESIGN
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- (2011) Ilio Vitale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2010) R. Colombo et al. CANCER RESEARCH
- Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
- (2010) Ilio Vitale et al. EMBO JOURNAL
- Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
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- (2010) Laura Hewitt et al. JOURNAL OF CELL BIOLOGY
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- (2010) Sarah L. Thompson et al. JOURNAL OF CELL BIOLOGY
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- (2010) Y. Degenhardt et al. MOLECULAR CANCER THERAPEUTICS
- Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
- (2010) Nicholas Kwiatkowski et al. Nature Chemical Biology
- Translating p53 into the clinic
- (2010) Chit Fang Cheok et al. Nature Reviews Clinical Oncology
- SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
- (2010) J A Kim et al. ONCOGENE
- Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
- (2010) K G Wiman ONCOGENE
- Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis
- (2010) Tale Sliedrecht et al. PLoS One
- Therapeutic targeting of p53 by small molecules
- (2010) Galina Selivanova SEMINARS IN CANCER BIOLOGY
- Transcriptional Regulation by P53
- (2010) R. Beckerman et al. Cold Spring Harbor Perspectives in Biology
- An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe
- (2010) S Rello-Varona et al. Cell Death & Disease
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
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- Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
- (2009) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
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- (2009) Douglas R. Green et al. NATURE
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- (2009) K A Olaussen et al. ONCOGENE
- A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
- (2009) S. Sur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) Sanjeev Shangary et al. Annual Review of Pharmacology and Toxicology
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- (2008) Matthew L. H. Chu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation
- (2008) Quanbin Xu et al. MOLECULAR BIOLOGY OF THE CELL
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- (2008) S Finkin et al. ONCOGENE
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