Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

(2012) Fei Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody

(2011) David Capper et al.   ACTA NEUROPATHOLOGICA

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

(2011) Genevieve Schindler et al.   ACTA NEUROPATHOLOGICA

Mutant BRAF Melanomas—Dependence and Resistance

(2011) Poulikos I. Poulikakos et al.   CANCER CELL

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

(2011) Ricarda Herr et al.   Cell Communication and Signaling

Biology using engineering tools

(2011) Marc R. Birtwistle et al.   CELL CYCLE

Skin Tumors Induced by Sorafenib; Paradoxic RAS-RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1

(2011) J. P. Arnault et al.   CLINICAL CANCER RESEARCH

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

(2011) Melissa M. McKay et al.   CURRENT BIOLOGY

Single Substitution within the RKTR Motif Impairs Kinase Activity but Promotes Dimerization of RAF Kinase

(2011) Angela Baljuls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma

(2011) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1

(2011) S Huber et al.   LEUKEMIA

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

(2011) R. Fritsche-Guenther et al.   Molecular Systems Biology

A drug-resistant duo

(2011) Hugo Lavoie et al.   NATURE

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Targeting RAF: trials and tribulations

(2011) Julian Downward   NATURE MEDICINE

BRAF targeted therapy changes the treatment paradigm in melanoma

(2011) Antoni Ribas et al.   Nature Reviews Clinical Oncology

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis

(2011) Guillaume Gauchotte et al.   PATHOLOGY

Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

(2011) A. S. Little et al.   Science Signaling

The Raf Inhibitor Paradox: Unexpected Consequences of Targeted Drugs

(2010) Adrienne D. Cox et al.   CANCER CELL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

(2010) Anja E. Eisenhardt et al.   INTERNATIONAL JOURNAL OF CANCER

How melanomas bypass new therapy

(2010) David Solit et al.   NATURE

Drug discovery: Inhibitors that activate

(2010) Karen Cichowski et al.   NATURE

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells

(2010) F M Kaplan et al.   ONCOGENE

BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation

(2010) R. B. Corcoran et al.   Science Signaling

Partner exchange: protein–protein interactions in the Raf pathway

(2010) Reiner Wimmer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation

(2009) S. C. Brady et al.   CANCER RESEARCH

GermlineBRAFmutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum

(2009) Anna Sarkozy et al.   HUMAN MUTATION

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

(2009) D. A. Ritt et al.   MOLECULAR AND CELLULAR BIOLOGY

MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib

(2009) R. Houben et al.   MOLECULAR CANCER THERAPEUTICS

Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma

(2009) William M. Old et al.   MOLECULAR CELL

C-Raf Inhibits MAPK Activation and Transformation by B-RafV600E

(2009) Florian A. Karreth et al.   MOLECULAR CELL

Theoretical and experimental analysis links isoform- specific ERK signalling to cell fate decisions

(2009) Marcel Schilling et al.   Molecular Systems Biology

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

(2009) J. Yu et al.   NEUROLOGY

Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

(2009) D T W Jones et al.   ONCOGENE

Resequencing Analysis of the Human Tyrosine Kinase Gene Family in Pancreatic Cancer

(2009) Takashi Kubo et al.   PANCREAS

B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival

(2008) Paulo Matos et al.   GASTROENTEROLOGY

Regulation of RAF Activity by 14-3-3 Proteins

(2008) Andreas Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

(2008) Aron B. Jaffe et al.   JOURNAL OF CELL BIOLOGY

CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation

(2008) Catherine Noble et al.   MOLECULAR CELL

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA