Single Substitution within the RKTR Motif Impairs Kinase Activity but Promotes Dimerization of RAF Kinase

RAF protein-serine/threonine kinases: Structure and regulation

(2010) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Raf Inhibitor Paradox: Unexpected Consequences of Targeted Drugs

(2010) Adrienne D. Cox et al.   CANCER CELL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Identification of Novelin VivoPhosphorylation Sites of the Human Proapoptotic Protein BAD

(2009) Lisa Polzien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

(2009) D. A. Ritt et al.   MOLECULAR AND CELLULAR BIOLOGY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

A-RAF Kinase Functions in ARF6 Regulated Endocytic Membrane Traffic

(2009) Elena Nekhoroshkova et al.   PLoS One

Positive Regulation of A-RAF by Phosphorylation of Isoform-specific Hinge Segment and Identification of Novel Phosphorylation Sites

(2008) Angela Baljuls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY