In vitro approaches to studying the metabolism of new psychoactive compounds

Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse

(2011) Markus R Meyer et al.   PHARMACOGENOMICS

Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases

(2011) Andrea E. Schwaninger et al.   TOXICOLOGY LETTERS

In vitro phase I metabolism of the synthetic cannabimimetic JWH-018

(2010) Annette Wintermeyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Convenient Gram-Scale Metabolite Synthesis by Engineered Fission Yeast Strains Expressing Functional Human P450 Systems

(2010) Călin-Aurel Drăgan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Metabolism of Designer Drugs of Abuse: An Updated Review

(2010) Markus R. Meyer et al.   CURRENT DRUG METABOLISM

Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS

(2010) Markus R. Meyer et al.   JOURNAL OF MASS SPECTROMETRY

Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MPDV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry

(2010) Sabina Strano-Rossi et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

(2010) Andy Zöllner et al.   Bioanalysis

Stereoselective differences in the cytochrome P450-dependent dealkylation and demethylenation of N-methyl-benzodioxolyl-butanamine (MBDB, Eden) enantiomers

(2009) Markus R. Meyer et al.   BIOCHEMICAL PHARMACOLOGY

4-Hydroxy-3-methoxymethamphetamine Glucuronide as a Phase II Metabolite of 3,4-Methylenedioxymethamphetamine: Enzyme-Assisted Synthesis and Involvement of Human Hepatic Uridine 5′-Diphosphate-Glucuronosyltransferase 2B15 in the Glucuronidation

(2009) Takuji Shoda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Enantioselectivity in the Methylation of the Catecholic Phase I Metabolites of Methylenedioxy Designer Drugs and Their Capability To Inhibit Catechol-O-methyltransferase-Catalyzed Dopamine 3-Methylation

(2009) Markus R. Meyer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids

(2009) A. Mazur et al.   DRUG METABOLISM AND DISPOSITION

The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxyethylamphetamine and Its Single Enantiomers

(2009) M. R. Meyer et al.   DRUG METABOLISM AND DISPOSITION

Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry

(2009) S. C. Turfus et al.   DRUG METABOLISM AND DISPOSITION

Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes

(2009) K. Rouguieg et al.   DRUG METABOLISM AND DISPOSITION

The Role of Human UDP-Glucuronyltransferases on the Formation of the Methylenedioxymethamphetamine (Ecstasy) Phase II Metabolites R- and S-3-Methoxymethamphetamine 4-O-Glucuronides

(2009) A. E. Schwaninger et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen

(2009) Zeynep S. Teksin et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine

(2009) Frank T. Peters et al.   FORENSIC SCIENCE INTERNATIONAL

New designer drug α‐pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques

(2009) Christoph Sauer et al.   JOURNAL OF MASS SPECTROMETRY

Studies on the metabolism of mitragynine, the main alkaloid of the herbal drug Kratom, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry

(2009) Anika A. Philipp et al.   JOURNAL OF MASS SPECTROMETRY

Investigations on the human hepatic cytochrome P450 isozymes involved in the metabolism of 3,4-methylenedioxy-amphetamine (MDA) and benzodioxolyl-butanamine (BDB) enantiomers

(2009) Markus R. Meyer et al.   TOXICOLOGY LETTERS

Flavin-containing monooxygenase 1-catalysedN,N-dimethylamphetamineN-oxidation

(2009) S. K. Lee et al.   XENOBIOTICA

Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

(2009) Frank T Peters et al.   Bioanalysis

Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugs N-(1-phenyl cyclohexyl)-2-ethoxyethanamine and N-(1-phenylcyclohexyl)-2-methoxyethanamine

(2008) Christoph Sauer et al.   BIOCHEMICAL PHARMACOLOGY

Identification of Cytochrome P450 Enzymes Involved in the Metabolism of the Designer DrugsN-(1-Phenylcyclohexyl)-3-ethoxypropanamine andN-(1-Phenylcyclohexyl)-3-methoxypropanamine

(2008) Christoph Sauer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolic Stability: Main Enzymes Involved and Best Tools To Assess It

(2008) Romuald Laine   CURRENT DRUG METABOLISM

The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers

(2008) M. R. Meyer et al.   DRUG METABOLISM AND DISPOSITION

2,5-Dimethoxyamphetamine-derived designer drugs: Studies on the identification of cytochrome P450 (CYP) isoenzymes involved in formation of their main metabolites and on their capability to inhibit CYP2D6

(2008) A EWALD et al.   TOXICOLOGY LETTERS

Designer drug 2,5-dimethoxy-4-methyl-amphetamine (DOM, STP): Involvement of the cytochrome P450 isoenzymes in formation of its main metabolite and detection of the latter in rat urine as proof of a drug intake using gas chromatography–mass spectrometry

(2007) Andreas H. Ewald et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

New designer drugsN-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) andN-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques

(2007) Christoph Sauer et al.   JOURNAL OF MASS SPECTROMETRY