Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway

Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway

(2015) Meng Lu et al.   BIOCHEMICAL PHARMACOLOGY

Toll-like receptor 2: therapeutic target for gastric carcinogenesis

(2015) William McCormack et al.   Oncotarget

Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells

(2014) Hai-ying Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber ‘cell highways’

(2014) Mark Tyler Nelson et al.   BMC CANCER

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer

(2014) Jacqueline Banyard et al.   BMC CANCER

Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species

(2014) Mu-Jang Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway

(2014) Xudong Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Proteasome inhibitor MG132 enhances the antigrowth and antimetastasis effects of radiation in human nonsmall cell lung cancer cells

(2014) Jing Liu et al.   TUMOR BIOLOGY

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

(2013) Zeze Fu et al.   BMC CANCER

Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent

(2013) Changmin Chen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Shikonin Suppresses the Migratory Ability of Hepatocellular Carcinoma Cells

(2013) Po-Li Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Shikonin Inhibits Thyroid Cancer Cell Growth and Invasiveness Through Targeting Major Signaling Pathways

(2013) Qi Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The regulation of toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells

(2013) Haiyan Guo et al.   Molecular Cancer

Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway

(2013) Heyong Wang et al.   TOXICOLOGY

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation

(2012) Hazel Tye et al.   CANCER CELL

Profiles of Gene Polymorphisms in Cytokines and Toll-Like Receptors with Higher Risk for Gastric Cancer

(2012) Juliana Garcia de Oliveira et al.   DIGESTIVE DISEASES AND SCIENCES

Induction of matrix metalloproteinases and TLR2 and 6 in murine colon after oral exposure to Mycobacterium avium subsp. paratuberculosis

(2012) Martin Roderfeld et al.   MICROBES AND INFECTION

The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway

(2012) Bo Zhang et al.   Oxidative Medicine and Cellular Longevity

Polymorphisms of theTLR2andTLR4genes are associated with risk of gastric cancer in a Brazilian population

(2012) Juliana Garcia de Oliveira   WORLD JOURNAL OF GASTROENTEROLOGY

Histologic and Immunohistochemical Analyses of α-Fetoprotein—Producing Cancer of the Stomach

(2011) Tetsu Kinjo et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population

(2011) H.-M. Zeng et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Gastric cancer — The role of matrix metalloproteinases in tumor progression

(2011) Marta Łukaszewicz-Zając et al.   CLINICA CHIMICA ACTA

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

MMP-2 as a Putative Biomarker for Carcinomatosis in Gastric Cancer

(2011) Sewon Noh et al.   HEPATO-GASTROENTEROLOGY

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells

(2010) R Min et al.   ORAL DISEASES

Factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in Brazil

(2009) Marcello F. Fanelli et al.   International Journal of Clinical Oncology

Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS

(2008) Diya Zhang et al.   Innate Immunity

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE