Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mao Li, Zi-xin Wan, Yue-yang Tang, Xin-hua Liang, Ya-ling Tang
Summary: Immunohistochemical staining was used to detect the expression of TIM-3, Gal-9, and CD160 in SACC and their correlation with clinicopathological characteristics. The results showed that overexpression of TIM-3 and CD160 were associated with SACC recurrence, while high expression of Gal-9 was correlated with pathological classification. The average percentage of TILs in SACC was 18.2%, with a higher occurrence in minor salivary glands. There were positive correlations observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells and TILs. These findings suggest that the density of TILs and the expression of TIM-3, Gal-9, and CD160 could be potential therapeutic targets in SACC.
Article
Pathology
Hanna Hametoja, Antti Makitie, Leif Back, Ilmo Leivo, Caj Haglund, Timo Sorsa, Jaana Hagstrom
Summary: In this study on adenoid cystic carcinoma (ACC), the expression of MMP-9 in pseudocysts and peritumoural inflammatory cells was found to be associated with better survival and fewer treatment failures. High tumoural MMP-7 and-25 were linked to better survival, while high tumoural MMP-15 was associated with poorer survival and high tumoural MMP-9 with advanced stage and regional recurrences. Tumour cells did not show MMP-8 immunopositivity. These results suggest potential roles for MMPs in ACC carcinogenesis and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Oncology
Carlos A. Rodriguez-Russo, Jacqueline C. Junn, Sue S. Yom, Richard L. Bakst
Summary: Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck region with a high propensity for perineural invasion, often necessitating a balance between disease burden and treatment morbidity. Radiotherapy plays a crucial role in improving local control and managing unresectable disease, particularly in cases of perineural invasion. Target delineation and treatment regimens in different settings, including definitive, recurrent, and metastatic disease, are important considerations in the management of ACC.
Article
Geriatrics & Gerontology
Chuan Ze Liu, Da Shuai Guo, Jian Jun Ma, Lin Rui Dong, Qing Qing Chang, Hong Qi Yang, Ke Ke Liang, Xiao Huan Li, Da Wei Yang, Yong Yan Fan, Qi Gu, Si Yuan Chen, Dong Sheng Li
Summary: This study found that serum MMP3 levels were lower and MMP9 levels were higher in patients with Parkinson's disease (PD) compared to healthy controls. Serum MMP3 levels were correlated with non-motor symptoms and sleep disturbance in PD patients, while MMP9 levels were correlated with non-motor symptoms and cognitive function in PD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Xi Rui, Zixian Huang, Rui Chen, Yongju Chen, Yan Wang, Zhiquan Huang
Summary: The high expression of RPS3 in ACC is associated with metastasis and poor prognosis, with its regulation of the STAT1/NF-kB signaling pathway impacting migration, invasion, and chemoresistance in ACC. RPS3 may serve as a novel therapeutic target for ACC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Sana Abdul Khaliq, Zobia Umair, Mi-Ock Baek, Seung Joo Chon, Mee-Sup Yoon
Summary: The level of C-peptide is critical for the migration of undecidualized endometrial stromal cells and is associated with the failure rate of trophoblast invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Mark Zupancic, Anders Nasman, Anders Berglund, Tina Dalianis, Signe Friesland
Summary: Adenoid cystic carcinoma (AdCC) is a rare heterogeneous disease that is difficult to diagnose and predict prognosis, making treatment challenging. A retrospective study on a large cohort of AdCC patients in the head and neck revealed that early disease stage and major salivary gland subsite were favorable prognostic factors, while perineural invasion and radical surgery did not significantly correlate with survival. These findings have important implications for prognostic assessment of AdCC.
Article
Biochemistry & Molecular Biology
Zi-Lu Huang, Aalaa Sanad Abdallah, Guang-Xin Shen, Milagros Suarez, Ping Feng, Yan-Jiao Yu, Ying Wang, Shuo-Han Zheng, Yu-Jun Hu, Xiang Xiao, Ya Liu, Song-Ran Liu, Zhong-Ping Chen, Xiao-Nan Li, Yun-Fei Xia
Summary: This study investigated the role of GDP-mannose pyrophosphorylase B (GMPPB) in glioblastoma multiforme (GBM). The results showed that GMPPB expression was correlated with the WHO grade and prognosis of GBM, and silencing GMPPB inhibited the proliferation, migration, and invasion of GBM cells. Furthermore, the Hippo/MMP3 axis was identified as essential for GMPPB-promoted GBM aggressiveness. These findings suggest that GMPPB could be a potential novel target for GBM treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Wen Li, Qian Zhang, Xiaobin Wang, Hanlin Wang, Wenxin Zuo, Hongliang Xie, Jianming Tang, Mengmeng Wang, Zhipeng Zeng, Wanxia Cai, Donge Tang, Yong Dai
Summary: This study utilized mass spectrometry-based quantitative proteomics to analyze protein expression profiles in oral ACC patients, identifying potential biomarkers and providing insights into the pathogenesis of OACC from a proteomics perspective. The findings offer valuable information for early detection, diagnosis, treatment, and prognosis in OACC patients.
Article
Oncology
Yan Fang, Zhouying Peng, Yumin Wang, Kelei Gao, Yalan Liu, Ruohao Fan, Hua Zhang, Zhihai Xie, Weihong Jiang
Summary: Adenoid cystic carcinoma (ACC) is a rare malignant tumor derived mainly from the salivary glands that displays contradictory characteristics of slow growth but aggressive progression. ACC of the head and neck (ACCHN) has a propensity for perineural invasion and is challenging to treat. This review aims to provide updated insights into ACCHN and discuss imaging diagnosis, pathological features, and therapeutic strategies.
Article
Oncology
Ke Wang, Hua-Yang Fan, Xing Pang, Mei Zhang, Xiang-Hua Yu, Jia-Shun Wu, Bing-Jun Chen, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Summary: High expression of Dll4 is associated with invasive front of SACC, solid tumor type, high TNM grade, and high metastasis and recurrence rates. Notch1 and Dll4 are positively correlated at the invasive front, with leader cells showing high Dll4 expression and follower cells showing high Notch1 expression in a 3D culture model. Silencing Dll4 reduces migration and invasion of SACC cells, but overexpression of Notch1 can rescue these abilities. Dll4/Notch1 signaling pathway may play a role in collective invasion of SACC and could be a potential target for SACC treatment.
Article
Cell Biology
Mei Zhang, Jia-Shun Wu, Hong-Chun Xian, Bing-Jun Chen, Hao-Fan Wang, Xiang-Hua Yu, Xin Pang, Li Dai, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Summary: Our study confirmed the role of CXCR5 in SACC, facilitating PNI by downregulating miR-187 to disinhibit S100A4 expression.
Article
Clinical Neurology
Gao-Jian Su, Di Zhang, Jia-Nuo Wu, Yu-Hang Deng, Chu-Wei Wu, Xie-Jun Zhang, Xian-Jian Huang
Summary: This study investigated the expression of matrix metallopeptidase (MMP)-8 and MMP-9 in chronic subdural hematoma (CSDH) and found that they may play a role in its development. The concentration of MMP-8 was higher in normal individuals compared to preoperative and postoperative groups, while the concentration of MMP-9 was lower in normal individuals compared to both preoperative and postoperative groups. Immunohistochemistry confirmed the expression of MMP-8 and MMP-9 in CSDH membranes, suggesting angiogenesis in CSDH formation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Yaguang Wang, Di Wang, Chao Wu, Bin Wang, Shufang He, Hua Wang, Gaolin Liang, Ye Zhang
Summary: The study developed a peptide K2 to encapsulate bFGF and proposed an EISA strategy to slowly release bFGF in ischemic myocardium. Results showed that bFGF@K2 micelle exerted a stronger cardioprotective effect than free bFGF in a rat model of myocardial ischemia-reperfusion, potentially offering a promising treatment strategy for MI in the future.