Article
Biochemistry & Molecular Biology
Hadar Golan Berman, Pooja Chauhan, Shira Shalev, Hiba Hassanain, Avital Parnas, Sheera Adar
Summary: The study identified that in a specific cell line system, cisplatin resistant cells had less damage but similar repair kinetics. Through mapping gene expression changes, 56 upregulated genes were identified that could potentially impact the response to cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mara De Marco Zompit, Monica Torres Esteban, Clemence Mooser, Salome Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Summary: In this study, CIP2A is identified as a protein that interacts with TOPBP1 and specifically regulates its localization in mitosis. Cells lacking CIP2A show increased radio-sensitivity, micronuclei formation, and chromosomal instability.
NATURE COMMUNICATIONS
(2022)
Review
Genetics & Heredity
Yongxin Li, Yan Tong, Jiaqi Liu, Jianlin Lou
Summary: DNA is crucial for organism development and function. MiRNA, a type of non-coding RNA, may play an important role in the DNA damage response by influencing processes like cell cycle, DNA repair, and apoptosis, thereby impacting genomic stability and tumorigenesis.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Jung Min Kim
Summary: Microtubules are key components of the cytoskeleton and play important roles in cellular processes and genome maintenance. This review highlights recent advances in understanding the role of microtubule dynamics in DNA damage response and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
John M. M. Danforth, Luc Provencher, Aaron A. A. Goodarzi
Summary: Exposure to environmental ionizing radiation, particularly high-LET radiation, can induce clustered DNA damage that is challenging to repair. Understanding the role of chromatin in the repair process is essential for assessing the effects of radiation exposure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Xuemei Cao, Cansu Kose, Christopher P. Selby, Aziz Sancar
Summary: The XR-seq method is widely used for mapping nucleotide excision repair genome-wide. It captures and sequences excised oligomers carrying DNA damage, and aligns their sequences to the genome. Researchers have successfully used ultraviolet light-irradiated plasmids as substrates for repair experiments in Escherichia coli and mammals, and found common excision product characteristics in both systems. This approach helps understand the effects of epigenetics and other cellular factors on DNA repair.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Miyu Sekiguchi, Nobuko Matsushita
Summary: This article provides a comprehensive overview of the role and regulatory mechanism of histone ubiquitination in DNA double-strand break repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Jack Wootton, Evi Soutoglou
Summary: The review discusses how chromatin and nuclear environment play key roles in the regulation of eukaryotic genome replication, covering aspects such as higher order organization of the genome, local chromatin environment, and spatial organization of stalled replication forks for resolving replication stress.
FRONTIERS IN GENETICS
(2021)
Review
Biotechnology & Applied Microbiology
Maddalena Mognato, Susanne Burdak-Rothkamm, Kai Rothkamm
Summary: The translated article discusses the complex relationship between DNA replication stress, DDR signaling, and genome integrity in mammalian cells, with a focus on the role of chromatin disposition as an important modulator of DNA repair. It reviews recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dimitra T. Stefanou, Marousa Kouvela, Dimitris Stellas, Konstantinos Voutetakis, Olga Papadodima, Konstantinos Syrigos, Vassilis L. Souliotis
Summary: The deregulated DNA damage response network is associated with the onset and progression of lung cancer. This study found that lung cancer patients have higher levels of endogenous DNA damage, which may be caused by oxidative stress and defective DNA repair mechanisms. The findings suggest that oxidative stress and DDR-related aberrations contribute to the accumulation of endogenous DNA damage in lung cancer patients.
Article
Biochemistry & Molecular Biology
Vladimir Baran, Jozef Pisko
Summary: The preimplantation period of embryogenesis plays a crucial role in mammalian development, and cellular abnormalities during this period are the main cause of fetal developmental disorders. Research has found that DNA damage induced before DNA synthesis can significantly affect the preimplantation development of the embryo, and the extent of DNA damage is related to this developmental ability. Although one-cell embryos can correct the first cleavage cycle, a segregation disorder of condensed chromatin after the first cleavage can result in the formation of micronuclei.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Elizabeth A. Pollina, Daniel T. Gilliam, Andrew T. Landau, Cindy Lin, Naomi Pajarillo, Christopher P. Davis, David A. Harmin, Ee-Lynn Yap, Ian R. Vogel, Eric C. Griffith, M. Aurel Nagy, Emi Ling, Erin E. Duffy, Bernardo L. Sabatini, Charles J. Weitz, Michael E. Greenberg
Summary: Neuronal activity poses a risk to genome stability, but neurons have a specialized DNA repair mechanism that protects against damage caused by activity. This mechanism involves a specific complex called NPAS4-NuA4, which repairs DNA double-strand breaks and protects regulatory elements from somatic mutations. Disruption of this complex can lead to neurodevelopmental disorders, neurodegeneration, and reduced lifespan.
Article
Biochemistry & Molecular Biology
Mateusz Kciuk, Adrianna Gieleci, Somdutt Mujwar, Mariusz Mojzych, Renata Kontek
Summary: The cyclin-dependent kinase (CDK) family plays a critical role in regulating transcription and cell-cycle progression. Recent studies have revealed their involvement in DNA damage response (DDR) and repair, impacting the fidelity of cell division and maintenance of genomic integrity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Ayuna Hattori, Emi Takamatsu-Ichihara, Yoshiki Yamamoto, Shuhei Fujita, Kazutsune Yamagata, Takuo Katsumoto, Yukino Machida, Haruka Shinohara, Ryo Murakami, Issay Kitabayashi
Summary: The chromatin-associated AAA+ ATPases Tip48 and Tip49 are crucial for various nuclear events and frequently overexpressed in human cancers. Loss of Tip49 triggers p53-dependent apoptosis and inhibits leukemia development. The compound DS-4950, which inhibits the ATPase activity of Tip48/49, effectively reduces tumor burden and improves survival in leukemia models. These findings suggest that Tip48/49 ATPases are functionally necessary and therapeutically targetable for the treatment of human cancers.
Article
Genetics & Heredity
Marit A. E. van Bueren, Aniek Janssen
Summary: Eukaryotic nuclei rely on multiple repair pathways to accurately repair DNA damage, particularly in chromatin domains enriched for repetitive DNA sequences. Tailored repair mechanisms are necessary to maintain genome stability in these domains.
