Review
Pharmacology & Pharmacy
Edward J. Calabrese
Summary: This paper provides a detailed assessment of hormetic dose responses in adipose-derived stem cells (ADSCs) of animal models and humans, showing that hormetic dose responses are commonly reported for ADSCs and may have a determinant role in potential clinical applications.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Hyun Kyoung Kang, Dong Jin Kim, Min Soo Kim, Da-Hyun Kim, Jin Young Lee, Eun-Ah Sung, Madina Sarsenova, Seong Chae Park, Byung Hee Hong, Kyung-Sun Kang
Summary: Graphene quantum dots (GQDs) can promote the efficient differentiation of stem cells into hepatocytes by activating insulin-like growth factor 1 receptor (IGF1R) signaling through incorporated calcium ions. The treatment of stem cells with GQDs derived from coffee beans enhances the maturation into hepatocytes and reduces differentiation towards cholangiocytes, resulting in a large number of functional hepatocyte-like cells. Therefore, GQDs could be a cost-effective alternative to IGF1 as a growth factor and differentiation factor.
Article
Biochemistry & Molecular Biology
Yinpeng Jin, Rongfeng Shi, Tangkai Qi, Qiang Li, Cong Chen, Shane Gao, Fengjuan Gao, Danjing Yang, Guangxi Sun, Jianqing Xu, Qingchun Fu, Jun Xu, Xiaoyan Zhang
Summary: Hepatocyte transplantation is hindered by limited resources, but mesenchymal stem cells (MSCs) can differentiate into hepatocyte-like cells (HLCs) and provide some hepatocyte functions. In this study, human adipose-derived stem cells (hADSCs) were found to have stronger hepatic differentiation ability compared to umbilical cord MSCs (hUCMSCs). The use of hADSCs-HLC or a combination of hADSCs and hADSCs-HLC had a better curative effect in treating acute liver failure, leading to hepatocyte regeneration, liver function recovery, reduced systemic inflammatory reaction, and improved survival rate.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell & Tissue Engineering
Yang Zhang, Yanqi Zhong, Weifang Liu, Fanghui Zheng, Yin Zhao, Li Zou, Xiaoxia Liu
Summary: The study revealed the importance of PFKFB3-mediated glycolysis in endothelial differentiation and angiogenesis of PMSCs, showing that PMSCs have a strong potential for endothelial differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Gastroenterology & Hepatology
Patrick Nell, Kathrin Kattler, David Feuerborn, Birte Hellwig, Adrian Rieck, Abdulrahman Salhab, Konstantin Lepikhov, Gilles Gasparoni, Antonia Thomitzek, Katharina Belgasmi, Nils Bluethgen, Markus Morkel, Barbara Kueppers-Munther, Patricio Godoy, David C. Hay, Cristina Cadenas, Rosemarie Marchan, Nachiket Vartak, Karolina Edlund, Joerg Rahnenfuehrer, Joern Walter, Jan G. Hengstler
Summary: Targeted modification of the FXR gene regulatory network improves differentiation of stem cell-derived hepatocytes by suppressing intestinal traits and inducing hepatocyte features, bringing them closer to hepatocytes derived from human livers.
JOURNAL OF HEPATOLOGY
(2022)
Article
Cell & Tissue Engineering
Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Summary: Andrographolide (AP) has been shown to promote proliferation, osteogenic differentiation, and bone formation of placenta-derived mesenchymal stem cells. It may be an effective novel agent for improving placenta-derived MSCs and stem cell-based therapy for bone regeneration. The compound enhances Wnt/beta-catenin signaling and osteoblast-specific gene expressions, promoting bone formation and increasing osteocalcin levels.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eleanor Luce, Clara Steichen, Soumeya Abed, Anne Weber, Philippe Leboulch, Leila Maouche-Chretien, Anne Dubart-Kupperschmitt
Summary: The study demonstrates that siPSCs can differentiate into liver cells and self-organize into 3D structures, facilitating research on liver development and the development of co-culture systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yanina Bogliotti, Mark Vander Roest, Aras N. Mattis, Robert G. Gish, Gary Peltz, Robin Anwyl, Salah Kivlighn, Eric R. Schuur
Summary: Liver disease is a major cause of global mortality, with late-stage liver disease being characterized by hepatocyte injury, inflammation, and aberrant tissue healing. Treatment options for liver disease are limited, but cell replacement therapy using hepatocyte-like cells shows promise as a safe and effective treatment option.
Review
Cell Biology
Ashraf Al Madhoun, Sardar Sindhu, Dania Haddad, Maher Atari, Rasheed Ahmad, Fahd Al-Mulla
Summary: Dental pulp stem cells have promising characteristics, but genotypic and phenotypic heterogeneities may impact their therapeutic potentials. Studies suggest that their heterogeneity arises from an interplay between intrinsic and extrinsic factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Faiza Farhan, Manjari Trivedi, Priscilla Di Wu, Wei Cui
Summary: This study found that HLCs cultured with collagen showed increased albumin and alpha-1 anti-trypsin expression, reduced AFP, and higher urea secretion compared to HLCs cultured with Matrigel. However, collagen-cultured HLCs exhibited lower CYP3A4 activity and glycogen storage than Matrigel-cultured HLCs. The functional differences in HLCs between collagen and Matrigel cultures resemble hepatic zonation in the liver lobules.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cadenas-Martin Marta, Moratilla Adrian, Fernandez-Delgado Jorge, Arnalich-Montiel Francisco, Maria P. De Miguel
Summary: Corneal disease affects millions worldwide and standard treatment involves transplantation, but there is a shortage. Lamellar endothelial keratoplasty and directed differentiation of adult stem cells show promise in addressing the issue. Efforts are ongoing to find new sources of corneal endothelial cells for transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Nicole Min Qian Pek, Kevin J. Liu, Massimo Nichane, Lay Teng Ang
Summary: Hepatocytes in the liver are high-performance engines of various metabolic functions and versatile responders to liver injury. Understanding the mechanisms of liver regeneration, particularly the mobilization of liver cells, is crucial for liver maintenance and repair. Controversies persist regarding the existence and characteristics of hepatic stem cells, but insights into hepatocyte regeneration may inform in vitro studies for liver regeneration and hepatocyte generation from pluripotent stem cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyeonji Kim, Keonhyeok Park, Jung-Min Yon, Sung Won Kim, Soo Young Lee, Iljoo Jeong, Jinah Jang, Seungchul Lee, Dong-Woo Cho
Summary: This study successfully predicted the multipotency rate of human nasal turbinate stem cells (hNTSCs) using a cellular morphology-based prediction method, providing a new approach for quality control in clinical cell therapies.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Luminita Labusca, Camelia Danceanu, Anca Emanuela Minuti, Dumitru-Daniel Herea, Adrian Ghemes, Cristian Rotarescu, Oana Dragos-Pinzaru, Mihai Tibu, Grigoras Marian, Horia Chiriac, Nicoleta Lupu
Summary: Magnetic nanomaterials have a growing impact in the field of biology and medicine due to their versatility in drug delivery, cell targeting, and imaging. This study investigates the use of uncoated nickel nanowires as a mechanically-responsive substrate for inducing osteogenic differentiation of adipose derived-mesenchymal cells (ASCs) through magneto-mechanical stimulation. Preliminary results show a significant increase in osteogenic differentiation of ASCs exposed to a specific magnetic field, while adipogenic differentiation remains unchanged.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Summary: GCM1 is a critical regulator of human placenta development, playing a key role in the differentiation and function of EVT and ST. Knockdown of GCM1 hinders TS cell differentiation and impacts their functions in both ST and EVT pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
