Extracellular matrix modulates the spatial hepatic features in hepatocyte-like cells derived from human embryonic stem cells

Global burden of liver disease: 2023 update

(2023) Harshad Devarbhavi et al.   JOURNAL OF HEPATOLOGY

Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites

(2021) Annie S P Yang et al.   EMBO JOURNAL

Liver Zonation – Revisiting Old Questions With New Technologies

(2021) Rory P. Cunningham et al.   Frontiers in Physiology

Development of a tunable method to generate various three-dimensional microstructures by replenishing macromolecules such as extracellular matrix components and polysaccharides

(2020) Fumiya Tao et al.   Scientific Reports

Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

(2020) Ruihua Ma et al.   eLife

Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level

(2020) Xin Wang et al.   CELL RESEARCH

Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

(2020) Xiugong Gao et al.   Stem Cell Research & Therapy

In Search of Zonation Markers to Identify Liver Functional Disorders

(2020) Qiuyuan Yang et al.   Oxidative Medicine and Cellular Longevity

Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome

(2020) Jin-Ju Kim et al.   EBioMedicine

Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury

(2019) M. Teresa Donato et al.   DIFFERENTIATION

The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

(2019) Natalia Sánchez-Romero et al.   DIFFERENTIATION

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism

(2019) Haixing Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

(2018) Chen Chen et al.   GASTROENTEROLOGY

Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs)

(2018) Maria Jaramillo et al.   Journal of Tissue Engineering and Regenerative Medicine

Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages

(2018) Shun Shibata et al.   Cell Reports

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Metabolic zonation of the liver: The oxygen gradient revisited

(2017) Thomas Kietzmann   Redox Biology

Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution

(2016) Andrea Baiocchini et al.   PLoS One

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

(2015) Melissa Baxter et al.   JOURNAL OF HEPATOLOGY

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

(2015) Jason S. L. Yu et al.   Nature Communications

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

(2015) Kate Cameron et al.   Stem Cell Reports

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

(2015) Shengyong Ng et al.   Stem Cell Reports

Competency of different cell models to predict human hepatotoxic drugs

(2014) M José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

(2013) Hsueh-Liang Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides andde novosynthesized fatty acids in HepG2 cells

(2012) Haja R. Wurie et al.   FEBS Journal

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

(2012) Jenson Qi et al.   JOURNAL OF LIPID RESEARCH

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism

(2009) Zoé D. Burke et al.   GASTROENTEROLOGY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

(2008) Kenneth S. Zaret   NATURE REVIEWS GENETICS

Role of cytochrome P450 in drug interactions

(2008) Zakia Bibi   Nutrition & Metabolism

Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo

(2008) David C. Hay et al.   STEM CELLS