The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

(2012) Y. J. Park et al.   DIABETOLOGIA

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets

(2011) K. Aston-Mourney et al.   DIABETOLOGIA

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

(2011) S. L. Subramanian et al.   DIABETOLOGIA

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

(2011) Gunilla T. Westermark et al.   TRANSPLANTATION

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Long-Term Metabolic and Hormonal Effects of Exenatide on Islet Transplant Recipients with Allograft Dysfunction

(2010) Raquel N. Faradji et al.   CELL TRANSPLANTATION

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

(2010) R. Fan et al.   DIABETES OBESITY & METABOLISM

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

(2009) M J Riedel et al.   GENE THERAPY

Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists

(2009) K. B. Hansen et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

(2008) L. Marzban et al.   DIABETES

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

(2008) J. Udayasankar et al.   DIABETOLOGIA

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

(2008) S. Casas et al.   DIABETOLOGIA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets

(2008) Gunilla T. Westermark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA