SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

(2014) Birgitte Holst et al.   PLOS BIOLOGY

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

(2014) Mian Cao et al.   PLOS BIOLOGY

Age-Dependent Labeling and Imaging of Insulin Secretory Granules

(2013) A. Ivanova et al.   DIABETES

Are we overestimating the loss of beta cells in type 2 diabetes?

(2013) Lorella Marselli et al.   DIABETOLOGIA

Lysosomal sorting receptors are essential for secretory granule biogenesis inTetrahymena

(2013) Joseph S. Briguglio et al.   JOURNAL OF CELL BIOLOGY

SORCS1 contributes to the development of renal disease in rats and humans

(2013) Jozef Lazar et al.   PHYSIOLOGICAL GENOMICS

The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer’s Disease in Chinese Han Population

(2013) Wei Xu et al.   PLoS One

Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3

(2013) Daniel W. Sirkis et al.   PLoS Genetics

Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection

(2012) Pierre-Julien Sloves et al.   Cell Host & Microbe

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

(2012) Alanna Strong et al.   JOURNAL OF CLINICAL INVESTIGATION

A shortcut to the lysosome: The mannose-6-phosphate-independent pathway

(2012) Maria Francisca Coutinho et al.   MOLECULAR GENETICS AND METABOLISM

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese

(2012) Yanqin HE et al.   Psychogeriatrics

Sortilin: a receptor to regulate neuronal viability and function

(2012) Anders Nykjaer et al.   TRENDS IN NEUROSCIENCES

Sorting Out Sortilin

(2011) Alan R. Tall et al.   CIRCULATION RESEARCH

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry

(2011) Kevin W. Stewart et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet β-cells

(2010) Arthur T. Suckow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

(2010) Christiane Reitz et al.   ANNALS OF NEUROLOGY

Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export

(2010) Mads Kjolby et al.   Cell Metabolism

Sortilins: new players in lipoprotein metabolism

(2010) Thomas E Willnow et al.   CURRENT OPINION IN LIPIDOLOGY

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway

(2010) Cédric S. Asensio et al.   JOURNAL OF CELL BIOLOGY

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose

(2009) A. D. Paterson et al.   DIABETES

Genetic basis of β-cell dysfunction in man

(2009) L. Groop et al.   DIABETES OBESITY & METABOLISM

Impaired dense core vesicle maturation inCaenorhabditis elegansmutants lacking Rab2

(2009) Stacey L. Edwards et al.   JOURNAL OF CELL BIOLOGY

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sortilin mediates the lysosomal targeting of cathepsins D and H

(2008) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation

(2008) T. Giordano et al.   DIABETOLOGIA

Emerging roles for centromeres in meiosis I chromosome segregation

(2008) Gloria A. Brar et al.   NATURE REVIEWS GENETICS