Cooperation between cAMP signalling and sulfonylurea in insulin secretion

 -Cell-Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing Acute-Phase Insulin Secretion

(2013) K. A. Kaihara et al.   DIABETES

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome

(2013) Alan K. L. Kai et al.   FASEB JOURNAL

KATP channels and islet hormone secretion: new insights and controversies

(2013) Frances M. Ashcroft et al.   Nature Reviews Endocrinology

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A

(2013) T. Takahashi et al.   Science Signaling

Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea

(2012) S. Seino   DIABETOLOGIA

MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway

(2012) Flora Brozzi et al.   MOLECULAR BIOLOGY OF THE CELL

Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion

(2011) Woo-Jin Song et al.   Cell Metabolism

Direct Activation of Epac by Sulfonylurea Is Isoform Selective

(2011) Katie J. Herbst et al.   CHEMISTRY & BIOLOGY

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation

(2011) Daisuke Yabe et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications

(2010) Michael A. Nauck   AMERICAN JOURNAL OF MEDICINE

Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis

(2010) Takao Yasuda et al.   Cell Metabolism

Epac2-dependent mobilization of intracellular Ca2+by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice

(2010) Igor Dzhura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sulfonylurea action re-revisited

(2010) Susumu Seino et al.   Journal of Diabetes Investigation

GIP and GLP-1, the two incretin hormones: Similarities and differences

(2010) Yutaka Seino et al.   Journal of Diabetes Investigation

Unraveling the Science of Incretin Biology

(2009) Michael A. Nauck   AMERICAN JOURNAL OF MEDICINE

Roles of cAMP signalling in insulin granule exocytosis

(2009) S. Seino et al.   DIABETES OBESITY & METABOLISM

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

(2009) C.-L. Zhang et al.   SCIENCE

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE