Metabolic stress, IAPP and islet amyloid

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

(2012) Y. J. Park et al.   DIABETOLOGIA

Accumulation of Intrahepatic Islet Amyloid in a Nonhuman Primate Transplant Model

(2012) Chengyang Liu et al.   ENDOCRINOLOGY

Translational Control of Glucose-Induced Islet Amyloid Polypeptide Production in Pancreatic Islets

(2012) Cristina Alarcon et al.   ENDOCRINOLOGY

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets

(2011) K. Aston-Mourney et al.   DIABETOLOGIA

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

(2011) S. L. Subramanian et al.   DIABETOLOGIA

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling

(2011) J Bailey et al.   PHYSICAL BIOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Cholesterol in β-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes

(2010) Liam R. Brunham et al.   Current Diabetes Reports

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

(2010) G. J. S. Cooper et al.   DIABETOLOGIA

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Proinsulin Processing is a Characteristic of Transplanted Islets

(2009) A. M. Klimek et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Amyloid inhibitors enhance survival of cultured human islets

(2009) Kathryn J. Potter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death†

(2008) Fanling Meng et al.   BIOCHEMISTRY

Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

(2008) L. Marzban et al.   DIABETES

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets

(2008) Gunilla T. Westermark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

(2008) Jefferson D. Knight et al.   PROTEIN SCIENCE