Review
Nutrition & Dietetics
Heitor O. Santos, Theresa L. May, Allain A. Bueno
Summary: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are important in preventing and managing cardiometabolic diseases associated with chronic inflammation. The effects of n-3 PUFA supplements in reducing cardiovascular risks are uncertain, and their use can result in polypharmacy. Sardines are a cost-effective source of n-3 PUFA and other cardioprotective nutrients, but more research is needed to translate this recommendation into clinical practice. Sardines contain minerals and nutrients that modulate inflammation and oxidative stress observed in cardiovascular disease, with calcium, potassium, and magnesium being the most clinically beneficial. Randomized clinical trials are needed to further investigate the benefits of sardine consumption.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Saranporn Wongpattananukul, Uarna Nungarlee, Arnakorn Ruangprach, Suwaibah Sulong, Promluck Sanporkha, Sirichai Adisakwattana, Sathaporn Ngamukote
Summary: The use of Sacha inchi oil (IPO) as a substitute for animal fat in meat products can improve the nutritional properties by reducing saturated fat content and omega-6/omega-3 ratio while increasing omega-3 fatty acid content. Moreover, it can enhance the emulsion stability and texture properties of sausages. However, the addition of higher amounts of IPO may increase TBARS value during refrigerated storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Neurosciences
Welayah Ali AlAmmar, Fatima Hassan Albeesh, Layla Makki Ibrahim, Yasmin Yussuf Algindan, Lamya Zohair Yamani, Rabie Yousif Khattab
Summary: This study systematically reviewed literature on the effects of omega-3 fatty acids in adults with multiple sclerosis (MS), finding that fish oil supplementation and omega-3 fatty acids can improve the quality of life for MS patients.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Alexis Ceecee Britten-Jones, Jordan T. Kamel, Leslie J. Roberts, Sabine Braat, Jennifer P. Craig, Richard J. MacIsaac, Laura E. Downie
Summary: In this study, it was found that long-chain omega-3 fatty acid supplements have neuroregenerative effects on peripheral nerves in type 1 diabetes patients, indicating a potential role in modulating nerve health.
Article
Biology
Mariely Mendes Furtado, Joana erica Lima Rocha, Ana Victoria da Silva Mendes, Renato Sampaio Mello Neto, Ana Karolinne da Silva Brito, Jose Otavio Carvalho Sena de Almeida, Emerson Iuri Rodrigues Queiroz, Jose Vinicius de Sousa Franca, Ana Lina de Carvalho Cunha Sales, Andreanne Gomes Vasconcelos, Wanessa Felix Cabral, Luana de Oliveira Lopes, Iolanda Souza do Carmo, Selma Aparecida Souza Kueckelhaus, Jose Roberto de Souza de Almeida Leite, Adriana Maria Viana Nunes, Marcia dos Santos Rizzo, Antonia Maria das Gracas Lopes Cito, Ana Karina Marques Fortes Lustosa, Massimo Lucarini, Alessandra Durazzo, Maria do Carmo de Carvalho e Martins, Daniel Dias Rufino Arcanjo
Summary: Processed and ultraprocessed foods increase the risk of obesity, diabetes, and atherosclerosis. This study investigated the effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on liver function, lipid profile, and cardiovascular health in hypercholesterolemic rats. The results showed that omega-3 PUFA supplementation improved liver function, preserved heart and aortic morphology, and increased vasodilator responsiveness, suggesting its potential therapeutic use in reducing atherosclerosis-related morbidity and mortality.
Article
Agronomy
Supriyanto Supriyanto, Zulhamsyah Imran, Rhomi Ardiansyah, Brian Auliyai, Aditya Pratama, Faustinus Kadha
Summary: Sacha Inchi, a Peruvian seed with high levels of unsaturated fatty acids, has been studied under different cultivation conditions in order to determine its adaptability and effects on seed production and oil quality. The results showed that seed productivity was highest in open area cultivation, while oil yield was highest in mixed cultures. The content of Omega-3 was highest in the agroforestry condition, while Omega-6 and Omega-9 were highest in the open area.
Review
Nutrition & Dietetics
Linlin Huang, Fanjie Zhang, Ping Xu, Yijie Zhou, Yijun Liu, Hongdie Zhang, Xiaozhen Tan, Xinxu Ge, Yong Xu, Man Guo, Yang Long
Summary: Current guidelines recommend regular consumption of fat-rich fish to obtain sufficient omega-3 polyunsaturated fatty acids for preventing cardiovascular events. However, the cardiovascular benefits of omega-3 polyunsaturated fatty acids in patients with diabetes are uncertain. This meta-analysis of randomized controlled trials found that omega-3 fatty acid supplementation reduces cardiovascular disease risk in patients with diabetes, with eicosapentaenoic acid showing a significant effect. Further well-designed trials are needed to evaluate safety and effects on atrial fibrillation.
ADVANCES IN NUTRITION
(2023)
Article
Sport Sciences
Cody A. C. Lust, Jessie L. Burns, Margaret T. Jones, Stephen B. Smith, Seong Ho Choi, Michele Krk, David A. Gable, Jonathan M. Oliver, David W. L. Ma
Summary: This study investigated the dose-response effect of docosahexaenoic acid (DHA) supplementation in American-style football (ASF) players throughout a competitive season. The findings showed that supplementing with DHA significantly increased DHA levels in red blood cells (RBC) and rapidly achieved the desired Omega-3 Index (O3I) in athletes within 8 weeks.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Nutrition & Dietetics
Annette L. West, Elizabeth A. Miles, Lihua Han, Karen A. Lillycrop, Johnathan A. Napier, Philip C. Calder, Graham C. Burdge
Summary: The study showed that transgenic Camelina sativa seed oil and fish oil are both effective in increasing the levels of eicosapentaenoic acid and docosahexaenoic acid in white blood cells. The alteration of T cell transcriptome induced by mitogens varied between the two oils, with changes related to cell proliferation and immune function. The incorporation of these fatty acids into immune cells was comparable between the two oils, suggesting potential benefits for immune function.
Review
Nutrition & Dietetics
Andrew Elagizi, Carl J. Lavie, Evan O'Keefe, Keri Marshall, James H. O'Keefe, Richard V. Milani
Summary: Interest in the potential cardiovascular benefits of omega-3 polyunsaturated fatty acids (omega-3) began in the 1940s, but there has been controversy due to conflicting results among studies and meta-analyses. Recent large, randomized trials showed discordant findings, with one using a higher dose of omega-3 showing a significant reduction in cardiovascular events. The conflicting results in clinical trials may be due to inadequate dosing of omega-3 and aggressive treatment with other effective therapies.
Review
Nutrition & Dietetics
Daniel Rodriguez, Carl J. Lavie, Andrew Elagizi, Richard V. Milani
Summary: This paper discusses the importance of using omega-3 fatty acids in cardiovascular diseases and summarizes related research and recommendations.
Article
Nutrition & Dietetics
Hong Jiang, Lina Wang, Duolao Wang, Ni Yan, Chao Li, Min Wu, Fan Wang, Baibing Mi, Fangyao Chen, Wanru Jia, Xi Liu, Jiaxin Lv, Yan Liu, Jing Lin, Le Ma
Summary: This study conducted a meta-analysis to summarize evidence from prospective studies on the associations between omega-3 PUFA biomarkers and the risk of developing chronic diseases. The results showed that higher concentrations of marine-derived omega-3 PUFA biomarkers were associated with a significantly reduced risk of cardiovascular diseases, coronary heart disease, and total mortality. Levels of ALA were inversely associated with a lower risk of type 2 diabetes.
CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Liv Nesse Hande, Christian Kjellmo, Kristin Pettersen, Stefan Ljunggren, Helen Karlsson, Karin Cederbrant, Maritha Marcusson-Stahl, Anders Hovland, Knut Tore Lappegard
Summary: High-dose n-3 PUFAs supplements reduce atherogenic lipoproteins in FH subjects without affecting HDL-C function.
Review
Food Science & Technology
Soheila Abachi, Genevieve Pilon, Andre Marette, Laurent Bazinet, Lucie Beaulieu
Summary: This article focuses on recent studies on hypoglycemic, lipid-lowering, cholesterol-lowering, and anti-obesity fish peptides. The aim is to provide more knowledge for the design and discovery of anti-MetS compounds by comparing different extraction, isolation, and purification methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Jie Zhu, Peng-Cheng Xun, Marissa Kolencik, Ke-Feng Yang, Alyce D. Fly, Ka Kahe
Summary: Studies have suggested that the combined supplementation of B vitamins and omega-3 PUFAs may have additional benefits for preventing cardiovascular disease. However, the overall findings are inconsistent and inconclusive, and more well-designed trials are needed to draw firm conclusions.
Article
Hematology
K. Fixter, D. J. Rabbolini, B. Valecha, M. -C. Morel-Kopp, S. Gabrielli, Q. Chen, W. S. Stevenson, C. M. Ward
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2018)
Article
Hematology
S. J. Mundell, D. Rabbolini, S. Gabrielli, Q. Chen, R. Aungraheeta, J. L. Hutchinson, T. Kilo, J. Mackay, C. M. Ward, W. Stevenson, M. -C. Morel-Kopp
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Cell Biology
David J. Rabbolini, Yenna Chun, Maya Latimer, Shinji Kunishima, Kathleen Fixter, Bhavia Valecha, Peter Tan, Lee Ping Chew, Benjamin T. Kile, Rachel Burt, Kottayam Radhakrishnan, Robert Bird, Paul Ockelford, Sara Gabrielli, Qiang Chen, William S. Stevenson, Christopher M. Ward, Marie-Christine Morel-Kopp
Letter
Medicine, General & Internal
Shalini Balendran, Alexander Harrison, Marie-Christine Morel-Kopp, Christopher Ward, Cecily Forsyth
INTERNAL MEDICINE JOURNAL
(2018)
Article
Medicine, General & Internal
Joanne Joseph, David Rabbolini, Anoop K. Enjeti, Emmanuel Favaloro, Marie-Christine Kopp, Simon McRae, Leonardo Pasalic, Chee Wee Tan, Christopher M. Ward, Beng H. Chong
MEDICAL JOURNAL OF AUSTRALIA
(2019)
Article
Cardiac & Cardiovascular Systems
Geoffrey H. Tofler, Marie-Christine Morel-Kopp, Monica Spinaze, Jill Dent, Christopher Ward, Sharon McKinley, Anastasia S. Mihailidou, Jennifer Havyatt, Victoria Whitfield, Roger Bartrop, Judith Fethney, Holly G. Prigerson, Thomas Buckley
AMERICAN HEART JOURNAL
(2020)
Article
Hematology
Paolo Gresele, Sara Orsini, Patrizia Noris, Emanuela Falcinelli, Marie Christine Alessi, Loredana Bury, Munira Borhany, Cristina Santoro, Ana C. Glembotsky, Ana Rosa Cid, Alberto Tosetto, Erica De Candia, Pierre Fontana, Giuseppe Guglielmini, Alessandro Pecci, Federica Melazzini, Celine Falaise, Alessandra Casonato, Gianmarco Podda, Meganathan Kannan, Kerstin Jurk, Teresa Sevivas, Giancarlo Castaman, Elvira Grandone, Mathieu Fiore, Pamela Zuniga, Yvonne Henskens, Koji Miyazaki, Arnaud Dupuis, Catherine Hayward, Carlo Zaninetti, Madiha Abid, Grazia Ferrara, Maria Gabriella Mazzucconi, Giuseppe Tagariello, Paula James, Fabrizio Fabris, Alexandra Russo, Nuria Bermejo, Mariasanta Napolitano, Jennifer Curnow, Gkalea Vasiliki, Barbara Zieger, Marian Fedor, Meera Chitlur, Michele Lambert, Luca Barcella, Benilde Cosmi, Paola Giordano, Claudia Porri, Ibrahim Eker, Marie-Christine Morel-Kopp, Hans Deckmyn, Andrew L. Frelinger, Paul Harrison, Diego Mezzano, Andrew D. Mumford
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Pathology
David Rabbolini, David Connor, Marie-Christine Morel-Kopp, Dea Donikian, Mayuko Kondo, Walter Chen, Marie-Christine Alessi, William Stevenson, Vivien Chen, Joanne Joseph, Timothy Brighton, Christopher Ward
Review
Cell Biology
Maggie L. Kalev-Zylinska, Marie-Christine Morel-Kopp, Christopher M. Ward, James Hearn, Justin R. Hamilton, Anna Y. Bogdanova
Summary: Ionotropic glutamate receptors, including AMPAR, KAR, and NMDAR, play distinct roles in platelet function, with AMPAR and KAR amplifying platelet function and thrombus formation, and the contribution of NMDAR being less well defined.
Article
Cell Biology
David Rabbolini, Hai Po Helena Liang, Marie-Christine Morel-Kopp, David Connor, Shane Whittaker, Scott Dunkley, Dea Donikian, Mayuko Kondo, Walter Chen, William S. Stevenson, Heather Campbell, Joanne Joseph, Christopher Ward, Timothy Brighton, Vivien M. Chen
Summary: Variants of the DIAPH1 gene have been reported to cause inherited macrothrombocytopenia, early-onset progressive sensorineural hearing loss, and mild asymptomatic neutropenia, along with alterations in procoagulant platelet formation and possible dental anomalies.
Article
Cell Biology
David Connor, David Rabbolini, Marie-Christine Morel-Kopp, Kate Fixter, Dea Donikian, Mayuku Kondo, Onki Chan, Susan Jarvis, Walter Chen, Timothy Brighton, Vivien Chen, Christopher Ward, Joanne Joseph
Summary: This study examined the feasibility of using platelet forward scatter (FSC) measurements to assess platelet size and its potential as an alternative to mean platelet diameter (MPD) or mean platelet volume (MPV). The results showed that platelet FSC correlated significantly with MPD and MPV, and could be used as an alternative measurement in cases where MPV is not available, such as macrothrombocytopenia.
Article
Biochemistry & Molecular Biology
Young Eun Park, Rushi Penumarthy, Paul P. Sun, Caroline Y. Kang, Marie-Christine Morel-Kopp, Jonathan Downing, Taryn N. Green, Tracey Immanuel, Christopher M. Ward, Deborah Young, Matthew J. During, P. Alan Barber, Maggie L. Kalev-Zylinska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Hematology
Catherine Tang, David J. Rabbolini, Marie-Christine Morel-Kopp, David E. Connor, Philip Crispin, Christopher M. Ward, William S. Stevenson
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Geriatrics & Gerontology
Tu Ngoc Nguyen, Marie-Christine Morel-Kopp, Dominic Pepperell, Robert Graham Cumming, Sarah Nicole Hilmer, Christopher Morice Ward
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2017)
Article
Hematology
Tania Kamal, Taryn N. Green, James Hearn, Emma C. Josefsson, Marie-Christine Morel-Kopp, Christopher M. Ward, Matthew J. During, Maggie L. Kalev-Zylinska
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2018)
