Lymphatic vascular morphogenesis in development, physiology, and disease

Chemokine-Enhanced Chemotaxis of Lymphangioleiomyomatosis Cells with Mutations in the Tumor Suppressor TSC2 Gene

(2014) G. Pacheco-Rodriguez et al.   JOURNAL OF IMMUNOLOGY

GJC2 Missense Mutations Cause Human Lymphedema

(2010) Robert E. Ferrell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans

(2010) Audrey C. Au et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

(2010) Fei Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish

(2010) Ilse Geudens et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch Leads Lymphatics and Links Them to Blood Vessels

(2010) Shan Liao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Role of synectin in lymphatic development in zebrafish and frogs

(2010) K. Hermans et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis

(2010) Luqing Zhang et al.   CELL RESEARCH

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk

(2010) J. Bussmann et al.   DEVELOPMENT

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

(2010) E. J. Gordon et al.   DEVELOPMENT

Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes

(2010) Ruben Böhmer et al.   DEVELOPMENTAL CELL

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity

(2010) E. Gjini et al.   Disease Models & Mechanisms

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

(2010) P. Saharinen et al.   GENES & DEVELOPMENT

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming

(2010) A. Hansen et al.   GENES & DEVELOPMENT

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells

(2010) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tbx1 regulatesVegfr3and is required for lymphatic vessel development

(2010) Li Chen et al.   JOURNAL OF CELL BIOLOGY

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development

(2010) Fu-Jung Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphangioleiomyomatosis: A Disease Involving the Lymphatic System

(2010) Kuniaki Seyama et al.   Lymphatic Research and Biology

Lymphatic Dysfunction, Not Aplasia, Underlies Milroy Disease

(2010) Russell H. Mellor et al.   MICROCIRCULATION

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Lymphangioleiomyomatosis (LAM): Molecular insights lead to targeted therapies

(2010) Connie G. Glasgow et al.   RESPIRATORY MEDICINE

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology

Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus

(2010) Jaehyuk Yoo et al.   PLoS Pathogens

Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development-Brief Report

(2009) Gabriela D'Amico et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of lymphatic-blood vessel separation by endothelial Rac1

(2009) G. D'Amico et al.   DEVELOPMENT

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries

(2009) B. M. Hogan et al.   DEVELOPMENT

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

(2009) Carla Mouta-Bellum et al.   DEVELOPMENTAL DYNAMICS

COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction

(2009) Tomoko Yamazaki et al.   GENES TO CELLS

Novel missense mutations in theFOXC2gene alter transcriptional activity

(2009) M.A.M. van Steensel et al.   HUMAN MUTATION

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

(2009) Camilla Norrmén et al.   JOURNAL OF CELL BIOLOGY

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contractile Physiology of Lymphatics

(2009) David C. Zawieja   Lymphatic Research and Biology

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

(2009) Jane J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor lymphatics

(2009) Jonathan Sleeman et al.   SEMINARS IN CANCER BIOLOGY

Gorham's Disease

(2008) Kavita Radhakrishnan et al.   Annals of the New York Academy of Sciences

Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate

(2008) S. Lee et al.   BLOOD

Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees

(2008) Elisabetta Dejana et al.   CELL AND TISSUE RESEARCH

Phospholipase C 2 is necessary for separation of blood and lymphatic vasculature in mice

(2008) H. Ichise et al.   DEVELOPMENT

Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice

(2008) Michael Dellinger et al.   DEVELOPMENTAL BIOLOGY

Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos

(2008) Masanori Hirashima et al.   DEVELOPMENTAL BIOLOGY

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

(2008) N. C. Johnson et al.   GENES & DEVELOPMENT

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

(2008) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Secondary Lymphedema: Is it a Primary Disease?

(2008) S.G. Rockson   Lymphatic Research and Biology

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos

(2008) P. Haiko et al.   MOLECULAR AND CELLULAR BIOLOGY

Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

(2008) C. Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

Sox18 induces development of the lymphatic vasculature in mice

(2008) Mathias François et al.   NATURE

Adrenomedullin signaling is necessary for murine lymphatic vascular development

(2007) Kimberly L. Fritz-Six et al.   JOURNAL OF CLINICAL INVESTIGATION