Review
Cell Biology
Ramkumar Sambasivan, Benjamin Steventon
Summary: Recent studies have identified a population of bipotent neuromesodermal progenitors in the posterior region of the embryo, which possess the ability to generate spinal cord and paraxial mesoderm cells with a conserved regulatory network. By maintaining this flexible pool of multi-germ layer competent progenitors, the contribution to the elongating body axis can vary depending on relative growth rates in different regions, suggesting a potential role in driving alterations in the timing of embryo growth during evolution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jayshree Samanta, Hernandez Moura Silva, Juan J. Lafaille, James L. Salzer
Summary: Gli1-expressing neural stem cells in the subventricular zone of the adult mammalian brain have the ability to generate new oligodendrocytes for remyelination. Loss or inhibition of Gli1 enhances remyelination efficacy and may be a potential therapeutic strategy for demyelinating diseases like multiple sclerosis. Transcriptomic analysis of these neural stem cells provides valuable insights for identifying therapeutic targets to enhance remyelination.
Article
Cell Biology
Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He
Summary: Haploinsufficient mutation in the Arglu1 gene is associated with neural developmental disorders, including mental retardation and epilepsy, but the specific causes are not well understood. A study in mice found that Arglu1 deficiency leads to detachment of radial glial cells from the ventricular zone, causing ectopic localization of these cells and resulting in cell apoptosis and reduced neuron production, ultimately leading to microcephaly. This study provides mechanistic insights into the cortical malformations associated with Arglu1 haploinsufficient mutation in human patients.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Summary: Axial length is the primary determinant of eye size and is elongated in myopia. This study reveals that endoplasmic reticulum (ER) stress in the sclera and the PERK/ATF6 pathway are involved in the axial elongation during myopia development. The researchers also demonstrate that 4-PBA eye drops show promise as a drug for myopia suppression/treatment.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
John Isaac Murray, Elicia Preston, Jeremy P. Crawford, Jonathan D. Rumley, Prativa Amom, Breana D. Anderson, Priya Sivaramakrishnan, Shaili D. Patel, Barrington Alexander Bennett, Teddy D. Lavon, Erin Hsiao, Felicia Peng, Amanda L. Zacharias
Summary: Hox transcription factors play a crucial role in determining positional identity during animal development. The posterior Hox genes nob-1 and php-3 in the nematode C. elegans are regulated by several partially redundant transcriptional enhancers, including the anterior Hox gene ceh-13. These enhancers positively regulate nob-1 and php-3 expression, providing insight into the flexibility and complexity of Hox gene regulation. Moreover, defects in cell position and division patterns were observed in ceh-13 and nob-1;php-3 mutants, indicating that these factors also regulate lineage identity.
Review
Ophthalmology
Gary Hin-Fai Yam, Shaohua Pi, Yiqin Du, Jodhbir S. Mehta
Summary: The limbus is a crucial transition zone between the cornea and the conjunctiva and sclera. It plays important physiological roles in maintaining corneal health and the visual system. This article focuses on the posterior limbus and discusses its structural organization, cellular components, and potential cell therapy options for corneal disorders.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Plant Sciences
Hugo A. Mendez-Hernandez, Ana O. Quintana-Escobar, Miguel A. Uc-Chuc, Victor M. Loyola-Vargas
Summary: Auxin is essential for plant growth and development, and its homeostasis is maintained through processes like biosynthesis, transport, degradation, and conjugation. The GH3 family genes, identified in Coffea canephora, play a crucial role in somatic embryogenesis induction, showing a conserved structural topology for binding nucleotides and amino acids during SE. Understanding the function of CcGH3 genes provides insights for future exploration and genetic manipulation in C. canephora.
Review
Developmental Biology
Geneva Masak, Lance A. Davidson
Summary: The pharyngula stage of vertebrate development is characterized by the arrangement of ectoderm, mesoderm, and neural tissues from the anterior spinal cord to the posterior tail. This stage is preceded by gastrulation and neurulation, and it is through these processes that common structures are established. However, the mechanisms of formation for the anterior and posterior axial tissues are distinct and transition at different locations along the body axis.
CELLS & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Morgan Bennett, Kailyn Cleaves, Tarek Hewezi
Summary: DNA methylation and demethylation play crucial roles in regulating gene expression during plant growth and development, as well as in response to various phytohormone treatments. The study showed that genes involved in DNA methylation and demethylation have distinct spatial and temporal expression patterns in different plant tissues, and phytohormones can alter DNA methylation status in specific and redundant ways. Overall, the results suggest that DNA methylation and demethylation pathways act synergistically and antagonistically in various tissues and in response to phytohormone treatments, contributing to tissue differentiation and development through hormone-linked methylome regulation mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Brenda Anabel Lopez-Ruiz, Elsa H. Quezada-Rodriguez, Alma Pineyro-Nelson, Hugo Tovar, Berenice Garcia-Ponce, Maria de la Paz Sanchez, Elena R. Alvarez-Buylla, Adriana Garay-Arroyo
Summary: GWAS in 124 accessions identified 23 genes and five SNPs associated with primary root growth, shedding light on the genetic control mechanisms for root length in plants.
Article
Biology
Louis Scheurer, Rebecca R. Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, Hendrik Wildner
Summary: The study reveals the expression of two heavy chain immunoglobulin genes in neurons of the mouse brain and spinal cord, suggesting a previously unknown function of these neuronal proteins. Protein translation from these neuronal transcripts contains four Immunoglobulin domains, supported by immunohistochemical, Western blot, and in silico analyses.
LIFE SCIENCE ALLIANCE
(2021)
Article
Ecology
Michaela Schwaiger, Carmen Andrikou, Rohit Dnyansagar, Patricio Ferrer Murguia, Periklis Paganos, Danila Voronov, Bob Zimmermann, Tatiana Lebedeva, Heiko A. Schmidt, Grigory Genikhovich, Giovanna Benvenuto, Maria Ina Arnone, Ulrich Technau
Summary: Transcription factors play crucial roles in animal development, but their ancestral functions and evolutionary processes remain unclear. This study conducted gene screens in two early branching animals and discovered an ancestral gene regulatory feedback loop involved in axial patterning. It was also found that some mesodermal target genes in vertebrates were newly acquired.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Cell Biology
Anneline Pinson, Wieland B. Huttner
Summary: The evolutionary expansion of the neocortex is primarily due to an increased and prolonged proliferation of neural progenitor cells, with basal progenitors playing a key role in the generation of neurons. Recent studies have identified primate-specific and human-specific genes that promote increased proliferative capacity of cortical progenitors.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maxime Penisson, Mingyue Jin, Shengming Wang, Shinji Hirotsune, Fiona Francis, Richard Belvindrah
Summary: Human cerebral cortical malformations are associated with abnormalities in progenitor proliferation and neuronal migration. This study investigates the role of the LIS1 gene in the formation of bRG-like cells in the mouse embryonic brain. The results show that depletion of Lis1 prevents the amplification of bRG-like cells, leading to disruptions in progenitor number and position and contributing to lissencephaly pathogenesis.
HUMAN MOLECULAR GENETICS
(2022)
Article
Multidisciplinary Sciences
Hai-Bo Zhang, Xiao-Bao Ding, Jie Jin, Wen-Ping Guo, Qiao-Lei Yang, Peng-Cheng Chen, Heng Yao, Li Ruan, Yu-Tian Tao, Xin Chen
Summary: The house mouse is a valuable mammalian model for genetic research, offering insights into human diseases. To facilitate molecular mechanism studies in mice, researchers have developed the Mouse Interactome Database and a gene set linkage analysis web tool.
Article
Developmental Biology
Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E. Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew J. H. Smith, Valerie Wilson
BMC DEVELOPMENTAL BIOLOGY
(2015)
Letter
Cell Biology
Ivan Bedzhov, Monika Bialecka, Agata Zielinska, Joanna Kosalka, Francesco Antonica, Amelia J. Thompson, Kristian Franze, Magdalena Zernicka-Goetz
Article
Multidisciplinary Sciences
Matthias S. Roost, Roderick C. Slieker, Monika Bialecka, Liesbeth van Iperen, Maria M. Gomes Fernandes, Nannan He, H. Eka D. Suchiman, Karoly Szuhai, Francoise Carlotti, Eelco J. P. de Koning, Christine L. Mummery, Bastiaan T. Heijmans, Susana M. Chuva de Sousa Lopes
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Abel Vertesy, Wibowo Arindrarto, Matthias S. Roost, Bjorn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
NATURE COMMUNICATIONS
(2018)
Article
Biology
Richard H. Row, Amy Pegg, Brian A. Kinney, Gist H. Farr, Lisa Maves, Sally Lowell, Valerie Wilson, Benjamin L. Martin
Article
Cell & Tissue Engineering
Yongchun Zhang, Ying Yang, Ming Jiang, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susana M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que
Article
Developmental Biology
Filip J. Wymeersch, Stavroula Skylaki, Yali Huang, Julia A. Watson, Constantinos Economou, Carylyn Marek-Johnston, Simon R. Tomlinson, Valerie Wilson
Article
Biochemistry & Molecular Biology
Liam J. Ruske, Jochen Kursawe, Anestis Tsakiridis, Valerie Wilson, Alexander G. Fletcher, Richard A. Blythe, Linus J. Schumacher
Article
Biology
Andre Dias, Anastasiia Lozovska, Filip J. Wymeersch, Ana Novona, Anahi Binagui-Casas, Daniel Sobral, Gabriel G. Martins, Valerie Wilson, Moises Mallo
Review
Developmental Biology
Filip J. Wymeersch, Valerie Wilson, Anestis Tsakiridis
Summary: The generation of components of the embryonic body axis occurs in an anterior-to-posterior direction, driven by the production of various cell types from axial progenitors. Recent research focuses on the in vitro production of neuromesodermal progenitors and their potential implications in disease modeling and regenerative medicine.
Article
Biochemistry & Molecular Biology
Monika Bialecka, Joaquin Montilla-Rojo, Bernard A. J. Roelen, Ad J. Gillis, Leendert H. J. Looijenga, Daniela. C. F. Salvatori
Summary: This study compared tumour development in humanized immune system (HIS) mice and immunocompromised mice (NSG) after injection of cell lines, revealing that the HIS mouse model is comparable to, but not more sensitive than, the NSG immunodeficient model for studying the malignancy of stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Tatiana Solovieva, Valerie Wilson, Claudio D. Stern
Summary: The head-tail axis in birds and mammals develops from a growth zone in the tail-end called the node and tailbud, which contains cells that may be resident axial stem cells. Experiments have shown that the node can instruct self-renewing behavior in these stem cells, but further studies are needed to determine whether this behavior occurs at the population level or at the level of single cells.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. E. Wever, Christine L. L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Summary: Pluripotency is crucial for assessing stem cells, but there is a lack of standardization in the teratoma assay and ethical concerns about animal use. In vitro alternatives have been developed, but their use and malignancy testing remain limited. The teratoma assay is still preferred for safety assessment, highlighting the need for an in vitro assay for testing stem cell malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Maria Gomes Fernandes, Monika Bialecka, Daniela C. F. Salvatori, Susana M. Chuva de Sousa Lopes
MOLECULAR HUMAN REPRODUCTION
(2018)
Article
Cell Biology
Nannan He, Shujing J. Lim, Joana C. Moreira de Mello, Injerreau Navarro, Monika Bialecka, Daniela C. F. Salvatori, Lucette A. J. van der Westerlaken, Lygia V. Pereira, Susana M. Chuva de Sousa Lopes
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2017)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)