Neocortex expansion in development and evolution—from genes to progenitor cell biology

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

(2021) Maria Schörnig et al.   eLife

Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma

(2021) Kosuke Funato et al.   Cell Stem Cell

Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

(2021) Cleber A. Trujillo et al.   SCIENCE

An early cell shape transition drives evolutionary expansion of the human forebrain

(2021) Silvia Benito-Kwiecinski et al.   CELL

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma

(2020) Aparna Bhaduri et al.   Cell Stem Cell

Adult Human Glioblastomas Harbor Radial Glia-like Cells

(2020) Rong Wang et al.   Stem Cell Reports

Evolution of human brain-size associated NOTCH2NL genes proceeds towards reduced protein levels

(2020) Gerrald A Lodewijk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly

(2020) Nathalie Journiac et al.   Cell Reports

Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

(2020) Ayse Güven et al.   eLife

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain

(2020) Naoyuki Matsumoto et al.   eLife

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

(2020) Michael Heide et al.   SCIENCE

Lengthening Neurogenic Period during Neocortical Development Causes a Hallmark of Neocortex Expansion

(2020) Barbara K. Stepien et al.   CURRENT BIOLOGY

Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

(2020) Lei Xing et al.   NEURON

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Basal Progenitor Morphology and Neocortex Evolution

(2020) Nereo Kalebic et al.   TRENDS IN NEUROSCIENCES

Metabolic Regulation of Neocortical Expansion in Development and Evolution

(2020) Takashi Namba et al.   NEURON

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex

(2019) Simone Mayer et al.   NEURON

Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology

(2019) Nereo Kalebic et al.   Cell Stem Cell

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex

(2019) Milos Kostic et al.   Cell Reports

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

(2019) Maria C Marchetto et al.   eLife

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

(2019) Takashi Namba et al.   NEURON

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development

(2019) Ewoud R. E. Schmidt et al.   Scientific Reports

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

(2018) Ikuo K. Suzuki et al.   CELL

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates

(2018) Chad J. Donahue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

(2018) Marta Florio et al.   eLife

HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells

(2018) Stefan Zweifel et al.   Stem Cell Reports

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

(2018) Nereo Kalebic et al.   eLife

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

(2016) Tomoki Otani et al.   Cell Stem Cell

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses

(2016) Matteo Fossati et al.   NEURON

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

(2016) Tomasz J. Nowakowski et al.   NEURON

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

(2016) Xiang-Chun Ju et al.   eLife

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

(2016) Felipe Mora-Bermúdez et al.   eLife

A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification

(2016) M. Florio et al.   Science Advances

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Fixed single-cell transcriptomic characterization of human radial glial diversity

(2015) Elliot R Thomsen et al.   NATURE METHODS

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

(2015) Matthew B Johnson et al.   NATURE NEUROSCIENCE

The Outer Subventricular Zone and Primate-Specific Cortical Complexification

(2015) Colette Dehay et al.   NEURON

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Role of radial glial cells in cerebral cortex folding

(2014) Víctor Borrell et al.   CURRENT OPINION IN NEUROBIOLOGY

Integrin  v 3 and thyroid hormones promote expansion of progenitors in embryonic neocortex

(2014) D. Stenzel et al.   DEVELOPMENT

Neural progenitors, neurogenesis and the evolution of the neocortex

(2014) M. Florio et al.   DEVELOPMENT

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex

(2014) Jan H. Lui et al.   NATURE

Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability

(2014) Francesca Antonacci et al.   NATURE GENETICS

An Adaptive Threshold in Mammalian Neocortical Evolution

(2014) Eric Lewitus et al.   PLOS BIOLOGY

Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate

(2013) Ronny Stahl et al.   CELL

Multiplex Genetic Fate Mapping Reveals a Novel Route of Neocortical Neurogenesis, Which Is Altered in the Ts65Dn Mouse Model of Down Syndrome

(2013) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

(2013) Marion Betizeau et al.   NEURON

Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation

(2012) Cécile Charrier et al.   CELL

Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal

(2012) S. A. Fietz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors

(2011) Isabel Reillo et al.   CEREBRAL CORTEX

Oblique Radial Glial Divisions in the Developing Mouse Neocortex Induce Self-Renewing Progenitors outside the Germinal Zone That Resemble Primate Outer Subventricular Zone Progenitors

(2011) A. Shitamukai et al.   JOURNAL OF NEUROSCIENCE

A new subtype of progenitor cell in the mouse embryonic neocortex

(2011) Xiaoqun Wang et al.   NATURE NEUROSCIENCE

A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex

(2010) Isabel Reillo et al.   CEREBRAL CORTEX

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Diversity of Human Copy Number Variation and Multicopy Genes

(2010) Peter H. Sudmant et al.   SCIENCE

The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis

(2009) Sabrice Guerrier et al.   CELL

Evolution of the neocortex: a perspective from developmental biology

(2009) Pasko Rakic   NATURE REVIEWS NEUROSCIENCE

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities

(2008) Nicola Brunetti-Pierri et al.   NATURE GENETICS

Live Imaging at the Onset of Cortical Neurogenesis Reveals Differential Appearance of the Neuronal Phenotype in Apical versus Basal Progenitor Progeny

(2008) Alessio Attardo et al.   PLoS One