Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy

Long noncoding RNA Cfast regulates cardiac fibrosis

(2020) Feng Zhang et al.   Molecular Therapy-Nucleic Acids

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-AssociatedEndoplasmic Reticulum Membranes in vivo

(2019) Shengnan Wu et al.   CIRCULATION

The assembly of succinate dehydrogenase: a key enzyme in bioenergetics

(2019) Behrooz Moosavi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction

(2019) Feng Gao et al.   Nature Communications

SDHC-related deficiency of SDH complex activity promotes growth and metastasis of hepatocellular carcinoma via ROS/NFκB signaling

(2019) Jibin Li et al.   CANCER LETTERS

The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria

(2019) Rong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics of dilated cardiomyopathy: practical implications for heart failure management

(2019) Andrew N. Rosenbaum et al.   Nature Reviews Cardiology

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

(2018) Jimmy Zhang et al.   Cell Reports

Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats

(2018) Lixuan Zhan et al.   FASEB JOURNAL

Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging

(2018) Annunziata N. Crupi et al.   Aging-US

Regulation of Mitochondrial Electron Transport Chain Assembly

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Metabolic Characterization of Myocardial Infarction Using GC-MS-Based Tissue Metabolomics

(2017) Xingxing Wang et al.   International Heart Journal

Gene of the month: SDH

(2017) Alessandro Pietro Aldera et al.   JOURNAL OF CLINICAL PATHOLOGY

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension

(2017) Entai Hou et al.   Cell Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

(2016) Ayenachew Bezawork-Geleta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

(2016) Shangcheng Xu et al.   Nature Communications

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

(2016) Javier Prieto et al.   Nature Communications

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

(2015) Arezu Jahani-Asl et al.   HUMAN MOLECULAR GENETICS

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase

(2014) Un Na et al.   Cell Metabolism

SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration

(2014) Jonathan G. Van Vranken et al.   Cell Metabolism

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA

(2014) Ayenachew Bezawork-Geleta et al.   FASEB JOURNAL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel

(2013) Andrew P. Wojtovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

Unfavourable consequences of chronic cardiac HIF-1α stabilization

(2012) Marion Hölscher et al.   CARDIOVASCULAR RESEARCH

Argininosuccinate lyase deficiency

(2012) Sandesh C.S. Nagamani et al.   GENETICS IN MEDICINE

Mitochondria in cardiac hypertrophy and heart failure

(2012) Mariana G. Rosca et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Leukoencephalopathy with accumulated succinate is indicative of SDHAF1 related complex II deficiency

(2012) Andreas Ohlenbusch et al.   Orphanet Journal of Rare Diseases

Argininosuccinate lyase deficiency-Argininosuccinic aciduria and beyond

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A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

(2011) Zhihui Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase

(2010) Aviva Levitas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

A Genomic Screen for Yeast Mutants Defective in Selective Mitochondria Autophagy

(2009) Tomotake Kanki et al.   MOLECULAR BIOLOGY OF THE CELL

SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy

(2009) Daniele Ghezzi et al.   NATURE GENETICS

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE