Article
Chemistry, Inorganic & Nuclear
Tianyu Han, Yuying Wu, Weinan Han, Kaiwen Yan, Jian Zhao, Yanyan Sun
Summary: The facile modification of ligands in organometallic Ru(II)-arene complexes provides more opportunities for optimizing their pharmacological profiles. This study designed and synthesized three Ru(II)-arene complexes containing a GST inhibitor (NBDHEX), with in vitro results showing increased activities against tumor cells, especially in complex 3 which demonstrated the highest activity. Complex 3, with more alkyl groups in the arene ligand, exhibited increased electron density at the Ru(II) center leading to improved hydrolysis rate and higher anticancer activity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Orsolya Domotor, Tamas Pivarcsik, Janos P. Meszaros, Istvan Szatmari, Ferenc Fulop, Eva A. Enyedy
Summary: The study highlighted the interaction between half-sandwich anticancer organometallic complexes and proteins, discussing their binding characteristics with human serum albumin and potential binding sites, providing important insights for the pharmacological and toxicological applications of these compounds.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Janos P. Meszaros, Veronika F. S. Pape, Gergely Szakacs, Gabor Nemeti, Mark Denes, Tamas Holczbauer, Nora V. May, Eva A. Enyedy
Summary: A series of half-sandwich polypyridyl complexes were synthesized and compared for their structural, cytotoxic, and aqueous solution behavior. Introduction of methyl groups near coordinating nitrogen atoms affected steric congestion and changed ligand plane angles. The complexes showed high stability in solution, with Ru complexes susceptible to slow, irreversible decomposition in light exposure.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Abraha Habtemariam, Ana M. Pizarro
Summary: This study introduces a new family of osmium arene complexes and investigates their mechanism of action inside cells. The complexes are shown to catalyze the conversion of organic substrates, demonstrating potential anti-cancer drug activity.
Article
Chemistry, Inorganic & Nuclear
Ashaparna Mondal, Utsav Sen, Nilmadhab Roy, Venkatesan Muthukumar, Suban Kumar Sahoo, Bipasha Bose, Priyankar Paira
Summary: A library of half sandwich Ru(ii)-p-cymene-N<^>N complexes was synthesized using a convenient one pot protocol, showing significant potency and selectivity against cancer cell lines. The Ru(ii)-arene complexes exhibited excellent DNA binding efficacy and fluorescence properties, making them potential candidates for cancer theranostic treatment.
DALTON TRANSACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Oscar A. Lenis Rojas, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes
Summary: The ruthenium arene fragment is a valuable source for designing anticancer drugs, and the co-ligand plays a crucial role in obtaining effective anticancer complexes. N-heterocyclic carbenes (NHCs), despite their versatility and ability to stabilize metal ions, have not been extensively explored. However, recent advancements have been made in the development of NHC ruthenium arene complexes as potent anticancer agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Applied
Ondrej Mozdiak, Pooja Dubey, Libor Dostal, Zdena Ruzickova, Jiri Tydlitat, Roman Jambor
Summary: In this study, we compared the application of different ligands in divalent ruthenium complexes and investigated the effect of stannylene ligand on catalytic oxidation reaction.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Patrycja Rogala, Agnieszka Jablonska-Wawrzycka, Grzegorz Czerwonka, Katarzyna Kazimierczuk, Katarzyna Galczynska, Slawomir Michalkiewicz, Justyna Kalinowska-Tluscik, Marta Karpiel, Karel D. Klika
Summary: This study reports the synthesis and characterization of arene ruthenium complexes containing benzimidazole moiety, which have promising antimicrobial and anticancer activity. The compounds were characterized by various analytical techniques and their molecular structures were determined. Biological studies showed that the complexes exhibit bacteriostatic activity against Pseudomonas aeruginosa PAO1 strain and are non-toxic to normal cells.
Article
Chemistry, Inorganic & Nuclear
Dmitri Gelman, Ilya Kisets, Sofiya Zabelinskaya
Summary: The synthesis and catalytic studies of a prototypical coordinatively rigid carbometalated half-sandwich Ru(II) complex with a rigid polyaromatic tether were described. Despite its coordinatively and electronically saturated nature, the complex demonstrated the ability to activate and transfer hydrogen to polar and nonpolar double bonds. The catalytic activity was benchmarked in the Ru-catalyzed chemoselective hydrogenation of alpha,beta-unsaturated ketones, with initial mechanistic studies suggesting an inner-sphere mechanism via dihydride intermediates.
Article
Chemistry, Applied
Imtiyaz Yousuf, Masrat Bashir
Summary: A new organoruthenium(II) complex was designed, synthesized, and evaluated for cytotoxicity. The complex exhibited significant intermolecular interactions in the crystal structure, and showed preferential affinity toward minor groove in DNA photocleavage activity. Cytotoxic studies revealed moderate but selective activity against pancreatic and cervical cancer cell lines.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Oscar A. Lenis-Rojas, M. Paula Robalo, Ana Isabel Tomaz, Alexandra R. Fernandes, Catarina Roma-Rodrigues, Ricardo G. Teixeira, Fernanda Marques, Monica Folgueira, Julian Yanez, Anabel Alba Gonzalez, Martin Salamini-Montemurri, Dawrin Pech-Puch, Digna Vazquez-Garcia, Margarita Lopez Torres, Alberto Fernandez, Jesus J. Fernandez
Summary: Ruthenium(II) complexes, considered as attractive alternatives to platinum-based drugs, demonstrated significant cytotoxicity against breast cancer cells with lower toxicity towards normal cells, possibly through induction of reactive oxygen species and interaction with protein targets.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Dana Josa, David Aguila, Pere Fontova, Vanessa Soto-Cerrato, Piedad Herrera-Ramirez, Laia Rafols, Arnald Grabulosa, Patrick Gamez
Summary: Five metal-arene complexes and nine cyclometalated half-sandwich complexes were synthesized, characterized, and evaluated for cytotoxicity against human cancer cells. The complexes showed notable cytotoxic properties, particularly against lung adenocarcinoma cells. One of the complexes also exhibited significant toxic effects on other cell lines. Furthermore, the study identified a complex that impacted the cell cycle of lung adenocarcinoma cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Linda Biro, Etelka Farkas, Peter Buglyo
DALTON TRANSACTIONS
(2010)
Article
Chemistry, Inorganic & Nuclear
Etelka Farkas, Edit Csapo, Peter Buglyo, Chiara A. Damante, Giuseppe Di Natale
INORGANICA CHIMICA ACTA
(2009)
Article
Biochemistry & Molecular Biology
Daniele Sanna, Peter Buglyo, Giovanni Micera, Eugenio Garribba
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Sandor Nagy, Andras Ozsvath, Attila Cs Benyei, Etelka Farkas, Peter Buglyo
Summary: Two novel pyridinone-based chelating ligands with separated chelating sets were synthesized and their structures and interactions with metal ions were studied. The results indicate potential for developing anticancer complexes.
Article
Biochemistry & Molecular Biology
Istvan Kacsir, Adrienn Sipos, Attila Benyei, Eszter Janka, Peter Buglyo, Laszlo Somsak, Peter Bai, Eva Bokor
Summary: This study assessed the cytotoxic and cytostatic properties of a set of platinum complexes with bidentate monosaccharide ligands. Five compounds were identified with potent long-term cytostatic activity, making them potential anticancer agents. The findings also revealed the influence of the nature of the ligands and the hydrophobic character of the complexes on their biological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Istvan Kacsir, Adrienn Sipos, Gyula Ujlaki, Peter Buglyo, Laszlo Somsak, Peter Bai, Eva Bokor
Summary: Ruthenium complexes have been developed as alternatives to platinum complexes for the treatment of hematological and gynecological malignancies, showing cytostatic effects on various cancer cell models. These active complexes demonstrated cooperative binding to cellular targets, dependent on reactive oxygen species production. The cytostatic activity of ruthenium complexes was enhanced by the PARP inhibitor Rucaparib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Linda Biro, Peter Buglyo, Etelka Farkas
Summary: In this review, the solution equilibrium results of complexes formed by Pd(II) and two other platinum group metals with hydroxamic acid derivatives, imidazole analogues, and small peptides are summarized and evaluated. The factors determining the coordination modes in these complexes are discussed, along with the options for quantitative evaluation of metal binding effectivity and selectivity.
Review
Biochemistry & Molecular Biology
M. Amelia Santos, Anna Irto, Peter Buglyo, Silvia Chaves
Summary: Hydroxypyridinones (HPs) are versatile chemical tools for engineering metal chelating agents with high affinity for hard metal ions. This review focuses on recent works that utilize hydroxypyridinone-based ligands for environmental applications, specifically the remediation of hard metal ion ecotoxicity. The article outlines the design of new chelating systems and analyzes the relationship between ligand structures and activities, including metal affinity and thermodynamic stability of metal complexes.
Article
Biochemistry & Molecular Biology
Linda Biro, Andras Ozsvath, Reka Kapitany, Peter Buglyo
Summary: A novel ambidentate dipeptide conjugate with potential anticancer activity was synthesized and characterized. The binding behavior of the ligand with Pd(II) and Co(III) was studied, and stable dinuclear complexes were formed. The coordination properties can be tailored by modifying the peptide backbone.
Article
Chemistry, Analytical
Melinda Andrasi, Peter Buglyo, Laszlo Zekany, Attila Gaspar
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2007)
Review
Chemistry, Physical
Yuriy N. Kozlov, Vladimir B. Romakh, Alex Kitaygorodskiy, Peter Buglyo, Georg Suess-Fink, Georgiy B. Shul'pin
JOURNAL OF PHYSICAL CHEMISTRY A
(2007)
Article
Chemistry, Inorganic & Nuclear
Peter Buglyo, Eszter Marta Nagy, Etelka Farkas, Imre Sovago, Daniele Sanna, Giovanni Micera
Article
Chemistry, Inorganic & Nuclear
Etelka Farkas, David Batka, Edit Csapo, Peter Buglyo, Wolfgang Haase, Daniele Sanna
Article
Chemistry, Inorganic & Nuclear
P Buglyó, N Pótári
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chisa Itoh, Haruka Yoshino, Taku Kitayama, Wataru Kosaka, Hitoshi Miyasaka
Summary: A new synthetic route for constructing functional paddlewheel diruthenium(II,II) complexes was developed, utilizing Schiff base condensation reactions. The attached Schiff base groups significantly affected the electronic states of the resulting complexes, as revealed by cyclic voltammetry and DFT calculations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Haozhe Wang, Xianghan Xu, Weiwei Xie, Robert J. Cava
Summary: A layered rhombohedral polymorph of indium(iii) triiodide is synthesized at high pressure and temperature. It has an orange color, which is different from ambient pressure InI3, which has a monoclinic molecular structure and a light-yellow color.
DALTON TRANSACTIONS
(2024)
Review
Chemistry, Inorganic & Nuclear
Juan Carlos Perez-Sanchez, Raquel P. Herrera, M. Concepcion Gimeno
Summary: Gold(II) complexes have been less utilized in catalysis compared to their gold(I) and gold(III) counterparts. However, gold(II) complexes offer potential in homo-coupling and cross-coupling reactions, as they are more easily accessible through simplified oxidation and reduction processes. Gold(II) exhibits characteristics of both soft acid gold(I) and hard acid gold(III). This review explores the unique reactivity and potential applications of gold(II) species, highlighting their significance in catalytic transformations.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Nighat Yousuf, Yanping Ma, Qaiser Mahmood, Wenjuan Zhang, Yizhou Wang, Hassan Saeed, Wen-Hua Sun
Summary: In this study, a series of structurally rigid cyclooctyl-fused iminopyridine iron complexes were synthesized and used with methylaluminoxane for isoprene polymerization. The extent of steric hindrance of the ligand framework was found to significantly affect catalytic performance, with less hindrance leading to better activity and stability.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Chenghao Song, Huiwei Du, Menglei Xu, Jie Yang, Xinyu Zhang, Jungan Wang, Yuanfang Zhang, Chengjun Gu, Rui Li, Tao Hong, Jingji Zhang, Jiangying Wang, Yongchun Ye
Summary: This study improves the performance of perovskite solar cells by using a dual-hole transport layer strategy. This strategy enhances the charge transfer efficiency of the transport layer, reduces charge recombination, and improves the quality of the perovskite film layer. Ultimately, the stability of the device is enhanced.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mahender Singh, Aakash Yadav, Ranjit Singh, Chullikkattil P. Pradeep
Summary: A new aryl selenonium polyoxometalate hybrid was developed and compared with an aryl sulfonium polyoxometalate hybrid in terms of their photocatalytic properties. It was found that the aryl selenonium hybrid exhibited better catalytic performance, which could be attributed to the larger atomic radii of selenium stabilizing the photogenerated electron-hole pair more efficiently. Additionally, the generation of elemental selenium through cleavage of C-Se bonds during catalysis was observed.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yuhan Xie, Boyu Dong, Xuemin Wang, Siyuan Wang, Jinxi Chen, Yongbing Lou
Summary: This study successfully fabricated visible-light-responsive three-dimensional core-shell CoSe2/ZnIn2S4 heterostructures and achieved attractive activity in photocatalytic hydrogen evolution. The presence of CoSe2 improved light absorption and accelerated charge transfer kinetics. The strong interaction between CoSe2 and ZnIn2S4 reduced charge recombination, further enhancing photocatalytic activity for hydrogen evolution.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Andre L. de O. Batista, Joao Marcos T. Palheta, Mauricio J. Piotrowski, Celso R. C. Rego, Diego Guedes-Sobrinho, Alexandre C. Dias
Summary: This study presents a simulation protocol that provides a solid foundation for exploring two-dimensional materials. Using the TiBr2 2H monolayer as an example, the study reveals its promising properties for optoelectronic and valleytronic applications, including its stability, spin-orbit coupling effects, and optical helicity selection rule.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Jiang Jiang, Zi-Wei Li, Zhi-Zhuan Zhang, Bin Tan, Zhao-Feng Wu, Xiao-Ying Huang
Summary: In this work, two metal organic frameworks (MOFs) containing {Cu2I2} clusters, Eu-CuI-INA and Sr-K-CuI-INA, were synthesized and characterized. Both materials have a three-dimensional structure with {Cu2I2} clusters coordinated by INA(-) ligands and Eu3+ or Sr2+ ions. The Sr-K-CuI-INA material exhibited sensitive fluorescence sensing behaviors towards cysteine and nitro-bearing molecules, showing potential applications in bio and explosive molecule sensing. This work provides a good reference for designing fluorescent MOF probes containing CuI molecules.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhiya Lin, Jiasheng Wu, Qianwen Ye, Yulong Chen, Hai Jia, Xiaohui Huang, Shaoming Ying
Summary: Na-ion batteries (NIBs) have attracted great interest as a potential technology for grid-scale energy storage due to the wide distribution, low cost, and environmental friendliness of sodium resources. However, their implementation is hindered by low rate capability and cycling stability caused by the large ionic size of Na+. In this study, a three-dimensional nanoarchitectured coral-like CoSe2@N-doped carbon (CL-CoSe2@NC) was synthesized, and it exhibited improved sodium storage properties with better electrode kinetics and a stable SEI film.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Ya-Qiong Zhang, Yu Zhang, Guoping Zeng, Rong-Zhen Liao, Man Li
Summary: The mechanism and selectivity of CO2 reduction under visible light were investigated using density functional calculations. The results showed that a tetradentate PNNP-type Iridium(III) complex exhibited high activity and selectivity in the reaction.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Sanyukta Ghosh, Shubhanth Jain, Soumya Ranjan Mishra, Gerda Rogl, Peter Rogl, Ernst Bauer, B. S. Murty, A. Govindaraj, Ramesh Chandra Mallik
Summary: In this study, reduced graphene oxide (rGO) was uniformly dispersed in the In0.5Co4Sb12 bulk material by ultrasonication, which effectively reduced the lattice thermal conductivity and improved the thermoelectric efficiency.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Mika Takeuchi, Yutaka Amao
Summary: This study developed an effective visible-light driven system for fumaric acid production using renewable resources such as biomass derivatives, providing an alternative to the current petroleum-based synthesis methods.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Juan Jian, Meiting Wang, Zhuo Wang, Jingwen Meng, Yuqin Yang, Limin Chang
Summary: Developing low-cost and self-supported bifunctional catalysts is crucial for highly efficient water splitting devices. In this study, nano-NiFe2O4 was directly grown onto iron foil surface and Sn4+ was introduced into the NiFe2O4. The resulting Sn-NiFe2O4/IF showed low overpotentials and high current densities during oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), making it a promising catalyst for large-scale hydrogen production.
DALTON TRANSACTIONS
(2024)