Article
Nutrition & Dietetics
Natalia K. Kordulewska, Justyna Topa, Malgorzata Tanska, Anna Cieslinska, Ewa Fiedorowicz, Huub F. J. Savelkoul, Beata Jarmolowska
Summary: Osthole has anti-inflammatory potential in LPS-induced cell inflammatory reactions, reducing cytokine secretion and affecting key gene expressions in a concentration-dependent manner. However, it also increases cell monolayer permeability, so its safety as a potential drug for intestinal inflammatory symptoms should be further confirmed.
Review
Oncology
Jacob T. Hough, Lei Zhao, Marco Lequio, Aidan J. Heslin, Huaping Xiao, Cade C. Lewis, Justin Zhang, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: IL-32 is an interleukin cytokine that is associated with inflammation. It has been found to have both pro- and anti-tumor effects, making its role in cancer formation complex. Considering the role of IL-32 in various cancers and protein pathways is crucial when exploring potential therapeutic options for tumor treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Nutrition & Dietetics
Ying Deng, Coen Govers, Ellen ter Beest, Aalt-Jan van Dijk, Kasper Hettinga, Harry J. Wichers
Summary: In this study, macrophages and dendritic cells derived from THP-1 monocytes were used to investigate allergen recognition and processing. It was found that macrophages exhibited a stronger transcriptional response compared to dendritic cells, especially when exposed to severely structurally modified beta-lactoglobulin. These results indicate the importance of processing in the transcriptional response of innate immune cells towards beta-lactoglobulin.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ebru Cenk, Cornelia Schmutz, Gudrun Pahlke, Anne Oertel, Jessica Kollarova, Hans-Peter Mock, Andrea Matros, Doris Marko
Summary: An anthocyanin-rich diet is believed to protect against chronic inflammation, despite the unclear immunomodulatory role of anthocyanins. The study found that cyanidin-3O-glucoside in blackberry juice can reduce TNF-alpha levels, indicating protective effects, but other fractions from blackberry juice may have pro-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Hitoshi Terui, Yutaka Kimura, Chizu Fujimura, Setsuya Aiba
Summary: This study demonstrated that various haptens can increase the expression of IL-1 alpha and IL-1 beta in human monocyte cell line THP-1, and introduced a stable IL-1 beta reporter cell line THP-G1b for in vitro skin sensitization testing, showing that most haptens can stimulate IL-1 beta reporter activity.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Immunology
Kristin Roseth Aass, Synne Stokke Tryggestad, Robin Mjelle, Martin H. H. Kastnes, Tonje Marie Vikene Nedal, Kristine Misund, Therese Standal
Summary: Multiple myeloma is a type of cancer characterized by the accumulation of malignant plasma cells in the bone marrow. Interleukin-32 (IL-32), a pro-inflammatory cytokine, is expressed in a subgroup of multiple myeloma patients and has been shown to promote the proliferation and survival of cancer cells. This study demonstrates that activation of Toll-like receptors (TLRs) can induce the expression of IL-32 in multiple myeloma cells through NF kappa B activation. The upregulation of TLR genes in individual patients, particularly those sensing bacterial components, coincides with an increase in IL-32 expression, suggesting that infections can induce the expression of this pro-tumorigenic cytokine in multiple myeloma patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pio Conti, Fabrizio E. Pregliasco, Rosa G. Bellomo, Carla E. Gallenga, Alessandro Caraffa, Spyros K. Kritas, Dorina Lauritano, Gianpaolo Ronconi
Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Carys A. Croft, Anna Thaller, Solenne Marie, Jean-Marc Doisne, Laura Surace, Rui Yang, Anne Puel, Jacinta Bustamante, Jean-Laurent Casanova, James P. Di Santo
Summary: The Notch signaling pathway plays a crucial role in the development of innate lymphoid cells (ILCs) from human ILC precursors. The study identifies a Notch->RORC->IL-23R pathway that regulates ILC differentiation. These findings may have implications for expanding functional ILC subsets in vitro and developing novel ILC therapies for human diseases.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Biochemistry & Molecular Biology
Edina Pandur, Kitti Tamasi, Ramona Pap, Gergely Janosa, Katalin Sipos
Summary: Macrophages are essential immune cells that play a fundamental role in fighting bacterial infections through phagocytosis and cytokine secretion. Different bacterial cell wall components have varying effects on cytokine production and iron metabolism in macrophages, ultimately influencing the outcome of bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Yu Shang, Qianyun Liu, Lu Wang, Xinghua Qiu, Yingjun Chen, Jing An
Summary: This study investigates the role of miR-146a-5p in regulating cytokine expression in response to PM2.5 exposure, and finds that autophagy process plays a crucial role in modulating cytokine expression and inflammatory response caused by PM2.5.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: Cytokines play a significant role in immune response regulation. This study focused on Interleukin-32 (IL-32), a cytokine with various isoforms, and found that the theta isoform of IL-32 exhibited the most dominant biological activity in both immune and non-immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Johanna Maria Hoelken, Nicole Teusch
Summary: We have developed a cost-effective and reproducible protocol to differentiate THP-1 cells into iDCs and mDCs. The iDCs are characterized by high expression of CD54 and CD86, and absence of CD83, while the mDCs express CD54, CD86, CD11b, CD83, and CXCR4. Sensitizer treatment increased the expression of CD54 and CD86 in iDCs, making them suitable for toxicological studies. These iDC and mDC surrogates can also be used to study dendritic cell maturation, phagocytosis, migration, and as therapeutic targets in various disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi
Summary: The interaction between thyroid hormones and the immune system involves non-genomic actions mediated by the plasma membrane receptor alpha v beta 3 integrin. Thyroid hormones inhibit IGF-1-stimulated glucose uptake and cell proliferation, and also impact cell migration and proliferation induced by IGF-1 and MCP-1 through integrin alpha v beta 3. This demonstrates a crosstalk between genomic and non-genomic effects in regulating cell physiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Fangyi Shu, Patcharin Thammasit, Kritsada Pruksaphon, Joshua D. D. Nosanchuk, Sirida Youngchim
Summary: This study investigates the expression of cytokine profiles in human THP-1 cells during T. marneffei infection. The results show that as the infection progresses, macrophages undergo slight M1 polarization before shifting to M2 polarization. This polarization transition is confirmed by the fungicidal ability and the expression of macrophage surface markers.
Article
Multidisciplinary Sciences
Suzhao Li, C. Preston Neff, Kristina Barber, Jaewoo Hong, Yuchun Luo, Tania Azam, Brent E. Palmer, Mayumi Fujita, Cecilia Garlanda, Alberto Mantovani, Soohyun Kim, Charles Anthony Dinarello
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Wei-Yu Chen, Jaewoo Hong, Joseph Gannon, Rahul Kakkar, Richard T. Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemistry & Molecular Biology
Seunghyun Jo, Eunsom Kim, Areum Kwak, Jungmin Lee, Jaewoo Hong, Jongho Lee, Sulah Youn, Suyoung Bae, Busun Kim, Soyoon Ryoo, Tae-Bong Kang, Erk Her, Dong-Ki Choi, Yong-Sung Kim, Youngmin Lee, Hyunjhung Jhun, Soohyun Kim
Article
Biochemistry & Molecular Biology
Siyoung Lee, Eunsom Kim, Hyunjhung Jhun, Jaewoo Hong, Areum Kwak, Seunghyun Jo, Suyoung Bae, Jongho Lee, Busun Kim, Jungmin Lee, Sulah Youn, Somi Kim, Miyeon Kim, Hyunwoo Kim, Youngmin Lee, Dong-Ki Choi, Yong-Sung Kim, Soohyun Kim
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Namki Cho, Eun Hye Moon, Hyun Woo Kim, Jaewoo Hong, John A. Beutler, Sang Hyun Sung
Article
Biochemistry & Molecular Biology
Hyunjhung Jhun, Jida Choi, Jaewoo Hong, Siyoung Lee, Areum Kwak, Eunsom Kim, Seunghyun Jo, Soyoon Ryoo, Yoojung Lim, Do-Young Yoon, Jin Tae Hong, Tae Sung Kim, Youngmin Lee, Keeho Song, Soohyun Kim
Article
Immunology
Kwangwon Hong, Youngmin Lee, Siyoung Lee, Sungnoh Hong, Suyoung Bae, Jaewoo Hong, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Taebong Kang, You Sook Cho, Yong-Gil Kim, Soohyun Kim
IMMUNOLOGIC RESEARCH
(2013)
Article
Biotechnology & Applied Microbiology
Soyoon Ryoo, Sukha Lee, Seunghyun Jo, Siyoung Lee, Areum Kwak, Eunsom Kim, Jongho Lee, Jaewoo Hong, Hyunjhung Jhun, Youngmin Lee, Anshul Shyam Sobti, Soohyun Kim, Kwang-Jun Oh
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Siyoung Lee, Youngmin Lee, Kwangwon Hong, Jaewoo Hong, Suyoung Bae, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Charles A. Dinarello, Soohyun Kim
MOLECULAR MEDICINE
(2013)
Article
Multidisciplinary Sciences
Ana-Maria Bulau, Marcel F. Nold, Suzhao Li, Claudia A. Nold-Petry, Michaela Fink, Ashley Mansell, Tobias Schwerd, Jaewoo Hong, Anna Rubartelli, Charles A. Dinarello, Philip Bufler
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Jaewoo Hong, Yurim Kim, Sudhirkumar Yanpallewar, P. Charles Lin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Jaewoo Hong, Yongfen Min, Todd Wuest, P. Charles Lin
Article
Biochemistry & Molecular Biology
Joo-Eun Lee, Fang Bo, Nguyen Thi Thanh Thuy, Jaewoo Hong, Ji Shin Lee, Namki Cho, Hee Min Yoo
Summary: The study demonstrated that lesbicoumestan can induce mitochondrial depolarization on Jurkat cells through MALT1 degradation, inhibiting the NF-kappa B pathway, and exhibiting potential anticancer effects against human leukemia cancer cells.
Article
Biochemistry & Molecular Biology
Chau Ha Pham, Joo-Eun Lee, Jinha Yu, Sung Hoon Lee, Kyung-Rok Yu, Jaewoo Hong, Namki Cho, Seil Kim, Dukjin Kang, Soojin Lee, Hee Min Yoo
Summary: Recent studies have shown that propionic acid inhibits the survival of HeLa cells through inducing autophagy, as well as triggering the production of reactive oxygen species (ROS), mitochondrial membrane dysfunction, and affecting the NF-κB and AKT/mTOR signaling pathways.
Article
Immunology
Jaewoo Hong, Peng Qu, Todd R. Wuest, Haishan Huang, Chuanshu Huang, P. Charles Lin
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
