Genetic epidemiology of osteoarthritis

Gene expression analysis revealsHBP1as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22

(2012) E V A Raine et al.   ANNALS OF THE RHEUMATIC DISEASES

Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

(2012) Julie C. Baker-LePain et al.   ARTHRITIS AND RHEUMATISM

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

(2012)   LANCET

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Osteoarthritis year 2012 in review: genetics and genomics

(2012) J.B.J. van Meurs et al.   OSTEOARTHRITIS AND CARTILAGE

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

(2012) M. C. Castano Betancourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

A Variant in MCF2L Is Associated with Osteoarthritis

(2011) Aaron G. Day-Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type

(2011) Byung-Joo Min et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Mutation in Cartilage Oligomeric Matrix Protein (COMP) Causes Early-Onset Osteoarthritis in a Large Kindred Study

(2011) Shu-Chi Mu et al.   ANNALS OF HUMAN GENETICS

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis

(2011) J. H. Waarsing et al.   ARTHRITIS AND RHEUMATISM

Genetic factors in OA pathogenesis

(2011) Kay Chapman et al.   BONE

Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms

(2011) Ellen S. Regalado et al.   CIRCULATION RESEARCH

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus

(2011) A.W. Dodd et al.   OSTEOARTHRITIS AND CARTILAGE

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

(2011) Serena Sanna et al.   PLoS Genetics

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

(2010) Marylyn D. Ritchie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

(2010) E. Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

(2010) K. Panoutsopoulou et al.   ANNALS OF THE RHEUMATIC DISEASES

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

(2010) A. M. Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

(2010) H.J.M. Kerkhof et al.   OSTEOARTHRITIS AND CARTILAGE

Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group

(2010) R. K. Chaganti et al.   OSTEOPOROSIS INTERNATIONAL

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations

(2009) M. Attur et al.   ANNALS OF THE RHEUMATIC DISEASES

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

The association of proximal femoral shape and incident radiographic hip OA in elderly women

(2009) J.A. Lynch et al.   OSTEOARTHRITIS AND CARTILAGE

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

(2008) K. Chapman et al.   HUMAN MOLECULAR GENETICS

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE