Article
Cell Biology
Arantxa Agote-Aran, Junyan Lin, Izabela Sumara
Summary: Nuclear pore complexes are crucial for macromolecular transport between the nucleus and the cytoplasm. Fragile X-related proteins play a role in the localization of nucleoporins, affecting NPC function. The clearance of cytoplasmic nucleoporin granules is independent of protein translation and is restricted to early G1 phase of the cell cycle.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Bernhard Hampoelz, Janina Baumbach
Summary: This review discusses the role of the nuclear envelope (NE) in protecting and organizing the eukaryotic genome. It explores topics such as NE disassembly and reassembly, variation in surface area and protein composition, and how these factors impact chromatin organization and gene expression in animal development.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Arwa Elaagip, Sabrina Absalon, Anat Florentin
Summary: This article reviews various aspects of organelle dynamics during P. falciparum intracellular replication, summarizes current understanding of these processes, and describes many unanswered questions in this field of parasite basic cell biology.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Gautam Dey, Buzz Baum
Summary: The defining feature of eukaryotic cells, the nucleus, is bounded by a double envelope with nuclear pores critical for separating the genome from the cytoplasm. Eukaryotes have evolved various strategies to remodel the nuclear compartment boundary during mitosis, from disassembling and reassembling the nucleus in daughter cells to maintaining an intact boundary throughout division. This review discusses common features of the division process, topological challenges, and the selective pressures that may drive the evolution of distinct modes of division.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Engineering, Environmental
Xudong Jing, Qiang Sun, Hailiang Jia, Zhenlong Ge, Ting Wang
Summary: This study on the variations in rock pore structure under high-temperature thermal cycles focused on red sandstone from Linyi, Shandong Province. The analysis revealed that the changes in pore structure were primarily caused by the escape of pore water, thermal expansion, and the decomposition of some minerals. Additionally, the proportion of different types of pores were significantly impacted at different temperature ranges, with an increase in mesopores being observed at 573 degrees C and an increase in mesopores after multiple thermal cycles at 600 degrees C.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2021)
Article
Cell Biology
Kristina Mitic, Irene Meyer, Ralph Graef, Marianne Grafe
Summary: The study reveals that the permeabilization of the nuclear envelope in Dictyostelium discoideum occurs in synchrony with centrosome insertion and partial disassembly of nuclear pore complexes. Furthermore, it shows that restoration of nuclear envelope integrity usually happens after reassembly of NPCs and cytokinesis, accompanied by the concentration of ESCRT components at sites of nuclear envelope fenestration.
Article
Thermodynamics
Weizhen Liu, Shiwei Niu, Haibo Tang, Ke Zhou
Summary: The pore structure of lignite plays a crucial role in its high-temperature treatment processes. Research has shown that the connectivity, porosity, and permeability of lignite increase at 250°C, decrease at 350°C, and then increase again at 450°C. At 450°C, the porosity, effective porosity, and permeability of lignite were 18.32%, 30.22%, and 856.98 md, respectively.
CASE STUDIES IN THERMAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Murray Stewart
Summary: Although the nuclear envelope separates the nucleus and cytoplasm in eukaryotes, a semipermeable barrier is necessary to allow material exchange between these compartments. This barrier is achieved through nuclear pores, which facilitate the active transport of macromolecules. The diffusion of macromolecules through these pores is impeded by a dense network of unfolded regions of nucleoporins. Additional mechanisms, such as binding to immobile components and active removal, are required to maintain the distinctive compositions of each compartment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jennifer M. Roehrl, Rouven Arnold, Karima Djabali
Summary: In Hutchinson-Gilford progeria syndrome (HGPS), NPC clustering mainly occurs in dysmorphic nuclei, with a higher frequency in early passages compared to control cells. Progerin does not disrupt the post-mitotic reassembly of NPCs, but leads to NPC clustering in nuclei with high progerin content. Additionally, nuclear envelope defects during replicative senescence result in NPC clustering in senescent cells with dysmorphic nuclei.
Article
Cell & Tissue Engineering
Trishita Basak, Rupasri Ain
Summary: This research reveals a multi-layered regulation of trophoblast self-renewal and differentiation by the Hippo components. YAP translocates to the nucleus in trophoblast stem cells and limits their proliferation by interacting with the stemness factor CDX2. Trophoblast giant cells differentiation is associated with cytoplasmic retention of YAP and decreased level of core Hippo component LATS1.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao, Haihua Ruan
Summary: This article summarizes the types of nuclear localization signals, focuses on recently reported proteins containing such signals, and briefly outlines mechanisms for nuclear entry that do not rely on nuclear localization signals.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biophysics
Juan Sabin, Manuel Alatorre-Meda, Jose Minones Jr, Vicente Dominguez-Arca, Gerardo Prieto
Summary: Polyethylenimine (PEI) has a strong affinity with cell membranes, which sheds light on its mechanism of DNA release. PEI alone cannot enter the cell nucleus but forms a peripheral aureole. The hydrophobic and electrostatic interactions between PEI and lipidic layers allow it to intercalate through the model membranes. This understanding can contribute to the development of better gene therapy and DNA vaccines.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Juan Zheng, Zhen Yang, Huabin Gao, Xiuying Lai, Xiao Wu, Yaolong Huang
Summary: The paper investigates the deformation micro-response of saturated remolded cohesive soil through experiments and nuclear magnetic resonance (NMR) testing. The results show that the pore diameters gradually decrease during loading, resulting in denser and more uniform pores. The loading rate only affects the intermediate state of the soil sample, while the final state is determined by the initial state. Drainage consolidation is complete after a certain dead load time.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Kristina Mitic, Marianne Grafe, Petros Batsios, Irene Meyer
Summary: Dictyostelium cells undergo a semi-closed mitosis, during which the nuclear envelope persists but free diffusion occurs between the cytoplasm and nucleus. Partial disassembly of the nuclear pore complexes allows for permeabilization of the nuclear envelope and facilitates the formation of the mitotic spindle.
Article
Multidisciplinary Sciences
Shiyu Li, Shuting Liu, Zhenning Dai, Qian Zhang, Yichao Xu, Youyu Chen, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun
Summary: The study discovered that viral protein UL16 can enhance mitochondrial function in mammalian cells by promoting mitochondrial metabolism, providing a new theoretical basis for the prevention and treatment of mitochondrial dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yasuhiro Mimura, Masatoshi Takagi, Michaela Clever, Naoko Imamoto
JOURNAL OF CELL SCIENCE
(2016)
Article
Cell Biology
Khondoker Md Zulfiker Rahman, Hiroshi Mamada, Masatoshi Takagi, Shingo Kose, Naoko Imamoto
Article
Biology
Makoto Kimura, Yuriko Morinaka, Kenichiro Imai, Shingo Kose, Paul Horton, Naoko Imamoto
Review
Cell Biology
Naoko Imamoto
CURRENT OPINION IN CELL BIOLOGY
(2018)
Article
Cell Biology
Yutaka Ogawa, Naoko Imamoto
JOURNAL OF CELL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Shingo Kose, Naoko Imamoto
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2014)
Article
Biophysics
Changyong Song, Masatoshi Takagi, Jaehyun Park, Rui Xu, Marcus Gallagher-Jones, Naoko Imamoto, Tetsuya Ishikawa
BIOPHYSICAL JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Yuumi Oda, Makoto Kimura, Shingo Kose, Milo B. Fasken, Anita H. Corbett, Naoko Imamoto
Article
Biochemistry & Molecular Biology
Makoto Kimura, Nobuaki Okumura, Shingo Kose, Toshifumi Takao, Naoko Imamoto
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Correction
Biochemistry & Molecular Biology
Kimio J. Tanaka, Kenji Ogawa, Masatoshi Takagi, Naoko Imamoto, Ken Matsumoto, Masafumi Tsujimoto
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Masatoshi Takagi, Yuko Nishiyama, Atsuko Taguchi, Naoko Imamoto
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Review
Cell Biology
Makoto Kimura, Naoko Imamoto
Article
Biology
Daniel G. Booth, Masatoshi Takagi, Luis Sanchez-Pulido, Elizabeth Petfalski, Giulia Vargiu, Kumiko Samejima, Naoko Imamoto, Chris P. Ponting, David Tollervey, William C. Earnshaw, Paola Vagnarelli
Article
Cell Biology
Takeshi Mizuno, Kei Hirabayashi, Sae Miyazawa, Yurika Kobayashi, Kenta Shoji, Masakazu Kobayashi, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe
Summary: The study investigated the interaction between DNA polymerase alpha and two paralogs of mouse POT1 telomere-binding protein, revealing their roles in lagging strand synthesis. Experimental results showed that the POT1a/b-TPP1-TIN2 complex accumulated in the nucleus, interacted with DNA polymerase alpha, and participated in telomere synthesis.
Article
Biology
Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto
Summary: Hikeshi mediates the nuclear import of HSP70 and regulates its nucleocytoplasmic distribution and functions. Nuclear HSP70 affects the transcriptional activity of HSF1 and nuclear proteostasis. Depletion of Hikeshi leads to reduced nuclear HSP70 levels and up-regulation of HSF1-regulated gene expression.
LIFE SCIENCE ALLIANCE
(2022)