The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions

APOE DNA methylation is altered in Lewy body dementia

(2018) Jessica Tulloch et al.   Alzheimers & Dementia

APOE -ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

(2018) Usman Saeed et al.   Alzheimers & Dementia

The role of glucocerebrosidase in Parkinson disease pathogenesis

(2018) Matthew E. Gegg et al.   FEBS Journal

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

(2018) Rita Guerreiro et al.   LANCET NEUROLOGY

Use of an Alzheimer’s disease polygenic risk score to identify mild cognitive impairment in adults in their 50s

(2018) Mark W. Logue et al.   MOLECULAR PSYCHIATRY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease

(2018) Cornelis Blauwendraat et al.   NEUROBIOLOGY OF AGING

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients

(2017) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Dementia: Skin α-synuclein deposits — a new biomarker for DLB?

(2017) Heather Wood   Nature Reviews Neurology

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies

(2017) Celia Kun-Rodrigues et al.   NEUROBIOLOGY OF AGING

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

A new potential biomarker for dementia with Lewy bodies

(2017) Vincenzo Donadio et al.   NEUROLOGY

The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal

(2017) Victoria Berge-Seidl et al.   NEUROSCIENCE LETTERS

An update on the genetics of dementia with Lewy bodies

(2017) Leonie J.M. Vergouw et al.   PARKINSONISM & RELATED DISORDERS

Mortality in dementia with Lewy bodies compared with Alzheimer’s dementia: a retrospective naturalistic cohort study

(2017) Annabel Price et al.   BMJ Open

Comprehensive Genetic and Mutation Analysis of Familial Dementia with Lewy Bodies Linked to 2q35-q36

(2017) Bram Meeus et al.   JOURNAL OF ALZHEIMERS DISEASE

MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies

(2016) Catherine Labbé et al.   Alzheimers & Dementia

Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource

(2016) Michael J. Keogh et al.   GENOME RESEARCH

Distribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies

(2016) Dagmar H. Hepp et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

GBA Mutations Are Associated With Earlier Onset and Male Sex in Dementia With Lewy Bodies

(2016) Ana Gámez-Valero et al.   MOVEMENT DISORDERS

ADORA1mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies

(2016) Cornelis Blauwendraat et al.   MOVEMENT DISORDERS

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies

(2016) Kyndall Hodges et al.   NEUROBIOLOGY OF AGING

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

(2016) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies

(2016) Joshua T. Geiger et al.   NEUROBIOLOGY OF DISEASE

C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies

(2016) Joshua T. Geiger et al.   Neurodegenerative Diseases

LRRK2 variation and dementia with Lewy bodies

(2016) Michael G. Heckman et al.   PARKINSONISM & RELATED DISORDERS

DNA methylation changes atSNCAintron 1 in patients with dementia with Lewy bodies

(2016) Yu Funahashi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

High Frequency of GBA Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews

(2016) Tamara Shiner et al.   JAMA Neurology

Exome sequencing in dementia with Lewy bodies

(2016) M J Keogh et al.   Translational Psychiatry

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

(2015) O. Lorenzo-Betancor et al.   EUROPEAN JOURNAL OF NEUROLOGY

123I-FP-CIT SPECT in the differential diagnosis between dementia with Lewy bodies and other dementias

(2015) Francesco Brigo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cognitive profile ofLRRK2-related Parkinson's disease

(2015) Sindhu Srivatsal et al.   MOVEMENT DISORDERS

The end of the start for population sequencing

(2015) Ewan Birney et al.   NATURE

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies

(2015) Catherine Labbé et al.   NEUROLOGY

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

(2014) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis

(2014) Sylvie Slaets et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

C9ORF72in Dementia with Lewy bodies

(2014) Andrew Robinson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Apolipoprotein E  2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort

(2014) G. Berge et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism

(2014) Eleanna Kara et al.   JAMA Neurology

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

Functional analysis of 11 novel GBA alleles

(2013) Erika Malini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies – A systematic review and meta-analysis

(2013) Xuxin Lim et al.   PARKINSONISM & RELATED DISORDERS

A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

(2013) Michael A. Nalls et al.   JAMA Neurology

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Psychosis,C9ORF72and dementia with Lewy bodies: Table 1

(2012) Julie S Snowden et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Screening for C9orf72 repeat expansions in parkinsonian syndromes

(2012) Tu-Hsueh Yeh et al.   NEUROBIOLOGY OF AGING

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies

(2012) Martí Colom-Cadena et al.   NEUROBIOLOGY OF AGING

A large study reveals no association between APOE and Parkinson's disease

(2012) Monica Federoff et al.   NEUROBIOLOGY OF DISEASE

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

(2012) D. Tsuang et al.   NEUROLOGY

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

Familial Aggregation of Dementia With Lewy Bodies

(2011) Angela Nervi et al.   ARCHIVES OF NEUROLOGY

DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

(2011) Bram Meeus et al.   NEUROBIOLOGY OF AGING

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Glucocerebrosidase mutations in diffuse Lewy body disease

(2010) Kenya Nishioka et al.   PARKINSONISM & RELATED DISORDERS

Association of Glucocerebrosidase Mutations With Dementia With Lewy Bodies

(2009) Lorraine N. Clark et al.   ARCHIVES OF NEUROLOGY

Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain

(2009) Kenneth D. Cronin et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies

(2009) L. Parnetti et al.   NEUROBIOLOGY OF DISEASE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson’s disease

(2008) K. Markopoulou et al.   ACTA NEUROPATHOLOGICA

Patients Homozygous and Heterozygous for SNCA Duplication in a Family With Parkinsonism and Dementia

(2008) Takeshi Ikeuchi et al.   ARCHIVES OF NEUROLOGY

Early-Onset Familial Lewy Body Dementia With Extensive Tauopathy: A Clinical, Genetic, and Neuropathological Study

(2008) Jordi Clarimón et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CLINICOPATHOLOGIC STUDY OF A SNCA GENE DUPLICATION PATIENT WITH PARKINSON DISEASE AND DEMENTIA

(2008) T. Obi et al.   NEUROLOGY

INTRAFAMILIAL DIVERSITY OF PHENOTYPE ASSOCIATED WITH APP DUPLICATION

(2008) I. Guyant-Marechal et al.   NEUROLOGY

A novel PSEN2 mutation associated with a peculiar phenotype

(2008) P. Piscopo et al.   NEUROLOGY