Journal
NEUROBIOLOGY OF AGING
Volume 49, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.08.023
Keywords
C9orf72; Dementia with Lewy bodies (DLB); Genetic screen
Categories
Funding
- National Institutes of Neurological Disease and Stroke
- Alzheimer's Society
- Lewy Body Society
- Neuroscience Research Australia
- University of New South Wales
- Wellcome Trust
- Medical Research Council
- Canadian Institutes of Health Research
- Ontario Research Fund
- ARUK
- Big Lottery Fund
- Taub Institute
- Panasci Fund
- Parkinson's Disease Foundation
- NIH [NS060113, P50AG008702, P50NS038370, UL1TR000040, AG05131]
- Michael J. Fox Foundation for Parkinson's Research, NINDS R01 [NS078086]
- Little Family Foundation [NS072187]
- Mangurian Foundation Program for Lewy Body Dementia research
- Alzheimer Disease Research Center [P50 AG016547]
- National Institute on Aging [P50 AG016574, U01 AG006786]
- Queen Square Brain Bank at the UCL Institute of Neurology
- Brains for Dementia Research project (Alzheimer's Society)
- Brains for Dementia Research project (ARUK)
- NIHR UCLH Biomedical Research Centre
- Queen Square Dementia Biomedical Research Unit
- Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services [AG000951-12]
- Penn Alzheimer's Disease Core Center [AG10124]
- Penn Morris K. Udall Parkinson's Disease Research Center [NS053488]
- French program Investissements d'avenir [ANR-10-IAIHU-06]
- Helsinki University Central Hospital
- Folkhalsan Research Foundation
- Finnish Academy
- Canadian Consortium on Neurodegeneration in Aging (ER)
- ARUK senior fellowship
- MRC [G1100695, MR/L023784/2, G0900652, G0502157, G0400074, MR/L016397/1, UKDRI-3003, MR/P005748/1, G1100540] Funding Source: UKRI
- Medical Research Council [G0502157, MR/L010305/1, G0400074, MR/L023784/2, UKDRI-3003, G1100695, MR/P005748/1, MR/L016397/1, G1100540, G0900652] Funding Source: researchfish
- Parkinson's UK [J-1403] Funding Source: researchfish
Ask authors/readers for more resources
C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansions in a large cohort of DLB cases and identified no pathogenic repeat expansions in neuropathologically or clinically defined cases, showing that C9orf72 repeat expansions are not causally associated with DLB. (C) 2016 Elsevier Inc. All rights reserved.
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