Journal
NEUROBIOLOGY OF AGING
Volume 45, Issue -, Pages 107-108Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.03.021
Keywords
Dementia with Lewy bodies; Lewy body dementia; RAB39B; Parkinson's disease
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Funding
- Mayo Clinic is a Morris K. Udall PD Research Center of Excellence (NINDS) [P50 NS072187]
- AD Research Center (NIA) [P50 AG16574]
- Little Family Foundation
- Mangurian Foundation
- Mayo Clinic AD
- NINDS [R01 NS078086]
- NIA [R01 AG01586, U01 AG0067866]
- Related Dementias Genetics program
- FRSQ postdoctoral fellowship
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Mutations in Ras-related protein Rab-39B (RAB39B) gene have been linked to X-linked early-onset Parkinsonism with intellectual disabilities. The aim of this study was to address the genetic contribution of RAB39B to Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pathologically confirmed Lewy body dementia (pLBD) cases. A cohort of 884 PD, 399 DLB, and 379 pLBD patients were screened for RAB39B mutations, but no coding variants were found, suggesting RAB39B mutations are not a common cause of PD, DLB, or pLBD in Caucasian population. (C) 2016 Elsevier Inc. All rights reserved.
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