Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

Poly (I:C) therapy decreases cerebral ischaemia/reperfusion injuryviaTLR3-mediated prevention of Fas/FADD interaction

(2014) Xia Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Polyinosinic-Polycytidylic Acid Has Therapeutic Effects against Cerebral Ischemia/Reperfusion Injury through the Downregulation of TLR4 Signaling via TLR3

(2014) P.-F. Wang et al.   JOURNAL OF IMMUNOLOGY

dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects

(2014) Saurabh Chattopadhyay et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance

(2014) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood–spinal cord barrier following ischemia/reperfusion injury in rats

(2014) Xiao-Qian Li et al.   Molecular Brain

Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

(2013) Warrison A. Andrade et al.   Cell Host & Microbe

Identification of TLR downstream pathways in stroke patients

(2013) Dean Wu et al.   CLINICAL BIOCHEMISTRY

Evidence for a detrimental role of TLR8 in ischemic stroke

(2013) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

TLR4, rather than TLR2, regulates wound healing through TGF-β and CCL5 expression

(2013) Hiraku Suga et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TLR-3 receptor activation protects the very immature brain from ischemic injury

(2013) Hui Shi et al.   Journal of Neuroinflammation

Isoquercetin protects cortical neurons from oxygen–glucose deprivation–reperfusion induced injury via suppression of TLR4–NF-кB signal pathway

(2013) Cai-Ping Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo

(2012) Lin-na Pan et al.   ACTA PHARMACOLOGICA SINICA

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

(2012) Takashi Shichita et al.   JOURNAL OF NEUROCHEMISTRY

Poly-ICLC preconditioning protects the blood-brain barrier against ischemic injuryin vitrothrough type I interferon signaling

(2012) Raffaella Gesuete et al.   JOURNAL OF NEUROCHEMISTRY

Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia

(2012) Famakin Bolanle et al.   Journal of Neuroinflammation

Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury

(2012) Ivan Bohacek et al.   Journal of Neuroinflammation

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Toll-Like Receptor 7 Preconditioning Induces Robust Neuroprotection Against Stroke by a Novel Type I Interferon-Mediated Mechanism

(2012) Philberta Y. Leung et al.   STROKE

Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia

(2011) Bolanle M. Famakin et al.   BRAIN RESEARCH

Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

(2011) David Brea et al.   CLINICAL IMMUNOLOGY

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Proof of Concept: Pharmacological Preconditioning with a Toll-like Receptor Agonist Protects against Cerebrovascular Injury in a Primate Model of Stroke

(2011) Frances Rena Bahjat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury

(2011) Amy E B Packard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR2 Ligand Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of Phosphoinositide 3-Kinase/Akt Signaling

(2011) C. Lu et al.   JOURNAL OF IMMUNOLOGY

Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines

(2011) Jian Liang et al.   Journal of Neuroinflammation

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

(2011) Keri B Vartanian et al.   Journal of Neuroinflammation

Multiple Preconditioning Paradigms Converge on Interferon Regulatory Factor-Dependent Signaling to Promote Tolerance to Ischemic Brain Injury

(2011) S. L. Stevens et al.   JOURNAL OF NEUROSCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Blocking TLR2 in vivo Protects against Accumulation of Inflammatory Cells and Neuronal Injury in Experimental Stroke

(2010) Gina Ziegler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR2 activation inhibits embryonic neural progenitor cell proliferation

(2010) Eitan Okun et al.   JOURNAL OF NEUROCHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma

(2010) M. R. Rosenfeld et al.   NEURO-ONCOLOGY

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

(2010) E. Okun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt-Endothelial Nitric Oxide Synthase Pathway in Lipopolysaccharide Preconditioning-Induced Hypoxic-Ischemic Tolerance in the Neonatal Rat Brain

(2010) Hsiang-Yin Lin et al.   STROKE

Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

(2010) Takato Abe et al.   STROKE

Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice

(2009) Fang Hua et al.   BRAIN RESEARCH

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Ischemic Postconditioning as a Novel Avenue to Protect against Brain Injury after Stroke

(2009) Heng Zhao   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR Activation Induces TNF-  Production from Adult Neural Stem/Progenitor Cells

(2009) R. Covacu et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning

(2009) Jesús M. Pradillo et al.   JOURNAL OF NEUROCHEMISTRY

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Upregulated Expression of Toll-Like Receptor 4 in Monocytes Correlates with Severity of Acute Cerebral Infarction

(2008) Qing-wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Akt signaling pathway contributes to postconditioning’s protection against stroke; the protection is associated with the MAPK and PKC pathways

(2008) Xuwen Gao et al.   JOURNAL OF NEUROCHEMISTRY

Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury

(2008) Fang Hua et al.   JOURNAL OF NEUROIMMUNOLOGY

Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation

(2008) J. D. Lathia et al.   JOURNAL OF NEUROSCIENCE

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

(2008) Ulkan Kilic et al.   NEUROBIOLOGY OF DISEASE

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Cerebral Ischemic Lesions on Diffusion-Weighted Imaging Are Associated With Neurocognitive Decline After Cardiac Surgery

(2008) P. Alan Barber et al.   STROKE