The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Is Cognitive Impairment in Cirrhotic Patients Due to Increased Peroxynitrite and Oxidative Stress?

(2015) Carla Gimenez-Garzó et al.   ANTIOXIDANTS & REDOX SIGNALING

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers

(2014) Lana Dokleja et al.   NEUROSCIENCE LETTERS

Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

(2014) J. D. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome

(2013) Jofre Tenorio-Laranga et al.   BIOCHEMICAL PHARMACOLOGY

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease

(2013) Majedeline Belghiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The liver–brain axis in liver failure: neuroinflammation and encephalopathy

(2013) Roger F. Butterworth   Nature Reviews Gastroenterology & Hepatology

Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases

(2013) M.J. Hannula et al.   NEUROSCIENCE

Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

(2013) Saskia A. Overbeek et al.   PLoS One

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney

(2012) Jofre Tenorio-Laranga et al.   BIOCHIMIE

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

(2012) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of a Natural Prolyl Oligopeptidase Inhibitor, Rosmarinic Acid, on Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2012) Xiao Chu et al.   MOLECULES

Hunting for Peptide Substrates of Prolyl Oligopeptidase: Classical Versus Non-Classical Bioactive Peptides

(2011) Jofre Tenorio-Laranga et al.   CNS & Neurological Disorders-Drug Targets

Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research

(2011) Anne Penttinen et al.   CNS & Neurological Disorders-Drug Targets

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

(2011) A. Agusti et al.   GUT

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

(2011) Vicente Felipo et al.   METABOLIC BRAIN DISEASE

Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells

(2011) M. José Moreno-Baylach et al.   NEUROSIGNALS

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

(2010) Saskia Braber et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prolyl oligopeptidase induces angiogenesis bothin vitroandin vivoin a novel regulatory manner

(2010) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequential Expression, Activity and Nuclear Localization of Prolyl Oligopeptidase Protein in the Developing Rat Brain

(2010) Mirva J. Hannula et al.   DEVELOPMENTAL NEUROSCIENCE

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis

(2010) Jofre Tenorio-Laranga et al.   Journal of Neuroinflammation

Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications

(2010) Carmina Montoliu et al.   METABOLIC BRAIN DISEASE

IL-6 and IL-18 in Blood May Discriminate Cirrhotic Patients With and Without Minimal Hepatic Encephalopathy

(2009) Carmina Montoliu et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Issues About the Physiological Functions of Prolyl Oligopeptidase Based on Its Discordant Spatial Association With Substrates and Inconsistencies Among mRNA, Protein Levels, and Enzymatic Activity

(2009) Timo T. Myöhänen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Presence of a Matrix-Derived Neutrophil Chemoattractant in Bronchiolitis Obliterans Syndrome after Lung Transplantation

(2009) M. T. Hardison et al.   JOURNAL OF IMMUNOLOGY

Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen

(2009) Philip J. O'Reilly et al.   JOURNAL OF NEUROIMMUNOLOGY

Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity

(2008) Andis Klegeris et al.   GLIA

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

(2008) Timo T. Myöhänen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity

(2008) Omar Cauli et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging

(2008) M.J. Moreno-Baylach et al.   NEUROSCIENCE

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: A retrograde neurotracing study in the rat brain

(2008) Timo T. Myöhänen et al.   NEUROSCIENCE LETTERS