Brain inflammation and hypertension: the chicken or the egg?

Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

(2014) Pawel J Winklewski et al.   Journal of Neuroinflammation

Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood–brain barrier model

(2014) Josephine Labus et al.   JOURNAL OF NEUROSCIENCE METHODS

Obesity induces neuroinflammation mediated by altered expression of the renin–angiotensin system in mouse forebrain nuclei

(2014) Annette D. de Kloet et al.   PHYSIOLOGY & BEHAVIOR

Time-Dependent Effects of Training on Cardiovascular Control in Spontaneously Hypertensive Rats: Role for Brain Oxidative Stress and Inflammation and Baroreflex Sensitivity

(2014) Gustavo S. Masson et al.   PLoS One

Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

(2014) Keith D. Rochfort et al.   PLoS One

Direct Pro-Inflammatory Effects of Prorenin on Microglia

(2014) Peng Shi et al.   PLoS One

Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin–angiotensin system and proinflammatory cytokines in hypertension

(2014) Qing Su et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Nucleus of the Solitary Tract (Pro)Renin Receptor-Mediated Antihypertensive Effect Involves Nuclear Factor-κB-Cytokine Signaling in the Spontaneously Hypertensive Rat

(2013) Jasenka Zubcevic et al.   HYPERTENSION

Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension

(2013) Wencheng Li et al.   HYPERTENSION

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

Neuroimmune communication in hypertension and obesity: A new therapeutic angle?

(2013) Annette D. de Kloet et al.   PHARMACOLOGY & THERAPEUTICS

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity

(2012) Aline M. Hilzendeger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II AT1receptor blockers as treatments for inflammatory brain disorders

(2012) Juan M. Saavedra   CLINICAL SCIENCE

Brain-Targeted (Pro)renin Receptor Knockdown Attenuates Angiotensin II–Dependent Hypertension

(2012) Wencheng Li et al.   HYPERTENSION

Regional astrogliosis in the mouse hypothalamus in response to obesity

(2012) Laura B. Buckman et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

(2012) Kay LH Wu et al.   Journal of Neuroinflammation

Efficient isolation of live microglia with preserved phenotypes from adult mouse brain

(2012) Maria Nikodemova et al.   Journal of Neuroinflammation

A-type K+channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons

(2012) Yarimar Carrasquillo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise protects against high-fat diet-induced hypothalamic inflammation

(2012) Chun-Xia Yi et al.   PHYSIOLOGY & BEHAVIOR

Upregulation of the Renin-Angiotensin-Aldosterone-Ouabain System in the Brain Is the Core Mechanism in the Genesis of All Types of Hypertension

(2012) Hakuo Takahashi   International Journal of Hypertension

Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats

(2011) Z. Shi et al.   Acta Physiologica

Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR

(2011) Deepmala Agarwal et al.   BASIC RESEARCH IN CARDIOLOGY

The central nervous system and inflammation in hypertension

(2011) Paul J Marvar et al.   CURRENT OPINION IN PHARMACOLOGY

Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-κB in the Paraventricular Nucleus

(2011) Jeffrey P. Cardinale et al.   HYPERTENSION

Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure

(2011) Hiroo Kumagai et al.   HYPERTENSION RESEARCH

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Under pressure: the search for the essential mechanisms of hypertension

(2011) Thomas M Coffman   NATURE MEDICINE

Contributions of vascular inflammation in the brainstem for neurogenic hypertension

(2011) Hidefumi Waki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

(2010) Antony Vinh et al.   CIRCULATION

Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II–Induced Hypertension

(2010) Paul J. Marvar et al.   CIRCULATION RESEARCH

Involvement of the Brain (Pro)renin Receptor in Cardiovascular Homeostasis

(2010) Zhiying Shan et al.   CIRCULATION RESEARCH

Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

(2010) Melania Manco et al.   ENDOCRINE REVIEWS

Neurogenic hypertension

(2010) Julian F. R. Paton et al.   EXPERIMENTAL PHYSIOLOGY

Brain Microglial Cytokines in Neurogenic Hypertension

(2010) Peng Shi et al.   HYPERTENSION

Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling

(2010) Zhi-Hua Zhang et al.   JOURNAL OF HYPERTENSION

Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity

(2010) Yasumasa Endo et al.   JOURNAL OF PERIODONTOLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Obesity induces functional astrocytic leptin receptors in hypothalamus

(2009) H. Hsuchou et al.   BRAIN

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Brain tumour necrosis factor-  modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Pharmacological Treatment for Heart Failure: A View From the Brain

(2009) R B Felder et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure

(2009) Robert B. Felder   EXPERIMENTAL PHYSIOLOGY

Leptin Impairs Cardiovagal Baroreflex Function at the Level of the Solitary Tract Nucleus

(2009) Amy C. Arnold et al.   HYPERTENSION

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Biology of the (Pro)Renin Receptor

(2009) G. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Hypertension Paradox — More Uncontrolled Disease despite Improved Therapy

(2009) Aram V. Chobanian   NEW ENGLAND JOURNAL OF MEDICINE

The subfornical organ: a central nervous system site for actions of circulating leptin

(2008) P. M. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sympathetic modulation of immunity: Relevance to disease

(2008) Denise L. Bellinger et al.   CELLULAR IMMUNOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Altered central catecholaminergic transmission and cardiovascular disease

(2008) S. Kasparov et al.   EXPERIMENTAL PHYSIOLOGY

Mitogen-Activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats

(2008) Shun-Guang Wei et al.   HYPERTENSION

Angiotensin II–Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats

(2008) Shun-Guang Wei et al.   HYPERTENSION

Leptin Signaling in the Nucleus Tractus Solitarii Increases Sympathetic Nerve Activity to the Kidney

(2008) Allyn L. Mark et al.   HYPERTENSION

Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension

(2008) Julian F. R. Paton et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

(2008) Ximena Terra et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Is neurogenic hypertension related to vascular inflammation of the brainstem?

(2008) Julian F.R. Paton et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS