Under pressure: the search for the essential mechanisms of hypertension

AT 1A Angiotensin Receptors in the Renal Proximal Tubule Regulate Blood Pressure

(2011) Susan B. Gurley et al.   Cell Metabolism

Intratubular Renin-Angiotensin System in Hypertension

(2011) L. Gabriel Navar et al.   HYPERTENSION

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension

(2011) ShengYu Mu et al.   NATURE MEDICINE

K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

(2011) M. Choi et al.   SCIENCE

Lymphocyte responses exacerbate angiotensin II-dependent hypertension

(2010) Steven D. Crowley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

(2010) Antony Vinh et al.   CIRCULATION

Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II–Induced Hypertension

(2010) Paul J. Marvar et al.   CIRCULATION RESEARCH

Carotid Baroreceptor Stimulation, Sympathetic Activity, Baroreflex Function, and Blood Pressure in Hypertensive Patients

(2010) Karsten Heusser et al.   HYPERTENSION

Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial

(2010)   LANCET

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

(2010) Christophe Guilluy et al.   NATURE MEDICINE

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

(2010) Simon C. Malpas   PHYSIOLOGICAL REVIEWS

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

(2009) Henry Krum et al.   LANCET

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

The Hypertension Paradox — More Uncontrolled Disease despite Improved Therapy

(2009) Aram V. Chobanian   NEW ENGLAND JOURNAL OF MEDICINE

Innate and adaptive immunity in atherosclerosis

(2009) René R. S. Packard et al.   Seminars in Immunopathology

Global burden of blood-pressure-related disease, 2001

(2008) Carlene MM Lawes et al.   LANCET

Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study

(2008) Alain C Tissot et al.   LANCET

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

(2008) Weizhen Ji et al.   NATURE GENETICS