Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 12, Pages 1125-1129Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2011.560845
Keywords
diabetes; oxidative stress; serum insulin; serum nitric oxide; Solanum xanthocarpum
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Oxidative stress, produced under diabetic conditions, is a possible cause of various forms of tissue damage. The concentrations of antioxidant enzymes in cases of diabetes are significantly decreased, with a concomitant increase in lipid peroxidation. In this study, lupeol, a phytoconstituent from Solanum xanthocarpum, is shown to suppress the progression of diabetes after 21 days. Lupeol treatment caused decreases in glycated haemoglobin, serum glucose and nitric oxide, with a concomitant increase in serum insulin level. Furthermore, treatment with lupeol also increased antioxidant levels, with a decrease in the level of thiobarbituric acid-reactive oxygen species.
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