Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems

Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury

(2014) Binnur Eroglu et al.   JOURNAL OF NEUROCHEMISTRY

The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH-SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Role of nuclear factor kappa B in central nervous system regeneration

(2014) Ronny Haenold et al.   Neural Regeneration Research

A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis

(2014) Francisco J. Carrillo-Salinas et al.   PLoS One

Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities

(2013) Rhoanne C. McPherson et al.   Journal of Neuroimmune Pharmacology

Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice

(2013) Jung Eun Kim et al.   PLoS One

Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines

(2012) Shivaprasad H. Venkatesha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Celastrus and Its Bioactive Celastrol Protect against Bone Damage in Autoimmune Arthritis by Modulating Osteoimmune Cross-talk

(2012) Siddaraju M. Nanjundaiah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease

(2011) Jarod Zepp et al.   TRENDS IN IMMUNOLOGY

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice

(2010) Yanjie Wan et al.   CRITICAL CARE MEDICINE

Th17/Th1 phenotype in demyelinating disease

(2010) L.J. Edwards et al.   CYTOKINE

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

(2010) Bin Peng et al.   Molecular Cancer

Oral Therapy for Multiple Sclerosis — Sea Change or Incremental Step?

(2010) William M. Carroll   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9

(2009) L. Gilles et al.   BLOOD

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation

(2009) Feng Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated fromCelastrus regelii

(2009) D. H. Kim et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results

(2009) G. Comi et al.   Multiple Sclerosis Journal

Induction, function and regulation of IL-17-producing T cells

(2008) Kingston H. G. Mills   EUROPEAN JOURNAL OF IMMUNOLOGY

Determination of T-cell fate by dendritic cells

(2008) Sandra S Diebold   IMMUNOLOGY AND CELL BIOLOGY

Therapeutic effect of tripterine on adjuvant arthritis in rats

(2008) Hong Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET