Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions

Patch Clamp Electrophysiology and Capillary Electrophoresis–Mass Spectrometry Metabolomics for Single Cell Characterization

(2014) Jordan T. Aerts et al.   ANALYTICAL CHEMISTRY

Oxidative stress and schizophrenia

(2014) Francesco E. Emiliani et al.   CURRENT OPINION IN PSYCHIATRY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Untargeted 1H-NMR metabolomics in CSF: Toward a diagnostic biomarker for motor neuron disease

(2014) H. Blasco et al.   NEUROLOGY

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy

(2014) J C Naviaux et al.   Translational Psychiatry

Metabolomic analysis for first-trimester Down syndrome prediction

(2013) Ray O. Bahado-Singh et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

GC-MS-based urine metabolic profiling of autism spectrum disorders

(2013) Patrick Emond et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer’s disease in CRND8 mice

(2013) Shuhai Lin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems

(2013) Urs Meyer   BIOLOGICAL PSYCHIATRY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Colonic bacterial metabolites and human health

(2013) Wendy R Russell et al.   CURRENT OPINION IN MICROBIOLOGY

Metabolomics in Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis: An Untargeted Approach via High-Resolution Mass Spectrometry

(2013) Hélène Blasco et al.   JOURNAL OF PROTEOME RESEARCH

A Combined Metabonomic and Proteomic Approach Identifies Frontal Cortex Changes in a Chronic Phencyclidine Rat Model in Relation to Human Schizophrenia Brain Pathology

(2013) Hendrik Wesseling et al.   NEUROPSYCHOPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo

(2013) R Kaddurah-Daouk et al.   Translational Psychiatry

Alterations in metabolic pathways and networks in Alzheimer’s disease

(2013) R Kaddurah-Daouk et al.   Translational Psychiatry

Brain pathology of spinocerebellar ataxias

(2012) Kay Seidel et al.   ACTA NEUROPATHOLOGICA

Branched-chain amino acids alter neurobehavioral function in rats

(2012) Anna Coppola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Structural Characterization of Plasma Metabolites Detected via LC-Electrochemical Coulometric Array Using LC-UV Fractionation, MS, and NMR

(2012) Susan S. Bird et al.   ANALYTICAL CHEMISTRY

Toward a Predictive Model of Alzheimer’s Disease Progression Using Capillary Electrophoresis–Mass Spectrometry Metabolomics

(2012) Clara Ibáñez et al.   ANALYTICAL CHEMISTRY

Investigation of the Human Brain Metabolome to Identify Potential Markers for Early Diagnosis and Therapeutic Targets of Alzheimer’s Disease

(2012) Stewart F. Graham et al.   ANALYTICAL CHEMISTRY

γ-Aminobutyric acid production by culturable bacteria from the human intestine

(2012) E. Barrett et al.   JOURNAL OF APPLIED MICROBIOLOGY

Metabolomic Analysis of Biochemical Changes in the Plasma and Urine of First-Episode Neuroleptic-Naïve Schizophrenia Patients after Treatment with Risperidone

(2012) Hua-Lin Cai et al.   JOURNAL OF PROTEOME RESEARCH

Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes

(2012) Marc-Emmanuel Dumas   Molecular BioSystems

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

(2012) Christian Czech et al.   PLoS One

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile

(2012) Rima Kaddurah-Daouk et al.   Scientific Reports

A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model

(2011) L. Davidovic et al.   GENOME RESEARCH

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

Broad-Ranging Natural Metabotype Variation Drives Physiological Plasticity in Healthy Control Inbred Rat Strains

(2011) Clément Pontoizeau et al.   JOURNAL OF PROTEOME RESEARCH

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

(2011) Warwick B Dunn et al.   Nature Protocols

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Rett Syndrome: From Bed to Bench

(2011) Shih-Ming Weng et al.   Pediatrics and Neonatology

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library

(2011) Stefano Tiziani et al.   Nature Communications

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept

(2011) R Kaddurah-Daouk et al.   Translational Psychiatry

Metabolomic changes in autopsy-confirmed Alzheimer's disease

(2010) Rima Kaddurah-Daouk et al.   Alzheimers & Dementia

Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis

(2010) Alok Kumar et al.   CLINICA CHIMICA ACTA

Diabetes mellitus in Huntington disease

(2010) Lindsay A. Farrer   CLINICAL GENETICS

Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics

(2010) Y Ji et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Stem Cells: An Overview of the Current Status of Therapies for Central and Peripheral Nervous System Diseases

(2010) A. Orlacchio et al.   CURRENT MEDICINAL CHEMISTRY

The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping

(2010) Judith M. Fonville et al.   JOURNAL OF CHEMOMETRICS

Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls

(2010) Ivan K. S. Yap et al.   JOURNAL OF PROTEOME RESEARCH

Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients

(2010) M K Chan et al.   MOLECULAR PSYCHIATRY

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

(2010) Reza M. Salek et al.   NEUROCHEMISTRY INTERNATIONAL

MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data

(2010) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Homeostatic Imbalance of Purine Catabolism in First-Episode Neuroleptic-Naïve Patients with Schizophrenia

(2010) Jeffrey K. Yao et al.   PLoS One

Metabolic Profiling of Human Blood Serum from Treated Patients with Bipolar Disorder Employing1H NMR Spectroscopy and Chemometrics

(2009) Alessandra Sussulini et al.   ANALYTICAL CHEMISTRY

Analyzing the Effects of Psychotropic Drugs on Metabolite Profiles in Rat Brain Using1H NMR Spectroscopy

(2009) Gerard A. McLoughlin et al.   JOURNAL OF PROTEOME RESEARCH

Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia

(2009) J K Yao et al.   MOLECULAR PSYCHIATRY

Metabonomic Characterization of the 3-Nitropropionic Acid Rat Model of Huntington’s Disease

(2009) T. M. Tsang et al.   NEUROCHEMICAL RESEARCH

Metabolomic Profiling in LRRK2-Related Parkinson's Disease

(2009) Krisztina K. Johansen et al.   PLoS One

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

(2008) M. Bogdanov et al.   BRAIN

CE-MS in metabolomics

(2008) Rawi Ramautar et al.   ELECTROPHORESIS

High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides

(2008) Emanuel Schwarz et al.   JOURNAL OF PROTEOME RESEARCH

Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder

(2008) M J Lan et al.   MOLECULAR PSYCHIATRY

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

(2008) Yolanda de Diego-Otero et al.   NEUROPSYCHOPHARMACOLOGY

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA