Ghrelin Signalling on Food Reward: A Salient Link Between the Gut and the Mesolimbic System

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

(2014) Anthony P Goldstone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility

(2014) A. Cabral et al.   JOURNAL OF NEUROENDOCRINOLOGY

Ghrelin Acts as an Interface between Physiological State and Phasic Dopamine Signaling

(2014) J. J. Cone et al.   JOURNAL OF NEUROSCIENCE

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food

(2014) Rahul Pandit et al.   Obesity

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

(2014) Spring Valdivia et al.   PLoS One

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro

(2013) Zhi Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enteroendocrine hormones—central effects on behavior

(2013) Karolina P Skibicka et al.   CURRENT OPINION IN PHARMACOLOGY

Central Ghrelin Signaling Mediates the Metabolic Response of C57BL/6 Male Mice to Chronic Social Defeat Stress

(2013) Z.R. Patterson et al.   ENDOCRINOLOGY

GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity

(2013) M Merkestein et al.   INTERNATIONAL JOURNAL OF OBESITY

A link between FTO, ghrelin, and impaired brain food-cue responsivity

(2013) Efthimia Karra et al.   JOURNAL OF CLINICAL INVESTIGATION

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake

(2013) Karolina P. Skibicka et al.   NEUROPHARMACOLOGY

Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

(2013) Amparo Romero-Picó et al.   NEUROPSYCHOPHARMACOLOGY

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

(2013) Marie Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models

(2013) Aki Uchida et al.   Frontiers in Neuroscience

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells

(2012) Ichiro Sakata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ghrelin increases the motivation to eat, but does not alter food palatability

(2012) Joost Overduin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Role of Ghrelin in Reward-Based Eating

(2012) Mario Perelló et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling

(2012) Scott E. Kanoski et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Receptor Signaling: A Promising Therapeutic Target for Metabolic Syndrome and Cognitive Dysfunction

(2012) Wei-na Cong et al.   CNS & Neurological Disorders-Drug Targets

GOAT induced ghrelin acylation regulates hedonic feeding

(2012) J.F. Davis et al.   HORMONES AND BEHAVIOR

Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling

(2012) Harriët Schellekens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction

(2012) Ralph J DiLeone et al.   NATURE NEUROSCIENCE

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

The Mysterious Motivational Functions of Mesolimbic Dopamine

(2012) John D. Salamone et al.   NEURON

Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm

(2012) E.W. Lamont et al.   NEUROSCIENCE

Ghrelin Mediates Anticipation to a Palatable Meal in Rats

(2012) Myrte Merkestein et al.   Obesity

Obesity and addiction: neurobiological overlaps

(2012) N. D. Volkow et al.   Obesity Reviews

Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling

(2012) Angela K. Walker et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents

(2012) Agustina Cabral et al.   PLoS One

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

(2012) Mayte Alvarez-Crespo et al.   PLoS One

Ghrelin Influences Novelty Seeking Behavior in Rodents and Men

(2012) Caroline Hansson et al.   PLoS One

Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats

(2012) Stephen V. Mahler et al.   PSYCHOPHARMACOLOGY

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus

(2011) Paul J. Currie et al.   BEHAVIOURAL BRAIN RESEARCH

Ghrelin Interacts with Neuropeptide Y Y1 and Opioid Receptors to Increase Food Reward

(2011) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

(2011) S.J. King et al.   HORMONES AND BEHAVIOR

Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors

(2011) Anne Rediger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Constitutive Activity Is an Intrinsic Feature of Ghrelin Receptor Protein

(2011) Marjorie Damian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin mediates stress-induced food-reward behavior in mice

(2011) Jen-Chieh Chuang et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans

(2011) J. Tong et al.   JOURNAL OF NEUROSCIENCE

Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence

(2011) C. Hansson et al.   NEUROSCIENCE

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

Investigation of the presence of ghrelin in the central nervous system of the rat and mouse

(2011) J.B. Furness et al.   NEUROSCIENCE

Ghrelin and food reward: The story of potential underlying substrates

(2011) Karolina P. Skibicka et al.   PEPTIDES

Low-dose ghrelin infusion — Evidence against a hormonal role in food intake

(2011) Florian Lippl et al.   REGULATORY PEPTIDES

Ghrelin increases intake of rewarding food in rodents

(2010) Emil Egecioglu et al.   ADDICTION BIOLOGY

Stromal cell–specific apoptotic and antiestrogenic mechanisms may explain uterine defects in humans after clomiphene citrate therapy

(2010) Magdalena Nutu et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Dopamine signals for reward value and risk: basic and recent data

(2010) Wolfram Schultz   Behavioral and Brain Functions

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

(2010) Linda A.W. Verhagen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents

(2010) S.L. Dickson et al.   NEUROSCIENCE

Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content

(2010) Emmanuel Disse et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

(2010) Elisabet Jerlhag et al.   PSYCHOPHARMACOLOGY

Ghrelin fluctuation, what determines its production?

(2009) X. Yin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Fasting biases brain reward systems towards high-calorie foods

(2009) Anthony P. Goldstone et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats

(2009) Nicolas Salomé et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synaptic Overflow of Dopamine in the Nucleus Accumbens Arises from Neuronal Activity in the Ventral Tegmental Area

(2009) L. A. Sombers et al.   JOURNAL OF NEUROSCIENCE

Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice

(2009) I.D. Blum et al.   NEUROSCIENCE

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Habituation as a determinant of human food intake.

(2009) Leonard H. Epstein et al.   PSYCHOLOGICAL REVIEW

Characterization of a novel ghrelin cell reporter mouse

(2009) Ichiro Sakata et al.   REGULATORY PEPTIDES

Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine

(2008) Elisabet Jerlhag   ADDICTION BIOLOGY

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens

(2008) Elisabet Jerlhag et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

(2008) Michael Lutter et al.   NATURE NEUROSCIENCE

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood-brain barrier: Connecting the gut and the brain

(2008) William A. Banks   REGULATORY PEPTIDES

Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons

(2008) G. D. Stuber et al.   SCIENCE