Sesquiterpene lactones: Adverse health effects and toxicity mechanisms

ThePlasmodium falciparumCa2+-ATPase PfATP6: insensitive to artemisinin, but a potential drug target

(2015) Bertrand Arnou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lack of Association of the S769N Mutation in Plasmodium falciparum SERCA (PfATP6) with Resistance to Artemisinins

(2012) Long Cui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lethal effect of dehydroleucodine (DhL) on amphibian Bufo arenarum embryos

(2012) Liliana Elizabeth Moreno et al.   FOOD AND CHEMICAL TOXICOLOGY

Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction

(2012) Muhammad Khan et al.   IUBMB LIFE

Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle

(2012) Sara Finaurini et al.   TOXICOLOGY

Multicentre Patch Testing with Compositae Mix by the Swedish Contact Dermatitis Research Group

(2011) M Isaksson et al.   ACTA DERMATO-VENEREOLOGICA

Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part I

(2011) Jacek Wilczynski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Seco-germacrane anhydride: Occurrence of a sesquiterpene lactone in the gorgonian coral Menella sp. (Plexauridae)

(2011) Ping-Jyun Sung et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type-specific induction of apoptosis and mitotic catastrophe

(2011) R. Cotugno et al.   CELL PROLIFERATION

Inhibitory Activities on Mammalian Central Nervous System Receptors and Computational Studies of Three Sesquiterpene Lactones from Coriaria ruscifolia subsp. ruscifolia

(2011) Claudia Pérez et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Comparison of Anti-Invasive Activity of Parthenolide and 3-Isopropyl-2-Methyl-4-Methyleneisoxazolidin-5-One (MZ-6) - A New Compound with α-Methylene-γ-Lactone Motif - on Two Breast Cancer Cell Lines

(2011) Anna Wyrębska et al.   Chemical Biology & Drug Design

Relating Skin Sensitizing Potency to Chemical Reactivity: Reactive Michael Acceptors Inhibit NF-κB Signaling and Are Less Sensitizing than SNAr- and SN2- Reactive Chemicals

(2011) Andreas Natsch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

Searching for Artemisinin Production Improvement in Plants and Microorganisms

(2011) Katarzyna Barbacka et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats

(2011) Christoph Rummel et al.   CYTOKINE

Micronucleus and its applications

(2011) Swapan Samanta et al.   DIAGNOSTIC CYTOPATHOLOGY

Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents

(2011) Xiangrong Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa

(2011) Andrea Chicca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NF-κB-mediated anti-inflammatory activity of the sesquiterpene lactone 7-hydroxyfrullanolide

(2011) Lyle C. Fonseca et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: Evidence for the involvement of adrenergic, dopaminergic and serotonergic systems

(2011) Ana Elisa Gonçalves et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells

(2011) Dalad Siriwan et al.   FITOTERAPIA

Antitrypanosomal sesquiterpene lactones from Saussurea costus

(2011) Tasqiah Julianti et al.   FITOTERAPIA

Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice

(2011) Ivani Aquino et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays

(2011) Neil C. Estabrook et al.   FREE RADICAL BIOLOGY AND MEDICINE

Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species

(2011) Yeong-In Yang et al.   GYNECOLOGIC ONCOLOGY

Modulation of cytotoxic T lymphocyte, natural killer cell, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity byVernonia cinereaL. and vernolide-A in BALB/c mice via enhanced production of cytokines IL-2 and IFN-γ

(2011) Poyil Pratheeshkumar et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

(2011) Vivek Bhakta Mathema et al.   INFLAMMATION

Monitoring of Artemisinin, Dihydroartemisinin, and Artemether in Environmental Matrices Using High-Performance Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)

(2011) Karina Knudsmark Jessing et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitroevaluation of the cytotoxic and genotoxic effects of artemether, an antimalarial drug, in a gastric cancer cell line (PG100)

(2011) Diego Di Felipe Ávila Alcântara et al.   JOURNAL OF APPLIED TOXICOLOGY

Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III

(2011) G. Odonne et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity

(2011) Paola E. Ordóñez et al.   JOURNAL OF ETHNOPHARMACOLOGY

Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea

(2011) Gaudencio M. Natividad et al.   JOURNAL OF ETHNOPHARMACOLOGY

Parthenolide Induces Apoptosis and Cell Cycle Arrest of Human 5637 Bladder Cancer Cells In Vitro

(2011) Guang Cheng et al.   MOLECULES

Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy

(2011) Dhanya Nambiar et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Natural sesquiterpenoids

(2011) Braulio M. Fraga   NATURAL PRODUCT REPORTS

Linderolides A–F, eudesmane-type sesquiterpene lactones and linderoline, a germacrane-type sesquiterpene from the roots of Lindera strychnifolia and their inhibitory activity on NO production in RAW 264.7 cells in vitro

(2011) Hitomi Sumioka et al.   PHYTOCHEMISTRY

Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta

(2011) Antonio M. Fortuna et al.   PHYTOCHEMISTRY

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum

(2011) Mareike Maas et al.   PHYTOCHEMISTRY

Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.)

(2011) Mohammad Majdi et al.   PHYTOCHEMISTRY

Cytotoxic Furanogermacranolides from the Flowers ofHelianthus angustifolius

(2011) Nadine Kretschmer et al.   PLANTA MEDICA

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

(2011) Maria Regina Orofino Kreuger et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

In vitro analysis of the anthelmintic activity of forage chicory (Cichorium intybus L.) sesquiterpene lactones against a predominantly Haemonchus contortus egg population

(2011) Joyce G. Foster et al.   VETERINARY PARASITOLOGY

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

(2011) Praveen Rajendran et al.   Clinical Epigenetics

Hepatocurative potential of sesquiterpene lactones ofTaraxacum officinaleon carbon tetrachloride induced liver toxicity in mice

(2010) A. Mahesh et al.   ACTA BIOLOGICA HUNGARICA

Surface plasmon resonance analysis of nuclear factor-κB protein interactions with the sesquiterpene lactone helenalin

(2010) Berthold Büchele et al.   ANALYTICAL BIOCHEMISTRY

Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi

(2010) Xu-Wen Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells

(2010) Yun Dai et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells

(2010) M Czyz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Screening for Compositae sensitization with pure allergens: implications of molecular structure, strength of reaction, and time of testing

(2010) Evy Paulsen et al.   CONTACT DERMATITIS

Contact and photocontact sensitization in chronic actinic dermatitis: a changing picture

(2010) Ai-Lean Chew et al.   CONTACT DERMATITIS

Toxicity of the antimalarial artemisinin and its dervatives

(2010) Thomas Efferth et al.   CRITICAL REVIEWS IN TOXICOLOGY

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide

(2010) Eva Kmoníčková et al.   FITOTERAPIA

Sesquiterpene lactones from Carpesium rosulatum with potential cytotoxicity against five human cancer cell lines

(2010) Hyung-In Moon et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Sesquiterpene lactone fraction fromArtemisia khorassanicainhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB

(2010) Seyyed Ahmad Emami et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species

(2010) Rajasubramaniam Shanmugam et al.   INTERNATIONAL JOURNAL OF CANCER

Renal toxicity caused by oral use of medicinal plants: The yacon example

(2010) Rejane Barbosa de Oliveira et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of biodistribution and safety of adenovirus vector containing MDR1 in mice

(2010) ZhenZhen Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sesquiterpene Lactones fromAnthemis melanolepisand Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile

(2010) Vasiliki Saroglou et al.   JOURNAL OF NATURAL PRODUCTS

Apoptotic effects of bioactive fraction isolated from Glossogyne tenuifolia on A549 human lung cancer cells

(2010) Hsia-Fen Hsu et al.   Journal of the Taiwan Institute of Chemical Engineers

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Chronic Actinic Dermatitis to Sesquiterpene Lactones: [2+2] Photoreaction Toward Thymidine of (+) and (−) α-Methylene-Hexahydrobenzofuranone with a cis Ring Junction

(2010) Sébastien Fuchs et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity

(2010) Humberto Buskuhl et al.   PHYTOCHEMISTRY

Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.

(2010) Benye Liu et al.   PLANT CELL REPORTS

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species

(2010) Rajasubramaniam Shanmugam et al.   PROSTATE

Costunolide-Induced Apoptosis in Human Leukemia Cells: Involvement of c-Jun N-Terminal Kinase Activation

(2009) Jung-Hye Choi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)

(2009) Sundar Neelakantan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Studies on the Constituents of Whole Plants of Youngia japonica

(2009) Emiko Yae et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

α-methylene-γ-butyrolactones: versatile skin bioactive natural products

(2009) Jean-Pierre Lepoittevin et al.   CHEMICAL RECORD

Molluscicidal Sesquiterpene Lactones from Species of the TribeVernonieae(Compositae)

(2009) Susana Borkosky et al.   CHEMISTRY & BIODIVERSITY

New agents for the treatment of leukemia: discovery of DMAPT (LC-1)

(2009) Kevin Peese   DRUG DISCOVERY TODAY

DEGRADATION AND ECOTOXICITY OF THE BIOMEDICAL DRUG ARTEMISININ IN SOIL

(2009) Karina K. Jessing et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Sesquiterpene lactones from Sonchus arvensis L. and their antibacterial activity against Streptococcus mutans ATCC 25175

(2009) Zhengxiang Xia et al.   FITOTERAPIA

Distinguishing Chinese Star Anise from Japanese Star Anise Using Thermal Desorption−Gas Chromatography−Mass Spectrometry

(2009) Melanie-Jayne R. Howes et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sesquiterpene lactones fromIxeris sonchifoliaHance and their cytotoxicities on A549 human non-small cell lung cancer cells

(2009) Yao-Chun Zhang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Sesquiterpene lactones with antinociceptive and antipyretic activity from two Centaurea species

(2009) Esra Küpeli Akkol et al.   JOURNAL OF ETHNOPHARMACOLOGY

Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

(2009) Z. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions

(2009) Y.N. V. Gopal et al.   MOLECULAR CANCER THERAPEUTICS

Pharmacologic inhibitors of I B kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo

(2009) A. I. Idris et al.   MOLECULAR CANCER THERAPEUTICS

2β-(Isobutyryloxy)florilenalin, a Sesquiterpene Lactone Isolated from the Medicinal Plant Centipeda minima, Induces Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells

(2009) Miaoxian Su et al.   MOLECULES

Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones

(2009) Thomas Schmidt et al.   MOLECULES

Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis

(2009) Damian Paul Drew et al.   PHYTOCHEMISTRY REVIEWS

Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide

(2009) Jolanta Skalska et al.   PLoS One

Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach

(2009) Brian T. Kawasaki et al.   PROSTATE

Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

(2009) Robert L. Clark   REPRODUCTIVE TOXICOLOGY

Epigenetic Changes in Cancer

(2008) Christine A. Iacobuzio-Donahue   Annual Review of Pathology-Mechanisms of Disease

Can we finally target the leukemic stem cells?

(2008) Craig T. Jordan   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Artesunate: developmental toxicity and toxicokinetics in monkeys

(2008) Robert L. Clark et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Developmental toxicity of artesunate in the rat: comparison to other artemisinins, comparison of embryotoxicity and kinetics by oral and intravenous routes, and relationship to maternal reticulocyte count

(2008) Robert L. Clark et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles

(2008) Qigui Li et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Sensitive periods for developmental toxicity of orally administered artesunate in the rat

(2008) Tacey E.K. White et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Nuclear factor-κB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia

(2008) Christopher Jenkins et al.   BRITISH JOURNAL OF HAEMATOLOGY

Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds

(2008) S H Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anticancer activities of sesquiterpene lactones from Cyathocline purpurea in vitro

(2008) Guoyi Ma et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair

(2008) P. C.H. Li et al.   CANCER RESEARCH

The Role of Parthenolide in Intracellular Signalling Processes: Review of Current Knowledge

(2008) Luis Bedoya et al.   Current Signal Transduction Therapy

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

(2008) Beata Pajak et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Structure-hepatoprotective activity relationship study of sesquiterpene lactones: A QSAR analysis

(2008) Yuliya Paukku et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic

(2008) Andy T.Y. Lau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Natural Sesquiterpene Lactones are Active Against Leishmania mexicana

(2008) Patricia A. Barrera et al.   JOURNAL OF PARASITOLOGY

Parthenolide Induces Apoptosis in Glioblastomas Without Affecting NF-κB

(2008) Krystal N. Anderson et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Chemical composition and biological activity of the acetone extract of Ambrosia artemisiifolia L. pollen

(2008) Slavica Solujic et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Sesquiterpene Lactones and their Anti-Tumor Activity from the Flowers of Inula Britannica

(2008) Jin-Long Qi et al.   Letters in Drug Design & Discovery

Natural sesquiterpenoids

(2008) Braulio M. Fraga   NATURAL PRODUCT REPORTS

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways

(2008) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines

(2007) Sharon Rozenblat et al.   BIOCHEMICAL PHARMACOLOGY

Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis

(2007) Berrin Özçelik et al.   MICROBIOLOGICAL RESEARCH