Article
Plant Sciences
So-Ri Son, In Gyong Ju, Jinhee Kim, Keon-Tae Park, Myung Sook Oh, Dae Sik Jang
Summary: This study identified chemical constituents from the aerial parts of Artemisia iwayomogi that have anti-neuroinflammatory properties, inhibiting microglial activation and nitric oxide production. Further in vivo experiments are needed to validate these findings.
Article
Plant Sciences
Hua-Rong Zhao, Xiao-Qin Liu, Xiu-Tao Wu, Ling-Yi Kong, Jian-Guang Luo
Summary: Four new highly oxidized sesquiterpene lactones, Argyoxynolides A-D, were isolated from Artemisia argyi H.Le ' v. & Vaniot, along with two known analogs. One of the compounds showed inhibitory activity against LPS-induced nitric oxide production, with an IC50 value of 37.95 +/- 4.39 μM. The structures of these compounds were characterized using extensive spectroscopic methods.
PHYTOCHEMISTRY LETTERS
(2021)
Editorial Material
Parasitology
Bruno Douradinha
Summary: The pro-apoptotic action of peroxynitrite may contribute to the attenuated protection mediated by malarial sporozoite.
TRENDS IN PARASITOLOGY
(2023)
Article
Parasitology
Abeer E. Saad, Hager S. Zoghroban, Heba B. Ghanem, Dina M. El-Guindy, Salwa S. Younis
Summary: The study aimed to assess the impact of L-citrulline, alone or in combination with SMZ-TMP, on acute toxoplasmosis. The results showed that combined treatment with L-citrulline and SMZ-TMP increased survival time, reduced tachyzoite numbers, and improved liver cell damage and inflammatory infiltration.
Article
Medicine, Research & Experimental
N. Tursunova, V. N. Syrov, Z. A. Khushbaktova, Yu Tornuev, M. G. Klinnikova
Summary: After a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg) in rats with toxic CCl4-induced hepatitis, significant changes in enzyme activities of phases I and II of xenobiotic biotransformation and parameters of NO metabolism were observed in liver microsomes, suggesting that sesquiterpene lactones can stimulate the recovery of the cytochrome P-450 system and NOergic system.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Organic
Weilong Liu, Nicolas Winssinger
Summary: The review summarizes new approaches to alpha-exo-methylene-gamma-butyrolactones developed over the past decade as well as their applications in total synthesis, highlighting the significance of the alpha-exo-methylene-gamma-butyiolactone moiety in structurally diverse natural products.
SYNTHESIS-STUTTGART
(2021)
Article
Biochemistry & Molecular Biology
Jana Samarin, Piotr Fabrowski, Roman Kurilov, Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru, Hamed Alborzinia, Umut Yildiz, Laura Grob, Minerva Taubert, Marie Czech, Michael Morgen, Christina Brandstaedter, Katja Becker, Lianghao Mao, Ashok Kumar Jayavelu, Angela Goncalves, Ulrike Uhrig, Jeanette Seiler, Yanhong Lyu, Sven Diederichs, Ursula Klingmueller, Martina Muckenthaler, Annette Kopp-Schneider, Aurelio Teleman, Aubry K. Miller, Nikolas Gunkel
Summary: A study found a set of antioxidant-capacity biomarkers (ACB) in lung cancer cell lines, which are repressed by STAT3 and STAT5A/B in sensitive cells, making them susceptible to redox-targeting and ferroptosis-inducing drugs. Low ACB expression was associated with a high level of nitric oxide instead of reactive oxygen species (ROS), which is required for high replication rates. ACB expression pattern can help stratify cancer patients for clinical trials of ROS-inducing drugs.
Article
Pharmacology & Pharmacy
Amanda de Carvalho Pereira, Alice Valenca Araujo, Michele Paulo, Roberto Santana da Silva, Lusiane Maria Bendhack
Summary: RuBPY decreases intracellular calcium concentration by blocking calcium influx and activating the guanylyl cyclase-cGMP-GK pathway, resulting in reduced vascular contraction. These findings suggest that RuBPY increases Ca2+ storage through SERCA activation and inhibition of capacitive Ca2+ influx.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Nguyen Thi Viet Thanh, Dang Thanh Tung, Le Van Duong, Tran Thi Minh, Vu Dinh Hoang, Seo Young Yang, Pham Hai Yen
Summary: In this study, two new chlorinated guaianane-type sesquiterpenes were isolated from the leaves and twigs of Sigesbeckia orientalis, along with eight known compounds. The structures and configurations of these compounds were determined by various analytical techniques. One of the new compounds, chlosigesolide A, exhibited significant inhibitory activity against NO production in LPS-stimulated macrophages.
NATURAL PRODUCT RESEARCH
(2023)
Article
Microbiology
Ophelie Rutschmann, Chiara Toniolo, John D. McKinney
Summary: In this report, we demonstrated that fluctuations in the expression of antimicrobial genes can define how single host cells control bacterial infections. We showed that preexisting cell-to-cell variation in the expression of a single gene, that for inducible nitric oxide synthase, is sufficient to explain why some macrophages kill intracellular M. tuberculosis while others fail to control bacterial replication, possibly leading to disease progression. We introduced the concept that chance encounters between heterogeneous bacteria and host cells can determine the outcome of a host-pathogen interaction. This concept is particularly relevant for all the infectious diseases in which the number of interacting pathogens and host cells is small at some point during the infection.
Article
Chemistry, Medicinal
Negar Omidkhah, Razieh Ghodsi
Summary: NO-HDAC dual inhibitors have demonstrated satisfactory therapeutic effects in various diseases and possess high therapeutic potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meng Liy Pan, Nur Nabilah Ahmad Puzi, Yin Yin Ooi, Rajesh Ramasamy, Sharmili Vidyadaran
Summary: The latest research shows that microglia phenotype is not limited to the binary states of "resting" and "activated", but exhibits wide diversity. Testing different stimulation protocols for BV2 microglia, we found differences in the response of the cells in terms of intracellular ROS, nitric oxide, CD40 expression, and migratory capacity.
Article
Immunology
Avik Chattopadhyay, Joel P. Joseph, Sirisha Jagdish, Somak Chaudhuri, Nikita S. Ramteke, Aagosh Kishore Karhale, Uchenna Waturuocha, Deepak Kumar Saini, Dipankar Nandi
Summary: This study identified novel non-steroidal small molecule inhibitors of interferon gamma (IFN-γ)-induced nitric oxide (NO) production through screening on a mouse hepatoma cell line. The most potent compounds were pentamidine and auranofin, which showed significant protection in the models of ulcerative colitis and sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katharina Possart, Fabian C. Herrmann, Joachim Jose, Maria P. Costi, Thomas J. Schmidt
Summary: This paragraph introduces a new method for treating insomnia, which improves sleep quality by adjusting the alpha wave frequency of the brain.
Article
Oncology
Toru Sakatani, Yuki Kita, Masakazu Fujimoto, Takeshi Sano, Akihiro Hamada, Kenji Nakamura, Hideaki Takada, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi
Summary: The study investigated the expression of immune markers in the tumor microenvironment of 26 advanced urothelial carcinoma patients receiving Pembrolizumab treatment. High levels of CD8(+) tumor-infiltrating lymphocytes were associated with favorable objective responses, progression-free survival, and overall survival. Additionally, high interferon-gamma (IFN gamma) expression levels were linked to longer post-progression survival. Low infiltration of CD8(+) TILs and low IFN gamma expression were identified as an independent prognostic factor for an unfavorable response to Pembrolizumab.
Article
Biochemistry & Molecular Biology
Zdenek Zidek, Miloslav Kverka, Adela Dusilova, Eva Kmonickova, Petr Jansa
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Silvia Pazourekova, Marianna Lucova, Radomir Nosal, Katarina Drabikova, Juraj Harmatha, Jan Smidrkal, Viera Jancinova
Article
Immunology
L'udmila Paskova, Viera Kuncirova, Silvester Ponist, Danica Mihalova, Radomir Nosal, Juraj Harmatha, Iveta Hradkova, Tomas Cavojsky, Frantisek Bilka, Katarina Siskova, Ingrid Paulikova, Lydia Bezakova, Katarina Bauerova
JOURNAL OF IMMUNOLOGY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Michal Jurasek, Petr Dzubak, Silvie Rimpelova, David Sedlak, Petr Konecny, Ivo Frydrych, Sona Gurska, Marian Hajduch, Katerina Bogdanova, Milan Kolar, Tomas Mueller, Eva Kmonickova, Tomas Ruml, Juraj Harmatha, Pavel B. Drasar
Article
Biochemistry & Molecular Biology
Lukas Huml, Michal Jurasek, Petra Miksatkova, Tomas Zimmermann, Pavla Tomanova, Milos Budesinsky, Zdenka Rottnerova, Marketa Simkova, Juraj Harmatha, Eva Kmonickova, Oldrich Lapcik, Pavel B. Drasar
Article
Chemistry, Medicinal
Juraj Harmatha, Milos Budesinsky, Michal Jurasek, Tomas Zimmermann, Pavel Drasar, Zdenek Zidek, Eva Kmonickova, Lucie Vejvodova
Review
Cell Biology
Hassan Farghali, Mighty Kgalalelo Kemelo, Nikolina Kutinova Canova
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Chemistry, Organic
Silvie Rimpelova, Michal Jurasek, Lucie Peterkova, Jiri Bejcek, Vojtech Spiwok, Milos Majdl, Michal Jirasko, Milos Budesinsky, Juraj Harmatha, Eva Kmonickova, Pavel Drasar, Tomas Ruml
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Juraj Harmatha, Milos Budesinsky, Zdenek Zidek, Eva Kmonickova
Summary: In this study, three structurally related spirostanol saponins were isolated and identified from leek flowers. One of them is a new component, while the other two are identical to known constituents of leek plants. The cytotoxicity and effects on NO production in mouse peritoneal cells of these saponins were tested, with 6-deoxyaginoside showing the highest inhibitory effects and a close correlation between toxicity and NO production inhibition observed.
Article
Pharmacology & Pharmacy
Mahak Arora, Nikolina Kutinova Canova, Hassan Farghali
Summary: This review provides a brief overview of the mechanism behind the progression of non-alcoholic fatty liver disease (NAFLD) to chronic non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular cancer. The review highlights the potential of targeting mTOR as a treatment for NASH, due to its significant role in lipogenesis and alleviating inflammation and fibrosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Organic
Ludmila Skorpilova, Silvie Rimpelova, Michal Jurasek, Milos Budesinsky, Jana Lokajova, Roman Effenberg, Petr Slepicka, Tomas Ruml, Eva Kmonivkova, Pavel B. Drasar, Zdenek Wimmer
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Mighty Kgalalelo Kemelo, Aneta Pierzynova, Nikolina Kutinova Canova, Tomas Kucera, Hassan Farghali
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Pharmacology & Pharmacy
M. K. Kemelo, A. Horinek, N. K. Canova, H. Farghali
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2016)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
