The ESCRT machinery: From the plasma membrane to endosomes and back again

Membrane Fission Reactions of the Mammalian ESCRT Pathway

(2013) John McCullough et al.   Annual Review of Biochemistry

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation

(2013) Nicholas J. Buchkovich et al.   DEVELOPMENTAL CELL

MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain

(2013) Naoko Iwaya et al.   JOURNAL OF BIOCHEMISTRY

Relief of Autoinhibition Enhances Vta1 Activation of Vps4 via the Vps4 Stimulatory Element

(2013) Andrew P. Norgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules

(2013) Rebecca A. Green et al.   JOURNAL OF CELL BIOLOGY

Electron cryotomography of ESCRT assemblies and dividing Sulfolobus cells suggests that spiraling filaments are involved in membrane scission

(2013) Megan J. Dobro et al.   MOLECULAR BIOLOGY OF THE CELL

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

(2013) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane

(2013) J. R. Mayers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wrapping up the bad news – HIV assembly and release

(2013) Bo Meng et al.   Retrovirology

ESCRT requirements for EIAV budding

(2013) Virginie Sandrin et al.   Retrovirology

ESCRT-III Assembly and Cytokinetic Abscission Are Induced by Tension Release in the Intercellular Bridge

(2013) J. Lafaurie-Janvore et al.   SCIENCE

How to get out: ssRNA enveloped viruses and membrane fission

(2013) Winfried Weissenhorn et al.   Current Opinion in Virology

Computational Model of Cytokinetic Abscission Driven by ESCRT-III Polymerization and Remodeling

(2012) Natalie Elia et al.   BIOPHYSICAL JOURNAL

The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices

(2012) William Mike Henne et al.   CELL

Regulation of Endocytic Clathrin Dynamics by Cargo Ubiquitination

(2012) Anastasia G. Henry et al.   DEVELOPMENTAL CELL

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

(2012) Sang-Oh Han et al.   EMBO REPORTS

Interactions of the Human LIP5 Regulatory Protein with Endosomal Sorting Complexes Required for Transport

(2012) Jack J. Skalicky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase

(2012) M. R. G. Russell et al.   JOURNAL OF CELL SCIENCE

CC2D1A Is a Regulator of ESCRT-III CHMP4B

(2012) Nicolas Martinelli et al.   JOURNAL OF MOLECULAR BIOLOGY

Midbody assembly and its regulation during cytokinesis

(2012) Chi-Kuo Hu et al.   MOLECULAR BIOLOGY OF THE CELL

In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters

(2012) L.-A. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for membrane targeting by the MVB12-associated  -prism domain of the human ESCRT-I MVB12 subunit

(2012) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

(2012) Monica Agromayor et al.   STRUCTURE

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis

(2011) Michael A. McMurray et al.   BIOLOGICAL CHEMISTRY

ESCRT-III Protein Requirements for HIV-1 Budding

(2011) Eiji Morita et al.   Cell Host & Microbe

UBAP1 Is a Component of an Endosome-Specific ESCRT-I Complex that Is Essential for MVB Sorting

(2011) Flavia Stefani et al.   CURRENT BIOLOGY

Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast

(2011) Xuefeng Ren et al.   EMBO JOURNAL

Charged Multivesicular Body Protein 2B (CHMP2B) of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) Polymerizes into Helical Structures Deforming the Plasma Membrane

(2011) Gilles Bodon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of the Endosomal Sorting Complex ESCRT-II with the Vps20 Subunit of ESCRT-III Generates a Curvature-sensitive Complex Capable of Nucleating ESCRT-III Filaments

(2011) Ian Fyfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination

(2011) Daniel K. Stringer et al.   JOURNAL OF CELL BIOLOGY

Multivesicular bodies in the enigmatic amoeboflagellate Breviata anathema and the evolution of ESCRT 0

(2011) E. K. Herman et al.   JOURNAL OF CELL SCIENCE

Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division

(2011) Rachel Y. Samson et al.   MOLECULAR CELL

Proteomic snapshot of the EGF-induced ubiquitin network

(2011) E. Argenzio et al.   Molecular Systems Biology

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity

(2011) Tse-Chun Kuo et al.   NATURE CELL BIOLOGY

Shaping development with ESCRTs

(2011) Tor Erik Rusten et al.   NATURE CELL BIOLOGY

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission

(2011) N. Elia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy

(2011) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical Constriction During Abscission Involves Helices of ESCRT-III-Dependent Filaments

(2011) J. Guizetti et al.   SCIENCE

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH

(2011) Julianna Solomons et al.   STRUCTURE

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

Regulation of Membrane Protein Degradation by Starvation-Response Pathways

(2011) Charles B. Jones et al.   TRAFFIC

Endosomal transport via ubiquitination

(2011) Robert C. Piper et al.   TRENDS IN CELL BIOLOGY

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

ERBB2 is a target for USP8-mediated deubiquitination

(2010) Inez M.J. Meijer et al.   CELLULAR SIGNALLING

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

(2010) Xuefeng Ren et al.   EMBO JOURNAL

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation

(2010) David Teis et al.   EMBO JOURNAL

Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition

(2010) Samuel A. Merrill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT-0 Assembles as a Heterotetrameric Complex on Membranes and Binds Multiple Ubiquitinylated Cargoes Simultaneously

(2010) Jonathan R. Mayers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

(2010) Mathew P. Estey et al.   JOURNAL OF CELL BIOLOGY

Multiple Interactions between the ESCRT Machinery and Arrestin-Related Proteins: Implications for PPXY-Dependent Budding

(2010) S. Rauch et al.   JOURNAL OF VIROLOGY

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Regulators of Vps4 ATPase Activity at Endosomes Differentially Influence the Size and Rate of Formation of Intralumenal Vesicles

(2010) Daniel P. Nickerson et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Evolution of diverse cell division and vesicle formation systems in Archaea

(2010) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

(2010) E. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

Structural Role of the Vps4-Vta1 Interface in ESCRT-III Recycling

(2010) Dong Yang et al.   STRUCTURE

Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction

(2010) Young Jun Im et al.   STRUCTURE

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

(2009) Jian Jiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional Reconstitution of ESCRT-III Assembly and Disassembly

(2009) Suraj Saksena et al.   CELL

Structure and Function of the ESCRT-II-III Interface in Multivesicular Body Biogenesis

(2009) Young Jun Im et al.   DEVELOPMENTAL CELL

Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5

(2009) Catherine Sem Wegener et al.   HISTOCHEMISTRY AND CELL BIOLOGY

ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting

(2009) S. Brookhart Shields et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

(2009) J.-A Lee et al.   JOURNAL OF NEUROSCIENCE

Recruitment of the ESCRT Machinery to a Putative Seven-Transmembrane-Domain Receptor Is Mediated by an Arrestin-Related Protein

(2009) A. Herrador et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Role of hIST1 in Cytokinesis

(2009) Monica Agromayor et al.   MOLECULAR BIOLOGY OF THE CELL

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Structural basis for ESCRT-III protein autoinhibition

(2009) Monika Bajorek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Three-Dimensional Structure of AAA ATPase Vps4: Advancing Structural Insights into the Mechanisms of Endosomal Sorting and Enveloped Virus Budding

(2009) Michael John Landsberg et al.   STRUCTURE

Hybrid Structural Model of the Complete Human ESCRT-0 Complex

(2009) Xuefeng Ren et al.   STRUCTURE

A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments

(2009) Ricardo Pires et al.   STRUCTURE

Cytokinetic abscission: cellular dynamics at the midbody

(2009) Patrick Steigemann et al.   TRENDS IN CELL BIOLOGY

Computational Model of Membrane Fission Catalyzed by ESCRT-III

(2009) Gur Fabrikant et al.   PLoS Computational Biology

A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes

(2008) Joseph D. Dukes et al.   BIOCHEMICAL JOURNAL

Final Stages of Cytokinesis and Midbody Ring Formation Are Controlled by BRUCE

(2008) Christian Pohl et al.   CELL

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Recruitment of Tom1L1/Srcasm to Endosomes and the Midbody by Tsg101

(2008) Yuko Yanagida-Ishizaki et al.   CELL STRUCTURE AND FUNCTION

Structural Basis of Vta1 Function in the Multivesicular Body Sorting Pathway

(2008) Junyu Xiao et al.   DEVELOPMENTAL CELL

ESCRT-III Family Members Stimulate Vps4 ATPase Activity Directly or via Vta1

(2008) Ishara F. Azmi et al.   DEVELOPMENTAL CELL

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Two Distinct Modes of ESCRT-III Recognition Are Required for VPS4 Functions in Lysosomal Protein Targeting and HIV-1 Budding

(2008) Collin Kieffer et al.   DEVELOPMENTAL CELL

Integrated Structural Model and Membrane Targeting Mechanism of the Human ESCRT-II Complex

(2008) Young Jun Im et al.   DEVELOPMENTAL CELL

Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components

(2008) Albert F. Ellen et al.   EXTREMOPHILES

Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor

(2008) Sudha K. Shenoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

(2008) Phyllis I. Hanson et al.   JOURNAL OF CELL BIOLOGY

Biochemical and Structural Studies of Yeast Vps4 Oligomerization

(2008) Malgorzata D. Gonciarz et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM Structure of Dodecameric Vps4p and Its 2:1 Complex with Vta1p

(2008) Zhiheng Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Vacuolar Protein Sorting: Two Different Functional States of the AAA-ATPase Vps4p

(2008) Claudia Hartmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Autoinhibition of ESCRT-III CHMP3

(2008) Suman Lata et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel Interactions of ESCRT-III with LIP5 and VPS4 and their Implications for ESCRT-III Disassembly

(2008) Soomin Shim et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

(2008) Dong Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release

(2008) J. G. Carlton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A unique cell division machinery in the Archaea

(2008) A.-C. Lindas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALIX-CHMP4 interactions in the human ESCRT pathway

(2008) J. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the ESCRT System in Cell Division in Archaea

(2008) R. Y. Samson et al.   SCIENCE

Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55

(2008) H. H. Lee et al.   SCIENCE

Helical Structures of ESCRT-III Are Disassembled by VPS4

(2008) S. Lata et al.   SCIENCE

Structure and Disassembly of Filaments Formed by the ESCRT-III Subunit Vps24

(2008) Sara Ghazi-Tabatabai et al.   STRUCTURE

DictyosteliumTom1 Participates to an Ancestral ESCRT-0 Complex

(2008) Cédric Blanc et al.   TRAFFIC

Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking

(2007) Camilla Raiborg et al.   EXPERIMENTAL CELL RESEARCH

3D Reconstruction of Mammalian Septin Filaments

(2007) Natalya Lukoyanova et al.   JOURNAL OF MOLECULAR BIOLOGY

Ist1 Regulates Vps4 Localization and Assembly

(2007) Christian Dimaano et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase

(2007) Bethan McDonald et al.   MOLECULAR BIOLOGY OF THE CELL