The biology and clinical implications of prostate cancer dormancy and metastasis

SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy

(2015) Anh Thu Bui et al.   CELL CYCLE

Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment

(2015) Donna M. Sosnoski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mitotic quiescence, but not unique “stemness,” marks the phenotype of bone metastasis-initiating cells in prostate cancer

(2015) Ning Wang et al.   FASEB JOURNAL

Significance of apoptotic and non-apoptotic disseminated tumor cells in the bone marrow of patients with clinically localized prostate cancer

(2015) Tilman Todenhöfer et al.   PROSTATE

The epigenetic/noncoding origin of tumor dormancy

(2015) Francesco Crea et al.   TRENDS IN MOLECULAR MEDICINE

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy

(2015) Nazanin Ruppender et al.   PLoS One

Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells

(2015) Takuya Nakamura et al.   Oncotarget

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

(2015) Lisly Chéry et al.   Oncotarget

TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition

(2015) Jin Koo Kim et al.   NEOPLASIA

Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes

(2014) M. Gu vi  et al.   CANCER RESEARCH

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone

(2014) P. D. Ottewell et al.   ENDOCRINE-RELATED CANCER

Prognostic relevance of disseminated tumour cells from the bone marrow of early stage breast cancer patients – Results from a large single-centre analysis

(2014) Andreas D. Hartkopf et al.   EUROPEAN JOURNAL OF CANCER

Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation

(2014) Hua Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial

(2013) Malgorzata Banys et al.   BMC CANCER

Single cell transcriptomic analysis of prostate cancer cells

(2013) Christopher J Welty et al.   BMC MOLECULAR BIOLOGY

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma

(2013) Tianjiao Lyu et al.   Epigenetics

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells

(2013) Lara H. El Touny et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

(2012) Hua Gao et al.   CELL

Staying alive

(2012) James R. Valcourt et al.   CELL CYCLE

Disseminated tumor cells and their prognostic significance in nonmetastatic prostate cancer patients

(2012) Wolfgang Lilleby et al.   INTERNATIONAL JOURNAL OF CANCER

Consensus Micro RNAs Governing the Switch of Dormant Tumors to the Fast-Growing Angiogenic Phenotype

(2012) Nava Almog et al.   PLoS One

Gap Junction-Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

(2011) P. K. Lim et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

(2011) Aya Kobayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of TROP2 (TACSTD2), an EpCAM-Like Molecule, as a Specific Marker for TGF-β1-Dependent Human Epidermal Langerhans Cells

(2011) Gregor Eisenwort et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Can We Stop Prostate Specific Antigen Testing 10 Years After Radical Prostatectomy?

(2011) Stacy Loeb et al.   JOURNAL OF UROLOGY

Notch Signaling Modulates Hypoxia-Induced Neuroendocrine Differentiation of Human Prostate Cancer Cells

(2011) G. Danza et al.   MOLECULAR CANCER RESEARCH

Asymmetric cancer cell division regulated by AKT

(2011) I. Dey-Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Which Patients With Undetectable PSA Levels 5 Years After Radical Prostatectomy Are Still at Risk of Recurrence?—Implications for a Risk-adapted Follow-up Strategy

(2010) Deborah A. Ahove et al.   UROLOGY

Disseminated Tumor Cells in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease Predicts Biochemical Recurrence

(2009) T. M. Morgan et al.   CLINICAL CANCER RESEARCH

Perioperative Activation of Disseminated Tumor Cells in Bone Marrow of Patients With Prostate Cancer

(2009) Dorothea Weckermann et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic Significance of Disseminated Tumor Cells in the Bone Marrow of Prostate Cancer Patients Treated With Neoadjuvant Hormone Treatment

(2008) Jens Köllermann et al.   JOURNAL OF CLINICAL ONCOLOGY