Article
Biochemistry & Molecular Biology
Lea P. Wilhelm, Juan Zapata-Munoz, Beatriz Villarejo-Zori, Stephanie Pellegrin, Catarina Martins Freire, Ashley M. Toye, Patricia Boya, Ian G. Ganley
Summary: This study reveals that both mitophagy and pexophagy are activated upon iron chelation in a BNIP3L/NIX-dependent manner. The NIX protein, known as a mitophagy receptor, is also found to localize to peroxisomes and drive pexophagy independently.
Review
Biochemistry & Molecular Biology
Mehdi Eshraghi, Aida Adlimoghaddam, Amir Mahmoodzadeh, Farzaneh Sharifzad, Hamed Yasavoli-Sharahi, Shahrokh Lorzadeh, Benedict C. Albensi, Saeid Ghavami
Summary: Alzheimer's disease is a debilitating neurological disorder with no current cure. Pathological features such as amyloid plaques and tau tangles are characteristic of AD, but targeting these has not shown desired efficacy in patients. Autophagy, inflammation, and microglia play significant roles in AD pathogenesis and may provide potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mingming Tong, Toshiro Saito, Peiyong Zhai, Shin-Ichi Oka, Wataru Mizushima, Michinari Nakamura, Shohei Ikeda, Akihiro Shirakabe, Junichi Sadoshima
Summary: The study found that during the chronic phase of obesity-associated cardiomyopathy, mitophagy is activated even after conventional autophagy is downregulated, serving as an essential mitochondrial quality control mechanism to protect the heart.
CIRCULATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lina Wang, Taotao Qiang, Longfang Ren, Fei Cheng, Wei Hu, Renyu Qu
Summary: Diabetic ulcers (DUs) have become a challenging disease due to unclear healing mechanisms, with the polarization state of macrophages and autophagy playing crucial roles in the delayed healing process.
Article
Biochemistry & Molecular Biology
Mariasole Perrone, Simone Patergnani, Tommaso Di Mambro, Laura Palumbo, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Summary: Maintenance of mitochondrial quality is crucial for cellular homeostasis. Mitophagy, the selective elimination of dysfunctional mitochondria, plays a significant role in various diseases, including carcinogenesis, neurodegenerative disorders, and cardiovascular pathologies. The relationship between calcium homeostasis and mitophagy is still a topic of debate.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Vaninad Romanello, Marco Sandri
Summary: Maintaining the function of mitochondria in skeletal muscle requires dynamic coordination of processes controlling mitochondrial network quality, which in turn affects muscle mass and performance. Loss of muscle mass increases the risk of disease onset and premature death, with exercise being the best approach to improve mitochondrial health and slow atrophy in various diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: This study reveals that carbon starvation induced by dark-incubation, natural senescence, and specific mitochondrial stresses are key triggers of mitophagy in plants.
Review
Cell Biology
Petra Teresak, Ana Lapao, Nemanja Subic, Patricia Boya, Zvulun Elazar, Anne Simonsen
Summary: Mitochondria are essential for cellular homeostasis, with mitophagy being a prominent mechanism to maintain a healthy mitochondrial pool. While the PINK1-PRKN pathway is well-studied for mitophagy, there are also alternative pathways involving different proteins and lipids. The significance of PRKN-independent mitophagy pathways in various physiological and pathophysiological processes highlights the need for further research into their regulation and interactions.
Article
Cell Biology
Sandra Franco-Iborra, Ainhoa Plaza-Zabala, Marta Montpeyo, David Sebastian, Miquel Vila, Marta Martinez-Vicente
Summary: The study found that HTT protein plays a crucial role in mitophagy, and the expansion of its polyQ tract affects this process, ultimately leading to the accumulation of damaged mitochondria and an increase in oxidative stress, leading to negative effects on mitochondrial dysfunction and neurodegeneration in Huntington disease.
Review
Cell Biology
Cheng-long Zhu, Ren-qi Yao, Lu-xi Li, Peng Li, Jian Xie, Jia-feng Wang, Xiao-ming Deng
Summary: Autophagy plays a vital role in maintaining cellular homeostasis by clearing damaged mitochondria to promote mitochondrial quality control and protect against organ dysfunction in sepsis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hongna Wang, Yongfeng Zheng, Jieru Huang, Jin Li
Summary: Mitophagy is a cellular process responsible for regulating mitochondrial quality and maintaining cellular homeostasis; however, viruses manipulate mitophagy to evade host immune attacks.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samil Jung, Davaajargal Myagmarjav, Taeyeon Jo, Soonduk Lee, Songyi Han, Nguyen Thi Ngoc Quynh, Nguyen Hai Anh, Son Hai Vu, Yeongseon Choi, Myeong-Sok Lee
Summary: Chemotherapy is widely used in cancer treatment, but the resistance of cancer cells to programmed cell death limits its effectiveness. This study focuses on the impact of cancer cell-specific mitophagy on resistance mechanisms. The findings suggest that TRIP-Br1 oncoprotein activates mitophagy, reducing the sensitivity of breast cancer cells to anticancer drugs and promoting cancer cell survival.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lauren H. Fairley, Imane Lejri, Amandine Grimm, Anne Eckert
Summary: Abnormal tau build-up is a hallmark of Alzheimer's disease and other neurodegenerative diseases. Mitochondrial dysfunction is associated with tau pathology. This study investigated the effects of spermidine, a neuroprotective polyamine, on mitochondrial function in a cellular model of tauopathy. The results showed that spermidine improved mitochondrial function and restored tau-induced impairments in mitophagy, suggesting that spermidine supplementation might be a potential therapeutic approach for tau-related mitochondrial impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Giampaolo Morciano, Simone Patergnani, Gaia Pedriali, Paolo Cimaglia, Elisa Mikus, Simone Calvi, Alberto Albertini, Carlotta Giorgi, Gianluca Campo, Roberto Ferrari, Paolo Pinton
Summary: This observational study aims to establish the trend of autophagy in CAVS patients, analyze the involvement of other determinants impacting mitochondrial quality control mechanisms, and explore potential pharmacological interventions. The results show deficiencies in mitochondrial respiration, ATP production, and alterations in biogenesis and mitophagy pathways in the calcified valves, suggesting a rapamycin-based therapeutic strategy to revert pathological phenotypes. Boosting autophagy and mitophagy could potentially counteract cell death and sustain cell functions in the long term.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nadezda Apostolova, Teresa Vezza, Jordi Muntane, Milagros Rocha, Victor M. Victor
Summary: Type 2 diabetes mellitus is closely linked to oxidative stress, mitochondrial dysfunction, and alterations in autophagy and mitophagy. Despite progress in understanding the molecular events associated with these processes, effective therapeutic strategies targeting these mechanisms are yet to be implemented.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
