Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases

Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma

(2013) R. G. Liao et al.   CANCER RESEARCH

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer

(2013) S. Fawdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation

(2013) Zhifeng Huang et al.   STRUCTURE

Cancer Somatic Mutations Disrupt Functions of the EphA3 Receptor Tyrosine Kinase through Multiple Mechanisms

(2012) Erika M. Lisabeth et al.   BIOCHEMISTRY

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

(2012) R M Linka et al.   LEUKEMIA

Evolution of the eukaryotic protein kinases as dynamic molecular switches

(2012) S. S. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor-Suppressing Kinase

(2011) J. Brognard et al.   CANCER RESEARCH

X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

(2011) Jodi Muckelbauer et al.   Chemical Biology & Drug Design

The role of LKB1 in lung cancer

(2011) Montse Sanchez-Cespedes   Familial Cancer

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors

(2011) Jean-Damien Charrier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor  2 Expression

(2011) Y.-H. Ahn et al.   MOLECULAR AND CELLULAR BIOLOGY

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors

(2011) Henning Stehr et al.   Molecular Cancer

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Functional Characterization of Human Cancer-Derived TRKB Mutations

(2011) Thomas R. Geiger et al.   PLoS One

The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

(2011) Anshuman Dixit et al.   PLoS One

Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases

(2011) Anshuman Dixit et al.   PLoS Computational Biology

LYN Is a Mediator of Epithelial-Mesenchymal Transition and a Target of Dasatinib in Breast Cancer

(2010) Y.-L. Choi et al.   CANCER RESEARCH

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Identification of an Allosteric Signaling Network within Tec Family Kinases

(2010) Raji E. Joseph et al.   JOURNAL OF MOLECULAR BIOLOGY

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

(2010) Jae Hyun Bae et al.   MOLECULES AND CELLS

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

(2010) Douglas J. Marcotte et al.   PROTEIN SCIENCE

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

(2010) Andreas Kuglstatter et al.   PROTEIN SCIENCE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif

(2009) Sonia Moretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Principal component analysis of native ensembles of biomolecular structures (PCA_NEST): insights into functional dynamics

(2009) Lee-Wei Yang et al.   BIOINFORMATICS

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

The phosphorylation specificity of B-RAFWT, B-RAFD594V, B-RAFV600E and B-RAFK601E kinases: An in silico study

(2009) Filip Fratev et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

(2009) Michael G. Gartside et al.   MOLECULAR CANCER RESEARCH

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

(2009) Mark W. Richards et al.   MOLECULAR CELL

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The structure of CDK4/cyclin D3 has implications for models of CDK activation

(2009) T. Takaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

(2009) N. Jura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

(2009) Anshuman Dixit et al.   PLoS Computational Biology

Prediction of Cancer Driver Mutations in Protein Kinases

(2008) A. Torkamani et al.   CANCER RESEARCH

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

(2008) Isaac Westwood et al.   JOURNAL OF MOLECULAR BIOLOGY

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

(2008) E. R. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congenital disease SNPs target lineage specific structural elements in protein kinases

(2008) Ali Torkamani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE