Article
Pharmacology & Pharmacy
Iqra Rahat, Md. Rizwanullah, Sadaf Jamal Gilani, May Nasser Bin-Jummah, Syed Sarim Imam, Chandra Kala, Mohammad Asif, Sultan Alshehri, Satish K. Sharma
Summary: Chitosan modified solid lipid nanoparticles were developed to enhance the oral bioavailability of thymoquinone, showing optimized nanoparticles with good in vitro and ex vivo performance, strong mucoadhesive properties, and controlled drug release. The results indicated significantly improved oral bioavailability compared to thymoquinone suspension.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Paurnima Talele, Anand Jadhav, Shivaji Tayade, Saugata Sahu, Kiran Kumar Sharma, Navinchandra Shimpi
Summary: Solid lipid nanoparticles (SLNs) loaded with hydroquinone (HQ) were successfully prepared using stearic acid and cationic/anionic emulsifiers. The physicochemical characterization of SLNs was performed, and the release behavior of HQ from SLNs was studied using an electrochemical method. The results showed that the concentration of emulsifier had a significant impact on the encapsulation and release of HQ.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Eliza Wolska, Marta Brach
Summary: The distribution of drug substances in solid lipid microparticles (SLM) was studied in order to distinguish the localization of drugs in the lipid matrix and on the surface of the microspheres. The traditional characterization methods based on entrapment efficiency (EE) and drug loading (DL) parameters were found to be insufficient. A new distribution test method was proposed to demonstrate the localization of drugs within the microspheres. This research provides new opportunities for the development and use of SLM as a carrier for prolonged drug release and other advantages.
Article
Biochemistry & Molecular Biology
Meihan Fang, Jialu Wang, Sheng Fang, Xiaobo Zuo
Summary: Gliadin-carboxymethyl chitosan composite nanoparticles (GC NPs) co-encapsulated with natamycin (Nata) and theaflavins (TFs) were added to carboxymethyl chitosan (CMCS) films as an antioxidant, antifungal, and structural enhancer. The stability of GC NPs dispersion was maintained by electrostatic repulsion. Coencapsulation of TFs improved the photostability of Nata and the antioxidant activity of the NPs dispersion. The addition of Nata/TFs-GC NPs improved the properties and activities of CMCS films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Hassan Raza, Shefaat Ullah Shah, Zakir Ali, Atif Ullah Khan, Irfa Basharat Rajput, Arshad Farid, Mohammed Al Mohaini, Abdulkhaliq J. J. Alsalman, Maitham A. A. Al Hawaj, Saima Mahmood, Abid Hussain, Kifayat Ullah Shah
Summary: In this study, FLU-ACT-coloaded nanostructured lipid carriers (NLCs) were successfully prepared to reduce side effects and enhance therapeutic efficacy. The optimized FLU-ACT-coloaded NLCs exhibited desired particle size, zeta potential, and encapsulation efficiency values. In vitro and ex vivo studies showed sustained release and minimal permeation of FLU and ACT from the FLU-ACT-coloaded NLC gel, compared to the FLU-ACT suspension and conventional gel.
Article
Spectroscopy
Paramita Saha, Murali Monohar Pandey
Summary: A new fluorescence-based method for estimating rotigotine in bulk and nanoformulations has been developed and validated. The method demonstrates good linearity and accuracy, and is specific and robust for use in pharmaceutical dosage forms.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He
Summary: In this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared to improve the sustained release and bioavailability of nonsteroidal anti-inflammatory drugs. The TA-SLN suspension showed improved sustained drug release in vitro and increased pharmacokinetic parameters in pigs compared with TA injection, indicating its potential as a promising new formulation.
Article
Pharmacology & Pharmacy
Antonella Obinu, Giovanni Pietro Burrai, Roberta Cavalli, Grazia Galleri, Rossana Migheli, Elisabetta Antuofermo, Giovanna Rassu, Elisabetta Gavini, Paolo Giunchedi
Summary: In this study, solid lipid nanoparticles (SLN) loaded with GEN were developed to improve its oral bioavailability by avoiding first-pass metabolism through intestinal lymphatic absorption. The SLN obtained by hot homogenization showed high stability and drug loading capacity.
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Article
Pharmacology & Pharmacy
Basalat Imran, Fakhar Ud Din, Zakir Ali, Anam Fatima, Muhammad Waseem Khan, Dong Wuk Kim, Maimoona Malik, Saba Sohail, Sibgha Batool, Muhammad Jawad, Kanwal Shabbir, Alam Zeb, Barkat Ali Khan
Summary: In this study, dexibuprofen solid lipid nanoparticles (DBPN-SLNs) were successfully prepared and optimized. The optimized formulation exhibited desirable morphological characteristics and stability, and significantly delayed the drug release, resulting in enhanced oral bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shabnam Dolatabadi, Maryam Karimi, Samira Nasirizadeh, Mahdi Hatamipour, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari
Summary: Curcuminoids-loaded solid lipid nanoparticles and nano structured lipid carriers demonstrated significant improvement in pharmacokinetic parameters, suggesting that these new formulations can enhance the bioavailability and absorption of curcuminoids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Taha Umair Wani, Altaf Hussain Pandith, Faheem A. Sheikh
Summary: The review highlights the importance of chitosan in biomedical applications, discussing its physicochemical properties and their impact on formulation development. The charge density and physicochemical properties of chitosan play a crucial role in determining the effectiveness of its applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhonghua Guo, Ping Qi, Donghong Pei, Xiuju Zhang
Summary: Osteoporosis is a common metabolic disorder and a major public health challenge. This study successfully developed Raloxifene HCl-loaded solid lipid nanoparticles decorated gel, which showed improved drug permeation and bioavailability, effectively treating osteoporosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emilli Antonio, Osmar dos Reis Antunes Junior, Rossana Gabriela Del Jesus Vasquez Marcano, Camila Diedrich, Juliane da Silva Santos, Christiane Schineider Machado, Najeh Maissar Khalil, Rubiana Mara Mainardes
Summary: Nanoparticles containing UA with chitosan modification were developed to improve oral bioavailability, showing potential application for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
M. Chalamaiah, T. Jyothirmayi, Prakash V. Diwan, B. Dinesh Kumar
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2015)
Article
Food Science & Technology
M. Chalamaiah, T. Jyothirmayi, Prakash V. Diwan, B. Dinesh Kumar
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2015)
Article
Nutrition & Dietetics
M. Chalamaiah, R. Hemalatha, T. Jyothirmayi, Prakash V. Diwan, K. Bhaskarachary, A. Vajreswari, R. Ramesh Kumar, B. Dinesh Kumar
Article
Food Science & Technology
Rahul P. Kshirsagar, Manikanta V. Kothamasu, Madhoosudan A. Patil, G. Bhanuprakash Reddy, B. Dinesh Kumar, Prakash V. Diwan
JOURNAL OF FUNCTIONAL FOODS
(2015)
Article
Chemistry, Medicinal
Rahul Motiram Kakalij, G. Tejaswini, Madhoosudan A. Patil, B. Dinesh Kumar, Prakash V. Diwan
DRUG DEVELOPMENT RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Rahul Motiram Kakalij, B. Dinesh Kumar, Prakash Vamanrao Diwan
INDIAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Plant Sciences
B. Hemanth Kumar, B. Dinesh Kumar, Prakash V. Diwan
PHARMACEUTICAL BIOLOGY
(2017)
Article
Pharmacology & Pharmacy
Abdul Bari Mohd, Krishna Sanka, Srikanth Bandi, Prakash V. Diwan, Nalini Shastri
Article
Chemistry, Applied
Abdul Bari, Naveen Chella, Krishna Sanka, Nalini R. Shastri, Prakash V. Diwan
JOURNAL OF MICROENCAPSULATION
(2015)
Article
Plant Sciences
Jayasingh Chellammal Hanish Singh, Rahul Motiram Kakalij, Rahul Padmakar Kshirsagar, Boyina Hemanth Kumar, Sai Santosh Babu Komakula, Prakash Vamanrao Diwan
PHARMACEUTICAL BIOLOGY
(2015)
Article
Pharmacology & Pharmacy
J. Chimakurthy, T. E. G. K. Murthy, P. V. Diwan
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Chemistry, Medicinal
Hemanth Kumar Boyina, Mahesh Kumar Jerald, Dinesh Kumar Bharatraj, Prakash Vamanrao Diwan
Article
Pharmacology & Pharmacy
Boyina Hemanth Kumar, Ravula Arun Reddy, Jerald Mahesh Kumar, B. Dinesh Kumar, Prakash V. Diwan
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2017)
Article
Chemistry, Applied
Rahul M. Kakalij, Kiran Gangarapu, B. Dinesh Kumar, Prakash V. Diwan
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2017)
Article
Food Science & Technology
M. Chalamaiah, T. Jyothirmayi, P. V. Diwan, Venu V. Babu, Purnendu S. Kumar, Dinesh B. Kumar
INTERNATIONAL FOOD RESEARCH JOURNAL
(2016)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)