Article
Biochemistry & Molecular Biology
Cintia A. Menendez, Alejandro R. Verde, Laureano M. Alarcon, Gustavo A. Appignanesi
Summary: Yerba mate tea, rich in phenolic antioxidants, particularly caffeoyl derivatives, interacts with lipid bilayers and exhibits antioxidant and anti-inflammatory activities.
BIOPHYSICAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Karthik Rathinam, Akshay Modi, Dietmar Schwahn, Yoram Oren, Roni Kasher
Summary: This study aims to reduce calcium phosphate scaling on reverse osmosis (RO) membranes during municipal wastewater desalination. By graft polymerization using hydrophilic methacrylate monomers, the modified membranes showed improved antiscaling performance, especially when grafted with neutral and mixed charge monomers.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Materials Science, Ceramics
Elisa Boanini, Massimo Gazzano, Katia Rubini, Paolo P. Mazzeo, Adriana Bigi
Summary: The study investigated the substitution of strontium for calcium in alpha-CaHPO4 and beta-SrHPO4, as well as the influence of synthesis methods on the structures. The results showed that strontium substitution in alpha-CaHPO4 can reach up to 100%, while in beta-SrHPO4 it is limited to about 20%. Additionally, powder X-ray analysis revealed that beta-SrHPO4 crystallizes with a monoclinic cell in the space group P21/c.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Meng Sun, Dongqi Liu, Guogeng Yin, Wenhui Li, Youhua Zhou, Wangting Lu, Yijie Chen, Hongjuan Zhang, Feng Wei
Summary: The effects of magnesium ions on the conformational changes of the D54-DMPE monolayer were investigated using SFG-VS and surface pressure-area isotherm measurements. It was observed that the tilt angles of the methyl in the tail groups decreased, while the tilt angles of the phosphate and methylene in the head groups increased during compression. Additionally, as the MgCl2 concentration increased, the tilt angles of the phosphate and methylene significantly increased.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Review
Food Science & Technology
Ana-Isabel Mulet-Cabero, Peter J. Wilde
Summary: This review explores the possible mechanisms of calcium in reducing cholesterol, including its interaction with fatty acids and bile acids, and provides clinical evidence. The interaction of calcium with blood lipid metabolism may depend on its multiple roles in lipid digestion in the small intestine and its influence on the solubilization and absorption of cholesterol through its interaction with fatty acids and bile.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Tamas Kovacs, Tamas Sohajda, Lajos Szente, Peter Nagy, Gyorgy Panyi, Zoltan Varga, Florina Zakany
Summary: Cyclodextrins are able to form water-soluble complexes and have effects on cellular functions and drug solubility. Studies suggest that cyclodextrins may have direct effects on K-V channels, potentially leading to additional effects during therapeutic applications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vimala Bondada, Jozsef Gal, Charles Mashburn, David W. Rodgers, Katherine E. Larochelle, Dorothy E. Croall, James W. Geddes
Summary: CAPN5 is a ubiquitous enzyme highly expressed in the central nervous system and associated with eye development and disease. The study revealed that CAPN5 undergoes calcium-activated autoproteolytic processing, and membrane association enhances CAPN5 autolysis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Cell Biology
Carlos Enrich, Albert Lu, Francesc Tebar, Carles Rentero, Thomas Grewal
Summary: Membrane contact sites (MCS) are specialized areas connecting different organelles and allowing lipid and ion transfer, challenging the traditional concept of intercellular communication via vesicular trafficking. MCS serve as metabolic platforms crucial for cellular homeostasis. Recent studies have identified proteins involved in MCS regulation, providing insights into human diseases and potential treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bilge Ercan, Tomoki Naito, Dylan Hong Zheng Koh, Dennis Dharmawan, Yasunori Saheki
Summary: The GRAM domain of GRAMD1b plays a crucial role in detecting cholesterol and anionic lipids, with mutations potentially leading to intellectual disabilities in humans. Cell utilize the GRAM domain to regulate the rate of cholesterol transport and membrane tethering.
Article
Biochemistry & Molecular Biology
Laura Lemel, Katarzyna Niescierowicz, M. Dolores Garcia-Fernandez, Leonardo Darre, Thierry Durroux, Marta Busnelli, Mylene Pezet, Fabrice Rebeille, Juliette Jouhet, Bernard Mouillac, Carmen Domene, Bice Chini, Vadim Cherezov, Christophe J. Moreau
Summary: The study revealed a stable binding of cholesterol molecules to OXTR in the presence of orthosteric ligands, leading to a positive cross-regulation between cholesterol and orthosteric ligands, which preserves the activity of the receptor in cholesterol-depleted membranes.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi
Summary: PKC zeta and PKC iota/lambda form the atypical protein kinase C subgroup, characterized by their regulation distinct from conventional PKCs. Both PKC zeta and PKC iota interact with phosphatidic acid and phosphatidylserine, while PKC iota uniquely binds to phosphatidylinositol-monophosphates. Additionally, phosphatidylinositol 4-phosphate specifically activates PKC iota, indicating a specific regulation of PKC iota by certain membrane lipids.
Article
Food Science & Technology
Yunna Wang, Xin Cui, Yang Li, Shiran Wang, Guosen Yan, Liebing Zhang, Yan Li
Summary: This study investigated the effects of different pH levels and ionic strength in calcium on the stability and aeration characteristics of dairy emulsions. The results showed that increasing the pH value from 6.5 to 7.0 enhanced the stability and aeration characteristics, with the optimal range being pH 6.8 to 7.0 and a concentration of free calcium ions (Ca2+) of 2.94 to 3.22 mM. However, when the addition of CaCl2 increased to 2.00 mM (free Ca2+ strength > 4.11 mM) at pH 6.8 and 7.0, the stability and aeration characteristics significantly decreased, leading to detrimental effects on the quality of the dairy emulsions.
Article
Biochemistry & Molecular Biology
Yanxing Yang, Sharareh Jalali, Bradley L. Nilsson, Cristiano L. Dias
Summary: The study found that electrostatic and hydrophobic interactions play important roles in the peptide-bilayer binding process. Peptides are strongly attracted to anionic lipid bilayers due to electrostatic interactions between positive residues and negative phosphate moieties. However, the presence of calcium ions significantly reduces the binding of peptides to the bilayer.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Federica Scollo, Huseyin Evci, Mariana Amaro, Piotr Jurkiewicz, Jan Sykora, Martin Hof
Summary: The structure organization of biomolecules and bioassemblies is greatly influenced by their interactions with water. The time-dependent fluorescence shift (TDFS) method is a valuable tool for studying hydration in biological systems, especially for understanding the hydration and mobility of hydrated phospholipid segments in phospholipid bilayers. The TDFS outputs provide insights into the hydration phenomena and can be used to study the effects of ions and oxidized phospholipids on bilayer organization.
FRONTIERS IN CHEMISTRY
(2021)
Article
Infectious Diseases
Ayse Oen, Djenana Vejzovic, James Jennings, Lena Parigger, Robert A. Cordfunke, Jan Wouter Drijfhout, Karl Lohner, Nermina Malanovic
Summary: OP-145 and SAAP-148, derived from LL-37, show effective killing against both Gram-positive and Gram-negative bacteria. However, their impact on Escherichia coli does not align with membrane permeabilization. In this study, we used a combination of techniques to investigate their mode of action and found distinct binding patterns and permeabilization effects depending on the LPS phenotypes. Our findings suggest that depolarization of the cytoplasmic membrane and disruption of lipid packing are crucial for their bactericidal activity.
Article
Chemistry, Analytical
Shivender Singh Saini, M. Florencia Martini
Summary: A green hybrid method involving pipette tip micro solid phase extraction (PT-mu SPE) and supported liquid extraction (SLE) was developed for sensitive determination of bisphenol A (BPA) in water and thermal paper samples. Three different sorbents were utilized, with chitosan demonstrating the best performance in terms of detection limit, recovery, precision, and repeatability values among chitin, chitosan, and cellulose acetate. Computational simulations provided insights into possible sorbent-analyte interactions, and the method showed potential for expansion to other emerging contaminants in various aqueous matrices.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Maria Sol Shmidt, Maria Florencia Martini, Guido A. Oppezzo, Maria Mercedes Blanco, Albertina G. Moglioni
Summary: This study details the reaction of dimethyl acetylenedicarboxylate with aniline derivatives, showing the diasteromeric enamines obtained were characterized using H-1 and C-13 NMR spectra and computational methods. The heterocyclization reactions of the isolated diasteromeric enamines resulted in different products depending on reaction conditions and substrate characteristics, leading to the discovery of new routes for synthesizing specific derivatives.
Article
Food Science & Technology
Pablo E. Antezana, Sofia Municoy, Martin G. Bellino, M. Florencia Martini, Martin F. Desimone
Summary: The development of a water-soluble peptide formulation L-GraS, where GraS is incorporated into the lipid bilayer of liposomes, showed bactericidal activity and enhanced biocompatibility compared to the free peptide. Molecular dynamics simulations confirmed the effective incorporation of GraS in the liposomes.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2021)
Article
Immunology
Andrea Ziblat, Ximena Lucia Raffo Iraolagoitia, Sol Yanel Nunez, Nicolas Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raul German Spallanzani, Agustin Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Ines Domaica, Norberto Walter Zwirner
Summary: The study found that NK cells from ccRCC patients exhibit different activation characteristics compared to those from healthy donors, with NK cells in the tumor microenvironment showing higher activation markers and a more inhibitory phenotype. Overexpression of specific molecules is associated with an NK cell infiltration signature, potentially serving as new biomarkers for ccRCC patients and providing novel targets for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jessica M. Sierra, Florencia Secchiari, Sol Y. Nunez, Ximena L. Raffo Iraolagoitia, Andrea Ziblat, Adrian D. Friedrich, Maria V. Regge, M. Cecilia Santilli, Nicolas I. Torres, Mariana Gantov, Aldana Trotta, Carlos Ameri, Gonzalo Vitagliano, Hernando Rios Pita, Luis Rico, Agustin Rovegno, Nicolas Richards, Carolina I. Domaica, Norberto W. Zwirner, Mercedes B. Fuertes
Summary: NK cells in clear cell renal cell carcinoma patients display altered phenotype and impaired effector functions, with a high frequency of tumor-infiltrating PD-L1(+) NK cells suggesting immunoregulatory functions. In vitro studies show that PD-L1(hi) NK cells exhibit an activated phenotype and enhanced effector functions, while also inhibiting CD8(+) T cell proliferation in a PD-L1-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriel Jasinski, Emir Salas-Sarduy, Daniel Vega, Lucas Fabian, Maria Florencia Martini, Albertina G. Moglioni
Summary: This study evaluated the effects of eleven thiosemicarbazones on cruzipain and investigated their interactions with the enzyme's active site and inhibition mechanism through computational methods. The results suggest that thiosemicarbazones exhibit inhibitory activity against cruzipain.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Jack Leslie, John B. G. Mackey, Thomas Jamieson, Erik Ramon-Gil, Thomas M. Drake, Frederic Fercoq, William Clark, Kathryn Gilroy, Ann Hedley, Colin Nixon, Saimir Luli, Maja Laszczewska, Roser Pinyol, Roger Esteban-Fabro, Catherine E. Willoughby, Philipp K. Haber, Carmen Andreu-Oller, Mohammad Rahbari, Chaofan Fan, Dominik Pfister, Shreya Raman, Niall Wilson, Miryam Muller, Amy Collins, Daniel Geh, Andrew Fuller, David McDonald, Gillian Hulme, Andrew Filby, Xabier Cortes-Lavaud, Noha-Ehssan Mohamed, Catriona A. Ford, Ximena L. Raffo Iraolagoitia, Amanda J. McFarlane, Misti McCain, Rachel A. Ridgway, Edward W. Roberts, Simon T. Barry, Gerard J. Graham, Mathias Heikenwalder, Helen L. Reeves, Josep M. Llovet, Leo M. Carlin, Thomas G. Bird, Owen J. Sansom, Derek A. Mann
Summary: This study found that targeting neutrophils using a CXCR2 small molecule inhibitor can enhance the sensitivity of non-alcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) to immune checkpoint inhibition therapy (ICI). The combination therapy can reprogram the tumor immune microenvironment, increase the number of anti-tumor immune cells, and improve treatment outcomes.
Article
Oncology
Florencia Secchiari, Sol Yanel Nunez, Jessica Mariel Sierra, Andrea Ziblat, Maria Victoria Regge, Ximena Lucia Raffo Iraolagoitia, Agustin Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolas Richards, Hernando Rios Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolas Bonanno, Leandro Blas, Aldana Trotta, Adrian David Friedrich, Mercedes Beatriz Fuertes, Carolina Ines Domaica, Norberto Walter Zwirner
Summary: NKG2D is an important activating receptor of natural killer (NK) cells that recognizes multiple ligands, including MICA. This study found that MICA is overexpressed in renal cell carcinoma (RCC) and is associated with decreased overall survival in RCC patients. Both tumor cells and tumor-infiltrating leukocytes showed increased MICA expression, while peripheral blood NK cells exhibited downregulated NKG2D. Furthermore, these NKG2D-expressing tumor-infiltrating NK cells displayed functional impairment and altered metabolic fitness.
Article
Biophysics
Laura C. Laurella, Albertina G. Moglioni, Florencia Martini
Summary: The discovery of the endocannabinoid system (ECS) is relatively recent, with only 30 years of history. Despite extensive research on its components, functions, and metabolism, there are still unanswered questions and controversies regarding the neurotransmitters of ECS. This study investigates the molecular behavior of endocannabinoid and phytocannabinoid compounds in eukaryotic model membranes, specifically focusing on their mobility and interaction with lipid bilayers. The results suggest that these bioactive molecules exhibit different behaviors in the outer and inner model membranes, providing important insights into the understanding of the ECS and the cannabinoids found in cannabis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Shivender Singh Saini, Guillermo J. Copello, M. Florencia Martini
Summary: In this study, an ultrasound-assisted solid phase extraction method utilizing a rotating cigarette filter was developed for the preconcentration and determination of trace amounts of bisphenol A in source and drinking water. High-performance liquid chromatography coupled with UV detector was used for qualitative and quantitative measurements. The sorbent-analyte interactions were investigated computationally and experimentally, and various extraction parameters were optimized. The proposed method exhibited good linearity, low detection limit, high precision, and recovery, providing a cost-effective, simple, fast, and sensitive analytical approach for the determination of bisphenol A in water samples.
ANALYTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lucia Cane, Fanny Guzman, Galo Balatti, Maria Antonieta Daza Millone, Melisa Pucci Molineris, Sabina Mate, M. Florencia Martini, Vanesa Herlax
Summary: This study revealed that the pore-forming protein Alphahemolysin of Escherichia coli (HlyA) interacts with cholesterol to facilitate its insertion into membranes. Two peptides derived from different cholesterol-binding sites were found to interact preferentially with cholesterol-containing membranes, with one of them (PEP 2) inhibiting the hemolytic activity of HlyA.
Article
Chemistry, Medicinal
Gabriel Jasinski, Emir Salas-Sarduy, Daniel Vega, Lucas Fabian, M. Florencia Martini, Albertina G. Moglioni
Summary: Based on literature data, a QSAR model was developed to predict the activity of TSCs. New TSCs were designed and tested against CZP, resulting in highly potent inhibitors. Molecular docking and QM/QM ONIOM refinement studies confirmed the expected binding mode for the active TSCs. Kinetic experiments showed that the new TSCs act through the formation of a reversible covalent adduct. These findings highlight the effectiveness of QSAR and molecular modeling techniques in the design of potent CZ/CZP inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
G. E. Balatti, M. F. Martini, M. Pickholz
Summary: This study investigated the interaction between Aurein 1.2 peptide and model bacterial membranes with varying glycolipid content using molecular dynamics simulations. The presence of glycolipids was found to affect the ability of Aurein 1.2 to stabilize pore structures, suggesting a mechanism of bacterial resistance to antimicrobial peptides related to the glycolipid content.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Jimena Borgo, Orlando G. Elso, Jessica Gomez, Mauro Coll, Cesar A. N. Catalan, Juan Mucci, Guzman Alvarez, Lia M. Randall, Patricia Barrera, Emilio L. Malchiodi, Augusto E. Bivona, Maria Florencia Martini, Valeria P. Suelsen
Summary: Stevia species, particularly S. satureiifolia var. satureiifolia and S. alpina, are rich in terpenoid compounds with antiprotozoal activity. Two sesquiterpene lactones, santhemoidin C and 2-oxo-8-deoxyligustrin, were isolated and evaluated for their trypanocidal activity against Trypanosoma cruzi. Santhemoidin C showed promising inhibitory activity against the parasite's different stages and the Tc80 protein, making it a potential candidate for the development of trypanocidal drugs.
Article
Toxicology
Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L. Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M. Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J. Murphy
Summary: Asbestos-driven inflammation contributes to the severity of malignant pleural mesothelioma beyond genetic mutations. The injection of asbestos in genetically modified mice significantly accelerated tumor development and increased macrophage infiltration. However, suppression of macrophages in established tumors did not improve survival or enhance response to chemotherapy.
FRONTIERS IN TOXICOLOGY
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
