Article
Agricultural Engineering
Huazhong Ma, Jianglin Zhao, Ying Liu, Liang Liu, Juan Yu, Yimin Fan
Summary: An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Polymer Science
Fabio Pizzetti, Anna Maspes, Arianna Rossetti, Filippo Rossi
Summary: Hydrogels have shown promise in various medical applications, such as controlled drug delivery systems and tissue engineering scaffolds. Careful material design is crucial for achieving desired properties. By modifying the 3D network of agarose-carbomer hydrogels with hyaluronic acid chains as degradable cross-links, the degradation kinetics of the hydrogels can be tuned to improve tissue regrowth.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Engineering, Chemical
Nandita Srivastava, Anirban Roy Choudhury
Summary: Hydrogels are soft materials that undergo cross-linking to form a hydrophilic three-dimensional network. Stimuli-responsive hydrogels have the ability to undergo reversible transitions in response to external cues. Recently, polysaccharide-based hydrogels with stimuli-responsive properties have shown promising applications in biotechnology due to their biodegrability, biocompatibility, and functional properties.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Polymer Science
Samia Afrin, Shahruzzaman, Papia Haque, Sazedul Islam, Shafiul Hossain, Taslim Ur Rashid, Tanvir Ahmed, Makoto Takafuji, Mohammed Mizanur Rahman
Summary: A Semi Interpenetrating Polymer Network hydrogel loaded with gentamicin was prepared for studying its wound healing activity. The hydrogel, synthesized by combining cellulose nanocrystal and synthetic polymers, exhibited excellent biocompatibility and antimicrobial properties. In vitro and in vivo tests confirmed its ability to promote rapid wound healing without scar formation.
Article
Pharmacology & Pharmacy
Tamara Athamneh, Adil Amin, Edit Benke, Rita Ambrus, Pavel Gurikov, Irina Smirnova, Claudia S. Leopold
Summary: The study utilized aerogel technology to prepare pulmonary drug carriers with high porosity, low density, and large surface area suitable for pulmonary drug delivery, demonstrating a non-Fickian drug release mechanism.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Christopher C. Parkins, Joseph H. McAbee, Lisa Ruff, Astrid Wendler, Richard Mair, Richard J. Gilbertson, Colin Watts, Oren A. Scherman
Summary: The study utilized a new class of drug delivery reservoirs to improve drug bioavailability for glioblastoma tumors, measured the mechanical properties of human and mouse tissues, and found that treatment with drug-loaded hydrogels significantly increased survival impact. Additionally, a correlation between tumor type formed and initial survival was observed due to the heterogeneity of GB tumors.
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Xiaodong Jing, Yanzhen Sun, Xiaoli Ma, Hao Hu
Summary: Marine polysaccharides, as green and renewable resources, possess excellent biological properties and can be used to prepare various types of dressings, showing promising effects in wound repair.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Engineering, Biomedical
Yan Hu, Bangrui Yu, Yuanbo Jia, Meng Lei, Zhijie Li, Hao Liu, Haishui Huang, Feng Xu, Jing Li, Zhao Wei
Summary: A bioadhesive and injectable ECM-mimicking hydrogel dressing with antibacterial capacity has been developed for burn injury therapy. The HG/Doxy hydrogel dressing exhibits biocompatibility and antibacterial activity against both Gram-positive and Gram-negative bacteria. In a rat model of burn wound, the HG/Doxy hydrogel dressing significantly accelerates wound closure and promotes skin structure regeneration, demonstrating its potential for clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Cavallaro, Lorenzo Lisuzzo, Giuseppe Lazzara, Stefana Milioto
Summary: The design of hydrogels for controlled release of active species is challenging yet attractive. In this study, hybrid hydrogels composed of halloysite nanotubes and alginate were prepared, featuring a unique wire-like shape. The interaction between the morphology and dimensions of the hydrogel wires was found to significantly affect the release of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Applied
Tania Moniz, Sofia A. Costa Lima, Salette Reis
Summary: Transdermal drug delivery is considered a promising route for administration of pharmaceutical and cosmetic active ingredients, with the use of microneedles as a method to enhance drug permeation. Polymer microneedles made from sustainable marine polysaccharides like chitosan have shown great potential for transdermal drug delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Touba Khaliq, Muhammad Sohail, Muhammad Usman Minhas, Arshad Mahmood, Abubakar Munir, Aya Hamid Mohammad Qalawlus, Nazish Jabeen, Mubeen Kousar, Zobia Anwar
Summary: The study aims to develop a new multifunctional biopolymer-based hydrogel membrane dressing that can release cefotaxime sodium at the wound site. Sodium alginate enhances collagen production in the skin, while hyaluronic acid plays a significant role in the wound healing cascade. These biopolymers are essential ingredients for the fabrication of hydrogel membranes. The developed membranes showed suitable characteristics for wound healing of diabetic wounds, with rapid re-epithelization and decreased inflammation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Applied
Xiaodan Zhang, Danyi Wei, Yang Xu, Qiang Zhu
Summary: Hyaluronic acid, a naturally-occurring polysaccharide in ophthalmic tissues, has a wide range of applications in the treatment of ocular diseases. Recent advances in HA-based drug delivery systems have shown the importance of rational selection of molecular weight and amount of HA for diverse delivery systems.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Regina Vildanova, Alexander Lobov, Leonid Spirikhin, Sergey Kolesov
Summary: This study developed biodegradable polysaccharide hydrogel matrices that can enhance the therapeutic effects of cytostatic drugs by prolonging drug action, reducing toxicity, and providing additional biological activity. The interaction between N-succinyl chitosan and hyaluronic acid dialdehyde resulted in the formation of azomethine bonds. The rheological properties of the hydrogels and the molecular weight of N-succinyl chitosan influenced the drug release behavior. The formulation with the highest molecular weight of N-succinyl chitosan and mitomycin C showed the most promising results for medical application.
Article
Chemistry, Applied
Carla Giometti Franca, Tanya Plaza, Nelson Naveas, Maria Helena Andrade Santana, Miguel Manso-Silvan, Gonzalo Recio, Jacobo Hernandez-Montelongo
Summary: The study demonstrated that nPSi microparticles can effectively enhance the mechanical stability and drug release control of oxi-HA/ADH hydrogel, while also showing an improvement in the efficient release kinetics control for the model drug RB.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Rosario Pignatello, Pietro Matricardi
Article
Physics, Condensed Matter
S. Franco, E. Buratti, B. Ruzicka, V Nigro, N. Zoratto, P. Matricardi, E. Zaccarelli, R. Angelini
Summary: Interpenetrated polymer network microgels composed of poly(N-isopropylacrylamide) and polyacrylic acid (PAAc) were investigated through rheological measurements, revealing that PAAc content and crosslinking degree can significantly influence particle dimensions, mass, softness, volume fraction, and system viscosity.Particles with higher PAAc content and crosslinker exhibit larger volume fractions and greater values of a parameter k, resulting in steeper increases in viscosity compared to softer particles. The viscosity of microgels exhibits different dependencies on packing fraction based on PAAc concentration, with a quantitative agreement found with the structural relaxation time measured through dynamic light scattering.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2021)
Article
Biochemistry & Molecular Biology
Patrizia N. Hanieh, Jacopo Forte, Chiara Di Meo, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantu, Federica Rinaldi, Carlotta Marianecci, Maria Carafa
Summary: Hyaluronic acid (HA) is a widely used biopolymer in drug delivery systems due to its biocompatibility and targeting properties. HA can be chemically modified to enhance its application, such as coating nanovesicles with cholesterol derivatives for improved targeting. Coated nanocarriers show promising features for active targeting strategies.
Article
Polymer Science
Tommasina Coviello, Franco Alhaique, Chiara Di Meo, Pietro Matricardi, Elita Montanari, Nicole Zoratto, Mario Grassi, Michela Abrami
Summary: This study investigates the effects of the addition of borax on a mixed system of Scleroglucan and guar gum. It reveals synergistic effects in terms of critical time, mesh size, and crosslinking density. The study also finds that the flexible chains of guar gum contribute to the self-healing properties of the mixed gel system.
EXPRESS POLYMER LETTERS
(2022)
Article
Pharmacology & Pharmacy
Nicole Zoratto, Laura Forcina, Roberto Matassa, Luciana Mosca, Giuseppe Familiari, Antonio Musaro, Maurizio Mattei, Tommasina Coviello, Chiara Di Meo, Pietro Matricardi
Summary: The study shows the activity of hyaluronan-cholesterol nanogels as ocular permeation enhancers, enhancing the penetration of drugs in the eye and improving bioavailability, particularly for treating anterior and posterior eye segment diseases.
Article
Instruments & Instrumentation
Sabina Di Matteo, Chiara Di Meo, Guido Carpino, Nicole Zoratto, Vincenzo Cardinale, Lorenzo Nevi, Diletta Overi, Daniele Costantini, Claudio Pinto, Elita Montanari, Marco Marzioni, Luca Maroni, Antonio Benedetti, Marco Viola, Tommasina Coviello, Pietro Matricardi, Eugenio Gaudio, Domenico Alvaro
Summary: The intrahepatic biliary epithelium plays a significant role in excreting bicarbonate in bile. Recent studies have shown that budesonide enhances the efficacy of ursodeoxycholic acid in primary biliary cholangitis patients. This study investigates the effects of dexamethasone-loaded nanohydrogels (NHs) on transport processes in the biliary epithelium and liver injury induced by experimental cholestasis. The results suggest that NHs/dex formulation could be a promising candidate for further investigation in preclinical models of cholangiopathies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rosa Calderon-Jacinto, Pietro Matricardi, Virginie Gueguen, Graciela Pavon-Djavid, Emmanuel Pauthe, Violeta Rodriguez-Ruiz
Summary: This study focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol(R)-based hydrogel system for the topical delivery of curcumin to the skin. The results demonstrate that CUR-NLCs have high curcumin antioxidant activity and moderate anti-migration/proliferation effect. The dual CUR-NLC/hydrogel system shows potential application in adjuvant treatment for topical dermatological applications.
Article
Polymer Science
Marco Viola, Claudia Migliorini, Pietro Matricardi, Chiara Di Meo
Summary: Polyacrylic acid (PAA) is a synthetic homopolymer with rheological and mucoadhesive properties, making it important in pharmaceutical and cosmetic fields. It can be modified to create new derivatives with enhanced and tuned properties, such as block copolymers, cross-linked gels, and amphiphilic polymers. This study reports the preparation and characterization of a novel water-soluble polymer with amphiphilic properties, achieved through functionalization with cholesterol moieties. The polymer also shows potential in improving the solubility of poorly water-soluble drug molecules.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Pauline Marie Chichiricco, Pietro Matricardi, Bruno Colaco, Pedro Gomes, Christine Jerome, Julie Lesoeur, Joelle Veziers, Gildas Rethore, Pierre Weiss, Xavier Struillou, Catherine Le Visage
Summary: In recent years, multicomponent hydrogels, such as interpenetrating polymer networks (IPNs), have gained attention as innovative biomaterials due to their synergistic combination of properties. This study explores an innovative non-animal IPN hydrogel that combines self-setting silanized hydroxypropyl methylcellulose (Si-HPMC) with photochemically cross-linkable dextran methacrylate (DexMA) as a potential alternative to porcine collagen membranes in guided bone regeneration. Results showed that the IPN hydrogel exhibited improved physicochemical properties and instant gel formation under visible light. The cytocompatibility and mineral deposition in critical-size defects were comparable to the positive control, demonstrating the potential of this IPN hydrogel as an alternative to animal-derived collagen membranes.
BIOENGINEERING-BASEL
(2023)
Review
Pharmacology & Pharmacy
Ju Wang, Marco Viola, Claudia Migliorini, Luca Paoletti, Silvia Arpicco, Chiara Di Meo, Pietro Matricardi
Summary: Nanocarriers, particularly polysaccharide-based nanogels, offer great potential as drug delivery systems to overcome biological barriers and enhance treatment efficacy.
Article
Engineering, Biomedical
Marco Viola, Claudia Migliorini, Fabio Ziarelli, Stephane Viel, Claudia Cencetti, Daniel Di Risola, Luciana Mosca, Laura Masuelli, Pietro Matricardi, Chiara Di Meo
Summary: The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, has been extensively characterized and investigated, showing promising potential as an innovative excipient. It can enhance drug solubility, viscosity, and emulsifying properties, and forms stable hydrogel complexes with chitosan.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
