Controlled delivery of aspirin from nanocellulose-sodium alginate interpenetrating network hydrogels

An interpenetrating network (IPN) hydrogel was developed by the miscibility between nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. Double crosslinking played a key role during the construction of the IPN hydrogel network. The nanofibers significantly prolonged the aspirin release time to similar to 60 h, which benefits from the rich and regular network structure of the hydrogel. Carboxyl groups contribute to the variation in release capacity in different pH environments. The strategy proposed in this study would guide the preparation of purely physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility and their application in the drug delivery field. This study aimed to explore the double crosslinking process for prolonged aspirin release capacity between nanocellulose and sodium alginate. The obtained results suggested that a pH-sensitive nanocellulose-sodium alginate IPN hydrogel would be an ideal aspirin carrier for long-term release.

Automated summary

An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.